Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic...

Autores
Faccia, Paula; Pardini, Francisco; Amalvy, Javier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH- sensitive drug delivery system for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by FTIR spectroscopy and SEM. The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
Fil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina
Fil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; Argentina
Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina
Peer Reviewed
Materia
Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/3408
Acceder
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network_name_str Repositorio Institucional Abierto (UTN)
spelling Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugsFaccia, PaulaPardini, FranciscoAmalvy, JavierSmart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systemsSmart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH- sensitive drug delivery system for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by FTIR spectroscopy and SEM. The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.Fil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; ArgentinaFil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; ArgentinaFil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); ArgentinaPeer Reviewed2019-02-01T14:46:27Z2019-02-01T14:46:27Z2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfeXPRESS Polymer Lettershttp://hdl.handle.net/20.500.12272/340810.3144/expresspolymlett.2015.52enginfo:eu-repo/semantics/openAccessAtribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2025-10-16T10:10:40Zoai:ria.utn.edu.ar:20.500.12272/3408instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-10-16 10:10:40.921Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
spellingShingle Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
Faccia, Paula
Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
title_short Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_full Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_fullStr Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_full_unstemmed Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_sort Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
dc.creator.none.fl_str_mv Faccia, Paula
Pardini, Francisco
Amalvy, Javier
author Faccia, Paula
author_facet Faccia, Paula
Pardini, Francisco
Amalvy, Javier
author_role author
author2 Pardini, Francisco
Amalvy, Javier
author2_role author
author
dc.subject.none.fl_str_mv Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
topic Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
dc.description.none.fl_txt_mv Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH- sensitive drug delivery system for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by FTIR spectroscopy and SEM. The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
Fil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina
Fil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; Argentina
Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina
Peer Reviewed
description Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH- sensitive drug delivery system for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by FTIR spectroscopy and SEM. The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
publishDate 2015
dc.date.none.fl_str_mv 2015
2019-02-01T14:46:27Z
2019-02-01T14:46:27Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv eXPRESS Polymer Letters
http://hdl.handle.net/20.500.12272/3408
10.3144/expresspolymlett.2015.52
identifier_str_mv eXPRESS Polymer Letters
10.3144/expresspolymlett.2015.52
url http://hdl.handle.net/20.500.12272/3408
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 12.712165

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