Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles
- Autores
- Ayala, Sixta; Gaspar, Graciela; Brenner, Rodolfo Roberto; Peluffo, Raúl Omar; Kunau, Wolf H.
- Año de publicación
- 1973
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages. It was demonstrated that testicular microsomes can desaturate and elongate linoleic and arachidonic acids in a manner similar to liver microsomes, and that testicular mitochondria can convert docosa-7,10,13,16-tetraenoic acid to arachidonic acid. Testicular or liver microsomes actively desaturate linoleic acid to γ-linolenic acid and eicosa-8,11,14-trienoic acid to arachidonic acid. However, it was impossible to measure in vitro any direct conversion of adrenic acid (22:4 [n – 6]) to docosapentaenoic acid (22: 5 [n – 6]) by either liver or testicular microsomes. Docosa-7,10,13,16-tetraenoic acid is incorporated preferentially into the triglyceride fraction of total testis, mitochondria, and microsomes, while linoleic and arachidonic acids are incorporated more into phospholipids. The capacity of testicular microsomes, but not of liver microsomes, to synthesize polyunsaturated fatty acids declines with age. It is proposed that the synthesis of acids of the linoleic family proceeds in two stages, a rapid one in which arachidonic acid is made and a second, slower, one in which C22 and C24 acids are synthesized. In addition, there appears to be a cycle between microsomes and mitochondria that acts to conserve essential polyunsaturated C20 and C22 fatty acids by means of synthesis and partial degradation, respectively. This cycle would restrict the loss of essential fatty acids and might be of importance for the supply of arachidonic acid in testis under specific requirements and especially in older animals.
Facultad de Ciencias Médicas - Materia
-
Ciencias Médicas
eicosa-8,11,14-trienoic acid
docosa-4,7,10,13,16-pentaenoic acid
fatty acid synthesis
fatty acid elongation
desaturation - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/122743
Ver los metadatos del registro completo
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Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testiclesAyala, SixtaGaspar, GracielaBrenner, Rodolfo RobertoPeluffo, Raúl OmarKunau, Wolf H.Ciencias Médicaseicosa-8,11,14-trienoic aciddocosa-4,7,10,13,16-pentaenoic acidfatty acid synthesisfatty acid elongationdesaturationA comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages. It was demonstrated that testicular microsomes can desaturate and elongate linoleic and arachidonic acids in a manner similar to liver microsomes, and that testicular mitochondria can convert docosa-7,10,13,16-tetraenoic acid to arachidonic acid. Testicular or liver microsomes actively desaturate linoleic acid to γ-linolenic acid and eicosa-8,11,14-trienoic acid to arachidonic acid. However, it was impossible to measure in vitro any direct conversion of adrenic acid (22:4 [n – 6]) to docosapentaenoic acid (22: 5 [n – 6]) by either liver or testicular microsomes. Docosa-7,10,13,16-tetraenoic acid is incorporated preferentially into the triglyceride fraction of total testis, mitochondria, and microsomes, while linoleic and arachidonic acids are incorporated more into phospholipids. The capacity of testicular microsomes, but not of liver microsomes, to synthesize polyunsaturated fatty acids declines with age. It is proposed that the synthesis of acids of the linoleic family proceeds in two stages, a rapid one in which arachidonic acid is made and a second, slower, one in which C<sub>22</sub> and C<sub>24</sub> acids are synthesized. In addition, there appears to be a cycle between microsomes and mitochondria that acts to conserve essential polyunsaturated C<sub>20</sub> and C<sub>22</sub> fatty acids by means of synthesis and partial degradation, respectively. This cycle would restrict the loss of essential fatty acids and might be of importance for the supply of arachidonic acid in testis under specific requirements and especially in older animals.Facultad de Ciencias Médicas1973-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf296-305http://sedici.unlp.edu.ar/handle/10915/122743enginfo:eu-repo/semantics/altIdentifier/issn/0022-2275info:eu-repo/semantics/altIdentifier/pmid/9704073info:eu-repo/semantics/altIdentifier/doi/10.1016/s0022-2275(20)36887-5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:14Zoai:sedici.unlp.edu.ar:10915/122743Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:15.078SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
title |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
spellingShingle |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles Ayala, Sixta Ciencias Médicas eicosa-8,11,14-trienoic acid docosa-4,7,10,13,16-pentaenoic acid fatty acid synthesis fatty acid elongation desaturation |
title_short |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
title_full |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
title_fullStr |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
title_full_unstemmed |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
title_sort |
Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles |
dc.creator.none.fl_str_mv |
Ayala, Sixta Gaspar, Graciela Brenner, Rodolfo Roberto Peluffo, Raúl Omar Kunau, Wolf H. |
author |
Ayala, Sixta |
author_facet |
Ayala, Sixta Gaspar, Graciela Brenner, Rodolfo Roberto Peluffo, Raúl Omar Kunau, Wolf H. |
author_role |
author |
author2 |
Gaspar, Graciela Brenner, Rodolfo Roberto Peluffo, Raúl Omar Kunau, Wolf H. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas eicosa-8,11,14-trienoic acid docosa-4,7,10,13,16-pentaenoic acid fatty acid synthesis fatty acid elongation desaturation |
topic |
Ciencias Médicas eicosa-8,11,14-trienoic acid docosa-4,7,10,13,16-pentaenoic acid fatty acid synthesis fatty acid elongation desaturation |
dc.description.none.fl_txt_mv |
A comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages. It was demonstrated that testicular microsomes can desaturate and elongate linoleic and arachidonic acids in a manner similar to liver microsomes, and that testicular mitochondria can convert docosa-7,10,13,16-tetraenoic acid to arachidonic acid. Testicular or liver microsomes actively desaturate linoleic acid to γ-linolenic acid and eicosa-8,11,14-trienoic acid to arachidonic acid. However, it was impossible to measure in vitro any direct conversion of adrenic acid (22:4 [n – 6]) to docosapentaenoic acid (22: 5 [n – 6]) by either liver or testicular microsomes. Docosa-7,10,13,16-tetraenoic acid is incorporated preferentially into the triglyceride fraction of total testis, mitochondria, and microsomes, while linoleic and arachidonic acids are incorporated more into phospholipids. The capacity of testicular microsomes, but not of liver microsomes, to synthesize polyunsaturated fatty acids declines with age. It is proposed that the synthesis of acids of the linoleic family proceeds in two stages, a rapid one in which arachidonic acid is made and a second, slower, one in which C<sub>22</sub> and C<sub>24</sub> acids are synthesized. In addition, there appears to be a cycle between microsomes and mitochondria that acts to conserve essential polyunsaturated C<sub>20</sub> and C<sub>22</sub> fatty acids by means of synthesis and partial degradation, respectively. This cycle would restrict the loss of essential fatty acids and might be of importance for the supply of arachidonic acid in testis under specific requirements and especially in older animals. Facultad de Ciencias Médicas |
description |
A comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages. It was demonstrated that testicular microsomes can desaturate and elongate linoleic and arachidonic acids in a manner similar to liver microsomes, and that testicular mitochondria can convert docosa-7,10,13,16-tetraenoic acid to arachidonic acid. Testicular or liver microsomes actively desaturate linoleic acid to γ-linolenic acid and eicosa-8,11,14-trienoic acid to arachidonic acid. However, it was impossible to measure in vitro any direct conversion of adrenic acid (22:4 [n – 6]) to docosapentaenoic acid (22: 5 [n – 6]) by either liver or testicular microsomes. Docosa-7,10,13,16-tetraenoic acid is incorporated preferentially into the triglyceride fraction of total testis, mitochondria, and microsomes, while linoleic and arachidonic acids are incorporated more into phospholipids. The capacity of testicular microsomes, but not of liver microsomes, to synthesize polyunsaturated fatty acids declines with age. It is proposed that the synthesis of acids of the linoleic family proceeds in two stages, a rapid one in which arachidonic acid is made and a second, slower, one in which C<sub>22</sub> and C<sub>24</sub> acids are synthesized. In addition, there appears to be a cycle between microsomes and mitochondria that acts to conserve essential polyunsaturated C<sub>20</sub> and C<sub>22</sub> fatty acids by means of synthesis and partial degradation, respectively. This cycle would restrict the loss of essential fatty acids and might be of importance for the supply of arachidonic acid in testis under specific requirements and especially in older animals. |
publishDate |
1973 |
dc.date.none.fl_str_mv |
1973-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/122743 |
url |
http://sedici.unlp.edu.ar/handle/10915/122743 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0022-2275 info:eu-repo/semantics/altIdentifier/pmid/9704073 info:eu-repo/semantics/altIdentifier/doi/10.1016/s0022-2275(20)36887-5 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
dc.format.none.fl_str_mv |
application/pdf 296-305 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
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