ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
- Autores
- Mandon, Elisabet C.; Tacconi de Gómez Dumm, Irma Nelva; Tacconi de Alaniz, María Josefa; Marra, Carlos Alberto; Brenner, Rodolfo Roberto
- Año de publicación
- 1987
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The in vivo and in vitro effect of ACTH on the biosynthesis of polyunsaturated fatty acid of rat adrenal gland and liver was studied. The administration of ACTH to intact rats produced a significant decrease in the conversion of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic acid to octadeca-6,9,12,15-tetraenoic acid, and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in liver and adrenal microsomes. Isolated adrenocortical cells and hepatocytes obtained from animals treated with ACTH showed a decrease in the incorporation and desaturation of exogenous [1-14C]eicosa-8,11,14-trienoic acid. The addition of ACTH to the incubation medium of adrenocortical cells and hepatocytes isolated from untreated rats also caused a decrease in delta 5 desaturation activity. The effect of ACTH on adrenal and liver desaturases could be produced as a consequence of the release of glucocorticoids, already measured in the experiments. However, the in vitro experiments carried out with hepatocytes isolated from untreated rats, where corticosterone was absent, indicated that ACTH can depress delta 5 desaturation per se.
Instituto de Investigaciones Bioquímicas de La Plata - Materia
-
Química
Biología
Linoleic acid
α-linolenic acid
Eicosa- 8,11,14-trienoic acid
Polyunsaturated fatty acids
Isolated adrenocortical cells
Hepatocytes - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/120450
Ver los metadatos del registro completo
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ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liverMandon, Elisabet C.Tacconi de Gómez Dumm, Irma NelvaTacconi de Alaniz, María JosefaMarra, Carlos AlbertoBrenner, Rodolfo RobertoQuímicaBiologíaLinoleic acidα-linolenic acidEicosa- 8,11,14-trienoic acidPolyunsaturated fatty acidsIsolated adrenocortical cellsHepatocytesThe in vivo and in vitro effect of ACTH on the biosynthesis of polyunsaturated fatty acid of rat adrenal gland and liver was studied. The administration of ACTH to intact rats produced a significant decrease in the conversion of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic acid to octadeca-6,9,12,15-tetraenoic acid, and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in liver and adrenal microsomes. Isolated adrenocortical cells and hepatocytes obtained from animals treated with ACTH showed a decrease in the incorporation and desaturation of exogenous [1-14C]eicosa-8,11,14-trienoic acid. The addition of ACTH to the incubation medium of adrenocortical cells and hepatocytes isolated from untreated rats also caused a decrease in delta 5 desaturation activity. The effect of ACTH on adrenal and liver desaturases could be produced as a consequence of the release of glucocorticoids, already measured in the experiments. However, the in vitro experiments carried out with hepatocytes isolated from untreated rats, where corticosterone was absent, indicated that ACTH can depress delta 5 desaturation per se.Instituto de Investigaciones Bioquímicas de La Plata1987info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1377-1383http://sedici.unlp.edu.ar/handle/10915/120450enginfo:eu-repo/semantics/altIdentifier/issn/0022-2275info:eu-repo/semantics/altIdentifier/doi/10.1016/S0022-2275(20)38570-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:28:30Zoai:sedici.unlp.edu.ar:10915/120450Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:28:30.597SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
title |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
spellingShingle |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver Mandon, Elisabet C. Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes |
title_short |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
title_full |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
title_fullStr |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
title_full_unstemmed |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
title_sort |
ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver |
dc.creator.none.fl_str_mv |
Mandon, Elisabet C. Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Marra, Carlos Alberto Brenner, Rodolfo Roberto |
author |
Mandon, Elisabet C. |
author_facet |
Mandon, Elisabet C. Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Marra, Carlos Alberto Brenner, Rodolfo Roberto |
author_role |
author |
author2 |
Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Marra, Carlos Alberto Brenner, Rodolfo Roberto |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes |
topic |
Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes |
dc.description.none.fl_txt_mv |
The in vivo and in vitro effect of ACTH on the biosynthesis of polyunsaturated fatty acid of rat adrenal gland and liver was studied. The administration of ACTH to intact rats produced a significant decrease in the conversion of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic acid to octadeca-6,9,12,15-tetraenoic acid, and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in liver and adrenal microsomes. Isolated adrenocortical cells and hepatocytes obtained from animals treated with ACTH showed a decrease in the incorporation and desaturation of exogenous [1-14C]eicosa-8,11,14-trienoic acid. The addition of ACTH to the incubation medium of adrenocortical cells and hepatocytes isolated from untreated rats also caused a decrease in delta 5 desaturation activity. The effect of ACTH on adrenal and liver desaturases could be produced as a consequence of the release of glucocorticoids, already measured in the experiments. However, the in vitro experiments carried out with hepatocytes isolated from untreated rats, where corticosterone was absent, indicated that ACTH can depress delta 5 desaturation per se. Instituto de Investigaciones Bioquímicas de La Plata |
description |
The in vivo and in vitro effect of ACTH on the biosynthesis of polyunsaturated fatty acid of rat adrenal gland and liver was studied. The administration of ACTH to intact rats produced a significant decrease in the conversion of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic acid to octadeca-6,9,12,15-tetraenoic acid, and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in liver and adrenal microsomes. Isolated adrenocortical cells and hepatocytes obtained from animals treated with ACTH showed a decrease in the incorporation and desaturation of exogenous [1-14C]eicosa-8,11,14-trienoic acid. The addition of ACTH to the incubation medium of adrenocortical cells and hepatocytes isolated from untreated rats also caused a decrease in delta 5 desaturation activity. The effect of ACTH on adrenal and liver desaturases could be produced as a consequence of the release of glucocorticoids, already measured in the experiments. However, the in vitro experiments carried out with hepatocytes isolated from untreated rats, where corticosterone was absent, indicated that ACTH can depress delta 5 desaturation per se. |
publishDate |
1987 |
dc.date.none.fl_str_mv |
1987 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/120450 |
url |
http://sedici.unlp.edu.ar/handle/10915/120450 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0022-2275 info:eu-repo/semantics/altIdentifier/doi/10.1016/S0022-2275(20)38570-9 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 1377-1383 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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