Circadian rhythms of proliferation events in two mouse carcinomas

Autores
Garcia, Marcela; Andrini, Laura Beatríz; Martinez, Marina; Inda, Ana; Palma, Maria Belen; Miriuka, Santiago Gabriel; Errecalde, Ana Lia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h shows significative differences, the TN60 has higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.
Fil: Garcia, Marcela. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Andrini, Laura Beatríz. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Martinez, Marina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Inda, Ana. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Palma, Maria Belen. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miriuka, Santiago Gabriel. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Errecalde, Ana Lia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Materia
Carcinoma
Circadian Rhythms
Dna Synthesis
Mice
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38465
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Circadian rhythms of proliferation events in two mouse carcinomasGarcia, MarcelaAndrini, Laura BeatrízMartinez, MarinaInda, AnaPalma, Maria BelenMiriuka, Santiago GabrielErrecalde, Ana LiaCarcinomaCircadian RhythmsDna SynthesisMicehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h shows significative differences, the TN60 has higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.Fil: Garcia, Marcela. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Andrini, Laura Beatríz. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Martinez, Marina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Inda, Ana. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Palma, Maria Belen. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miriuka, Santiago Gabriel. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Errecalde, Ana Lia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaTaylor & Francis Ltd2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38465Garcia, Marcela; Andrini, Laura Beatríz; Martinez, Marina; Inda, Ana; Palma, Maria Belen; et al.; Circadian rhythms of proliferation events in two mouse carcinomas; Taylor & Francis Ltd; Biological Rhythm Research; 46; 4; 7-2015; 573-5780929-1016CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/09291016.2015.1034971info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09291016.2015.1034971info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:41:04Zoai:ri.conicet.gov.ar:11336/38465instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:41:04.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circadian rhythms of proliferation events in two mouse carcinomas
title Circadian rhythms of proliferation events in two mouse carcinomas
spellingShingle Circadian rhythms of proliferation events in two mouse carcinomas
Garcia, Marcela
Carcinoma
Circadian Rhythms
Dna Synthesis
Mice
title_short Circadian rhythms of proliferation events in two mouse carcinomas
title_full Circadian rhythms of proliferation events in two mouse carcinomas
title_fullStr Circadian rhythms of proliferation events in two mouse carcinomas
title_full_unstemmed Circadian rhythms of proliferation events in two mouse carcinomas
title_sort Circadian rhythms of proliferation events in two mouse carcinomas
dc.creator.none.fl_str_mv Garcia, Marcela
Andrini, Laura Beatríz
Martinez, Marina
Inda, Ana
Palma, Maria Belen
Miriuka, Santiago Gabriel
Errecalde, Ana Lia
author Garcia, Marcela
author_facet Garcia, Marcela
Andrini, Laura Beatríz
Martinez, Marina
Inda, Ana
Palma, Maria Belen
Miriuka, Santiago Gabriel
Errecalde, Ana Lia
author_role author
author2 Andrini, Laura Beatríz
Martinez, Marina
Inda, Ana
Palma, Maria Belen
Miriuka, Santiago Gabriel
Errecalde, Ana Lia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Carcinoma
Circadian Rhythms
Dna Synthesis
Mice
topic Carcinoma
Circadian Rhythms
Dna Synthesis
Mice
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h shows significative differences, the TN60 has higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.
Fil: Garcia, Marcela. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Andrini, Laura Beatríz. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Martinez, Marina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Inda, Ana. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Palma, Maria Belen. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miriuka, Santiago Gabriel. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Errecalde, Ana Lia. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
description We studied the index of DNA synthesis (DNAs) of two cellular carcinomas: the hepatocellular ES12a and the mammary TN60 of mice, throughout one circadian cycle. In the results, we observed that both tumors have circadian rhythms (CRs), but the peaks of DNAs vary. Besides, the mean of DNAs along 24 h shows significative differences, the TN60 has higher values than the ES12a. These observed CR in the DNAs index in both carcinomas mean that, at least in partly, the proliferation of cancer cells can be regulated by endocrine factor as it normally occurs in ordinary cells. The big problem we can find for the chronopharmacology is that it is impossible to know in advance the rate of proliferation of each tumor.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38465
Garcia, Marcela; Andrini, Laura Beatríz; Martinez, Marina; Inda, Ana; Palma, Maria Belen; et al.; Circadian rhythms of proliferation events in two mouse carcinomas; Taylor & Francis Ltd; Biological Rhythm Research; 46; 4; 7-2015; 573-578
0929-1016
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38465
identifier_str_mv Garcia, Marcela; Andrini, Laura Beatríz; Martinez, Marina; Inda, Ana; Palma, Maria Belen; et al.; Circadian rhythms of proliferation events in two mouse carcinomas; Taylor & Francis Ltd; Biological Rhythm Research; 46; 4; 7-2015; 573-578
0929-1016
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/09291016.2015.1034971
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09291016.2015.1034971
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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