Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice

Autores
Andrini, Laura Beatriz; García, Marcela Nilda; Inda, Ana María; Errecalde, Ana Lía
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study we analyzed VEGF-C expression in regenerating liver (after partial hepactectomy) of ES2 hepatocellular carcinoma bearing mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h throughout one complete circadian cycle from 26 to 50 h post-hepatectomy. Tumor samples were processed for immunohistochemistry. The expression of VEGF was assessed according to the percentage of immunoreactive cells in a total of 1000 cells (quantitative analysis). The results show that controls and tumor bearing mice have statistical differences at all analysed time points, but the maximun value of VEGF expression of treated animals is significantly higher (p < 0.01) than the control group. We can conclude that when a partial hepatectomy is made with the purpose of eradicating a hepatic tumor, the presence of possible metastasis could release factors related with cellular proliferation that could increase the possibilities of tumoral recidives.
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/103915
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing miceAndrini, Laura BeatrizGarcía, Marcela NildaInda, Ana MaríaErrecalde, Ana LíaCiencias MédicasMouseLiverVEGFHepatocellular carcinomaCircadian rhythmsIn this study we analyzed VEGF-C expression in regenerating liver (after partial hepactectomy) of ES2 hepatocellular carcinoma bearing mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h throughout one complete circadian cycle from 26 to 50 h post-hepatectomy. Tumor samples were processed for immunohistochemistry. The expression of VEGF was assessed according to the percentage of immunoreactive cells in a total of 1000 cells (quantitative analysis). The results show that controls and tumor bearing mice have statistical differences at all analysed time points, but the maximun value of VEGF expression of treated animals is significantly higher (p < 0.01) than the control group. We can conclude that when a partial hepatectomy is made with the purpose of eradicating a hepatic tumor, the presence of possible metastasis could release factors related with cellular proliferation that could increase the possibilities of tumoral recidives.Facultad de Ciencias Médicas2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-6http://sedici.unlp.edu.ar/handle/10915/103915enginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/pdf/10.1080/09291010902863347info:eu-repo/semantics/altIdentifier/issn/1744-4179info:eu-repo/semantics/altIdentifier/doi/10.1080/09291010902863347info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:14:34Zoai:sedici.unlp.edu.ar:10915/103915Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:14:34.214SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
spellingShingle Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
Andrini, Laura Beatriz
Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
title_short Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_full Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_fullStr Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_full_unstemmed Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
title_sort Circadian rhythm of VEGF expression in the liver of hepatectomized tumor bearing mice
dc.creator.none.fl_str_mv Andrini, Laura Beatriz
García, Marcela Nilda
Inda, Ana María
Errecalde, Ana Lía
author Andrini, Laura Beatriz
author_facet Andrini, Laura Beatriz
García, Marcela Nilda
Inda, Ana María
Errecalde, Ana Lía
author_role author
author2 García, Marcela Nilda
Inda, Ana María
Errecalde, Ana Lía
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
topic Ciencias Médicas
Mouse
Liver
VEGF
Hepatocellular carcinoma
Circadian rhythms
dc.description.none.fl_txt_mv In this study we analyzed VEGF-C expression in regenerating liver (after partial hepactectomy) of ES2 hepatocellular carcinoma bearing mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h throughout one complete circadian cycle from 26 to 50 h post-hepatectomy. Tumor samples were processed for immunohistochemistry. The expression of VEGF was assessed according to the percentage of immunoreactive cells in a total of 1000 cells (quantitative analysis). The results show that controls and tumor bearing mice have statistical differences at all analysed time points, but the maximun value of VEGF expression of treated animals is significantly higher (p < 0.01) than the control group. We can conclude that when a partial hepatectomy is made with the purpose of eradicating a hepatic tumor, the presence of possible metastasis could release factors related with cellular proliferation that could increase the possibilities of tumoral recidives.
Facultad de Ciencias Médicas
description In this study we analyzed VEGF-C expression in regenerating liver (after partial hepactectomy) of ES2 hepatocellular carcinoma bearing mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h throughout one complete circadian cycle from 26 to 50 h post-hepatectomy. Tumor samples were processed for immunohistochemistry. The expression of VEGF was assessed according to the percentage of immunoreactive cells in a total of 1000 cells (quantitative analysis). The results show that controls and tumor bearing mice have statistical differences at all analysed time points, but the maximun value of VEGF expression of treated animals is significantly higher (p < 0.01) than the control group. We can conclude that when a partial hepatectomy is made with the purpose of eradicating a hepatic tumor, the presence of possible metastasis could release factors related with cellular proliferation that could increase the possibilities of tumoral recidives.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/103915
url http://sedici.unlp.edu.ar/handle/10915/103915
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/pdf/10.1080/09291010902863347
info:eu-repo/semantics/altIdentifier/issn/1744-4179
info:eu-repo/semantics/altIdentifier/doi/10.1080/09291010902863347
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1-6
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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