Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice

Autores
Fernández Blanco, Ayelén; Andrini, Laura Beatriz; Errecalde, Ana Lía; Inda, Ana María; García, Marcela Nilda
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We analyzed VEGF expression in regenerating liver (after partial hepatectomy) of tumor-bearing adult and young mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h, from 26 to 46 h post-hepatectomy. Liver samples were processed for immunohistochemistry. The results showed circadian variation of VEGF expression in hepatectomized mice (control group) and hepatectomized-tumor-bearing mice. The maximum value of VEGF expression was found at 16:00/30 h of day/hour post-hepatectomy (HD/HPH) in tumor-bearing young mice, and at 20:00/34 HD/HPH in the controls. In adult mice the maximum values of VEGF expression were at 16:00/30 HD/HPH in tumor-bearing mice, and at 08:00/46 HD/ HPH in the controls. Young tumor-bearing mice showed significantly higher mean values than the controls. In conclusion, the presence of the tumor in the animals induces modifications in the intensity and the temporal distribution of the circadian curves of VEGF expression.
Facultad de Ciencias Médicas
Materia
Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/103324
Acceder
id SEDICI_49d3b66b9b4b6051e405329448af21e0
oai_identifier_str oai:sedici.unlp.edu.ar:10915/103324
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young miceFernández Blanco, AyelénAndrini, Laura BeatrizErrecalde, Ana LíaInda, Ana MaríaGarcía, Marcela NildaCiencias MédicasMouseAgeHepatocellular carcinomaHepatectomyAngiogenesisWe analyzed VEGF expression in regenerating liver (after partial hepatectomy) of tumor-bearing adult and young mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h, from 26 to 46 h post-hepatectomy. Liver samples were processed for immunohistochemistry. The results showed circadian variation of VEGF expression in hepatectomized mice (control group) and hepatectomized-tumor-bearing mice. The maximum value of VEGF expression was found at 16:00/30 h of day/hour post-hepatectomy (HD/HPH) in tumor-bearing young mice, and at 20:00/34 HD/HPH in the controls. In adult mice the maximum values of VEGF expression were at 16:00/30 HD/HPH in tumor-bearing mice, and at 08:00/46 HD/ HPH in the controls. Young tumor-bearing mice showed significantly higher mean values than the controls. In conclusion, the presence of the tumor in the animals induces modifications in the intensity and the temporal distribution of the circadian curves of VEGF expression.Facultad de Ciencias Médicas2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/103324enginfo:eu-repo/semantics/altIdentifier/issn/1744-4179info:eu-repo/semantics/altIdentifier/doi/10.1080/09291016.2017.1377983info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:14:20Zoai:sedici.unlp.edu.ar:10915/103324Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:14:20.63SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
spellingShingle Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
Fernández Blanco, Ayelén
Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
title_short Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_full Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_fullStr Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_full_unstemmed Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
title_sort Circadian rhythm of VEGF expression in the liver of hepatectomized-tumor-bearing adult and young mice
dc.creator.none.fl_str_mv Fernández Blanco, Ayelén
Andrini, Laura Beatriz
Errecalde, Ana Lía
Inda, Ana María
García, Marcela Nilda
author Fernández Blanco, Ayelén
author_facet Fernández Blanco, Ayelén
Andrini, Laura Beatriz
Errecalde, Ana Lía
Inda, Ana María
García, Marcela Nilda
author_role author
author2 Andrini, Laura Beatriz
Errecalde, Ana Lía
Inda, Ana María
García, Marcela Nilda
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
topic Ciencias Médicas
Mouse
Age
Hepatocellular carcinoma
Hepatectomy
Angiogenesis
dc.description.none.fl_txt_mv We analyzed VEGF expression in regenerating liver (after partial hepatectomy) of tumor-bearing adult and young mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h, from 26 to 46 h post-hepatectomy. Liver samples were processed for immunohistochemistry. The results showed circadian variation of VEGF expression in hepatectomized mice (control group) and hepatectomized-tumor-bearing mice. The maximum value of VEGF expression was found at 16:00/30 h of day/hour post-hepatectomy (HD/HPH) in tumor-bearing young mice, and at 20:00/34 HD/HPH in the controls. In adult mice the maximum values of VEGF expression were at 16:00/30 HD/HPH in tumor-bearing mice, and at 08:00/46 HD/ HPH in the controls. Young tumor-bearing mice showed significantly higher mean values than the controls. In conclusion, the presence of the tumor in the animals induces modifications in the intensity and the temporal distribution of the circadian curves of VEGF expression.
Facultad de Ciencias Médicas
description We analyzed VEGF expression in regenerating liver (after partial hepatectomy) of tumor-bearing adult and young mice, throughout one complete circadian cycle. The animals were sacrificed every 4 h, from 26 to 46 h post-hepatectomy. Liver samples were processed for immunohistochemistry. The results showed circadian variation of VEGF expression in hepatectomized mice (control group) and hepatectomized-tumor-bearing mice. The maximum value of VEGF expression was found at 16:00/30 h of day/hour post-hepatectomy (HD/HPH) in tumor-bearing young mice, and at 20:00/34 HD/HPH in the controls. In adult mice the maximum values of VEGF expression were at 16:00/30 HD/HPH in tumor-bearing mice, and at 08:00/46 HD/ HPH in the controls. Young tumor-bearing mice showed significantly higher mean values than the controls. In conclusion, the presence of the tumor in the animals induces modifications in the intensity and the temporal distribution of the circadian curves of VEGF expression.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/103324
url http://sedici.unlp.edu.ar/handle/10915/103324
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1744-4179
info:eu-repo/semantics/altIdentifier/doi/10.1080/09291016.2017.1377983
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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