Sleep and circadian rhythm dysregulation in schizophrenia

Autores
Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; Cardinali, Daniel Pedro; Brown, Gregory M.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.
Fil: Monti, Jaime M.. Hospital de Clínicas. Departamento de Farmacología y Terapéutica; Uruguay
Fil: BaHammam, Ahmed S.. King Saud University. University Sleep Disorders Center; Arabia Saudita
Fil: Pandi-Perumal, Seithikurippu R.. Somnogen Canada Inc.; Canadá
Fil: Bromundt, Vivien. University of Basel. Psychiatric Hospital. Centre for Chronobiology; Suiza
Fil: Spence, D. Warren.
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brown, Gregory M.. University of Toronto. Centre for Addiction and Mental Health; Canadá
Materia
Circadian Rhythms
Schizophrenia
Sleep
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3858
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sleep and circadian rhythm dysregulation in schizophreniaMonti, Jaime M.BaHammam, Ahmed S.Pandi-Perumal, Seithikurippu R.Bromundt, VivienSpence, D. WarrenCardinali, Daniel PedroBrown, Gregory M.Circadian RhythmsSchizophreniaSleephttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.Fil: Monti, Jaime M.. Hospital de Clínicas. Departamento de Farmacología y Terapéutica; UruguayFil: BaHammam, Ahmed S.. King Saud University. University Sleep Disorders Center; Arabia SauditaFil: Pandi-Perumal, Seithikurippu R.. Somnogen Canada Inc.; CanadáFil: Bromundt, Vivien. University of Basel. Psychiatric Hospital. Centre for Chronobiology; SuizaFil: Spence, D. Warren.Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Brown, Gregory M.. University of Toronto. Centre for Addiction and Mental Health; CanadáElsevier2013-01-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3858Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; et al.; Sleep and circadian rhythm dysregulation in schizophrenia; Elsevier; Progress of Neuro-Psychopharmacology and Biological Psychiatry; 43; 11-1-2013; 209-2160278-5846enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584612003417info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2012.12.021info:eu-repo/semantics/altIdentifier/issn/0278-5846info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:32Zoai:ri.conicet.gov.ar:11336/3858instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:32.657CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sleep and circadian rhythm dysregulation in schizophrenia
title Sleep and circadian rhythm dysregulation in schizophrenia
spellingShingle Sleep and circadian rhythm dysregulation in schizophrenia
Monti, Jaime M.
Circadian Rhythms
Schizophrenia
Sleep
title_short Sleep and circadian rhythm dysregulation in schizophrenia
title_full Sleep and circadian rhythm dysregulation in schizophrenia
title_fullStr Sleep and circadian rhythm dysregulation in schizophrenia
title_full_unstemmed Sleep and circadian rhythm dysregulation in schizophrenia
title_sort Sleep and circadian rhythm dysregulation in schizophrenia
dc.creator.none.fl_str_mv Monti, Jaime M.
BaHammam, Ahmed S.
Pandi-Perumal, Seithikurippu R.
Bromundt, Vivien
Spence, D. Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
author Monti, Jaime M.
author_facet Monti, Jaime M.
BaHammam, Ahmed S.
Pandi-Perumal, Seithikurippu R.
Bromundt, Vivien
Spence, D. Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
author_role author
author2 BaHammam, Ahmed S.
Pandi-Perumal, Seithikurippu R.
Bromundt, Vivien
Spence, D. Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Circadian Rhythms
Schizophrenia
Sleep
topic Circadian Rhythms
Schizophrenia
Sleep
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.
Fil: Monti, Jaime M.. Hospital de Clínicas. Departamento de Farmacología y Terapéutica; Uruguay
Fil: BaHammam, Ahmed S.. King Saud University. University Sleep Disorders Center; Arabia Saudita
Fil: Pandi-Perumal, Seithikurippu R.. Somnogen Canada Inc.; Canadá
Fil: Bromundt, Vivien. University of Basel. Psychiatric Hospital. Centre for Chronobiology; Suiza
Fil: Spence, D. Warren.
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brown, Gregory M.. University of Toronto. Centre for Addiction and Mental Health; Canadá
description Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3858
Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; et al.; Sleep and circadian rhythm dysregulation in schizophrenia; Elsevier; Progress of Neuro-Psychopharmacology and Biological Psychiatry; 43; 11-1-2013; 209-216
0278-5846
url http://hdl.handle.net/11336/3858
identifier_str_mv Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; et al.; Sleep and circadian rhythm dysregulation in schizophrenia; Elsevier; Progress of Neuro-Psychopharmacology and Biological Psychiatry; 43; 11-1-2013; 209-216
0278-5846
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584612003417
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2012.12.021
info:eu-repo/semantics/altIdentifier/issn/0278-5846
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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