Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments

Autores
Pardini, Francisco Martín; Faccia, Paula Andrea; Amalvy, Javier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH-responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Amalvy, Javier. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina. Universidad Tecnológica Nacional; Argentina
Materia
Drug Delivery Systems
Films
Poly(N,N-Diethylaminoethyl Methacrylate)
Polymeric Hybrid Materials
Polyurethanes
Stimuli-Sensitive Polymers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/49513
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/49513
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developmentsPardini, Francisco MartínFaccia, Paula AndreaAmalvy, JavierDrug Delivery SystemsFilmsPoly(N,N-Diethylaminoethyl Methacrylate)Polymeric Hybrid MaterialsPolyurethanesStimuli-Sensitive Polymershttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH-responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Amalvy, Javier. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina. Universidad Tecnológica Nacional; ArgentinaEditions Sante2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/49513Pardini, Francisco Martín; Faccia, Paula Andrea; Amalvy, Javier; Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments; Editions Sante; Journal of Drug Delivery Science and Technology; 30; 12-2015; 199-2081773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2015.10.016info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1773224715300496info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:06:39Zoai:ri.conicet.gov.ar:11336/49513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:06:39.561CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
spellingShingle Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
Pardini, Francisco Martín
Drug Delivery Systems
Films
Poly(N,N-Diethylaminoethyl Methacrylate)
Polymeric Hybrid Materials
Polyurethanes
Stimuli-Sensitive Polymers
title_short Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_full Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_fullStr Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_full_unstemmed Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
title_sort Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
dc.creator.none.fl_str_mv Pardini, Francisco Martín
Faccia, Paula Andrea
Amalvy, Javier
author Pardini, Francisco Martín
author_facet Pardini, Francisco Martín
Faccia, Paula Andrea
Amalvy, Javier
author_role author
author2 Faccia, Paula Andrea
Amalvy, Javier
author2_role author
author
dc.subject.none.fl_str_mv Drug Delivery Systems
Films
Poly(N,N-Diethylaminoethyl Methacrylate)
Polymeric Hybrid Materials
Polyurethanes
Stimuli-Sensitive Polymers
topic Drug Delivery Systems
Films
Poly(N,N-Diethylaminoethyl Methacrylate)
Polymeric Hybrid Materials
Polyurethanes
Stimuli-Sensitive Polymers
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH-responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Amalvy, Javier. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina. Universidad Tecnológica Nacional; Argentina
description Smart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH-responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/49513
Pardini, Francisco Martín; Faccia, Paula Andrea; Amalvy, Javier; Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments; Editions Sante; Journal of Drug Delivery Science and Technology; 30; 12-2015; 199-208
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/49513
identifier_str_mv Pardini, Francisco Martín; Faccia, Paula Andrea; Amalvy, Javier; Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments; Editions Sante; Journal of Drug Delivery Science and Technology; 30; 12-2015; 199-208
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2015.10.016
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1773224715300496
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editions Sante
publisher.none.fl_str_mv Editions Sante
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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