Standardizing training protocol of an intestinal transplantation model: A learning curve study

Autores
Azpiroz, Josefina; Abate Zárate, Juan Cruz; Andres Moreno, A.M.; Moreira, j; Hernandez Oliveros, F.; Raimondi, Jorge Clemente; Gondolesi, Gabriel Eduardo; Lausada, Natalia Raquel; Stringa, Pablo Luis
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Experimental: Rodent models of intestinal transplantation are crucial for advancing our understanding of various biological processes related to the procedure, including ischemia-reperfusion injury, acute cellular rejection and immunological tolerance, among others. These models also provide a platform for developing strategies and therapeutics aimed at improving long-term survival, with the ultimate goal of translating laboratory findings into clinical applications. With over twenty years of experience in intestinal transplantation in rodents, our team currently achieves a survival rate of 83 % in orthotopic transplants and 85 % in heterotopic transplants— success rates comparable to those reported by leading research groups in the field. This manuscript outlines the key steps involved in achieving successful results in rat intestinal transplantation models. It covers the entire process, from basic microsurgical training and graft procurement to implantation and postoperative care of the recipient. We hope this work will serve as a valuable guide for research groups seeking to establish these experimental transplantation models in their own laboratories.
Facultad de Ciencias Médicas
Instituto de Estudios Inmunológicos y Fisiopatológicos
Materia
Ciencias Médicas
Microsurgery
Research
Intestines
Transplant
Rats
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/182231
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/182231
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Standardizing training protocol of an intestinal transplantation model: A learning curve studyAzpiroz, JosefinaAbate Zárate, Juan CruzAndres Moreno, A.M.Moreira, jHernandez Oliveros, F.Raimondi, Jorge ClementeGondolesi, Gabriel EduardoLausada, Natalia RaquelStringa, Pablo LuisCiencias MédicasMicrosurgeryResearchIntestinesTransplantRatsExperimental: Rodent models of intestinal transplantation are crucial for advancing our understanding of various biological processes related to the procedure, including ischemia-reperfusion injury, acute cellular rejection and immunological tolerance, among others. These models also provide a platform for developing strategies and therapeutics aimed at improving long-term survival, with the ultimate goal of translating laboratory findings into clinical applications. With over twenty years of experience in intestinal transplantation in rodents, our team currently achieves a survival rate of 83 % in orthotopic transplants and 85 % in heterotopic transplants— success rates comparable to those reported by leading research groups in the field. This manuscript outlines the key steps involved in achieving successful results in rat intestinal transplantation models. It covers the entire process, from basic microsurgical training and graft procurement to implantation and postoperative care of the recipient. We hope this work will serve as a valuable guide for research groups seeking to establish these experimental transplantation models in their own laboratories.Facultad de Ciencias MédicasInstituto de Estudios Inmunológicos y Fisiopatológicos2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/182231enginfo:eu-repo/semantics/altIdentifier/issn/2950-4562info:eu-repo/semantics/altIdentifier/doi/10.1016/j.intf.2025.100060info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:21:34Zoai:sedici.unlp.edu.ar:10915/182231Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:21:35.073SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Standardizing training protocol of an intestinal transplantation model: A learning curve study
title Standardizing training protocol of an intestinal transplantation model: A learning curve study
spellingShingle Standardizing training protocol of an intestinal transplantation model: A learning curve study
Azpiroz, Josefina
Ciencias Médicas
Microsurgery
Research
Intestines
Transplant
Rats
title_short Standardizing training protocol of an intestinal transplantation model: A learning curve study
title_full Standardizing training protocol of an intestinal transplantation model: A learning curve study
title_fullStr Standardizing training protocol of an intestinal transplantation model: A learning curve study
title_full_unstemmed Standardizing training protocol of an intestinal transplantation model: A learning curve study
title_sort Standardizing training protocol of an intestinal transplantation model: A learning curve study
dc.creator.none.fl_str_mv Azpiroz, Josefina
Abate Zárate, Juan Cruz
Andres Moreno, A.M.
Moreira, j
Hernandez Oliveros, F.
Raimondi, Jorge Clemente
Gondolesi, Gabriel Eduardo
Lausada, Natalia Raquel
Stringa, Pablo Luis
author Azpiroz, Josefina
author_facet Azpiroz, Josefina
Abate Zárate, Juan Cruz
Andres Moreno, A.M.
Moreira, j
Hernandez Oliveros, F.
Raimondi, Jorge Clemente
Gondolesi, Gabriel Eduardo
Lausada, Natalia Raquel
Stringa, Pablo Luis
author_role author
author2 Abate Zárate, Juan Cruz
Andres Moreno, A.M.
Moreira, j
Hernandez Oliveros, F.
Raimondi, Jorge Clemente
Gondolesi, Gabriel Eduardo
Lausada, Natalia Raquel
Stringa, Pablo Luis
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Microsurgery
Research
Intestines
Transplant
Rats
topic Ciencias Médicas
Microsurgery
Research
Intestines
Transplant
Rats
dc.description.none.fl_txt_mv Experimental: Rodent models of intestinal transplantation are crucial for advancing our understanding of various biological processes related to the procedure, including ischemia-reperfusion injury, acute cellular rejection and immunological tolerance, among others. These models also provide a platform for developing strategies and therapeutics aimed at improving long-term survival, with the ultimate goal of translating laboratory findings into clinical applications. With over twenty years of experience in intestinal transplantation in rodents, our team currently achieves a survival rate of 83 % in orthotopic transplants and 85 % in heterotopic transplants— success rates comparable to those reported by leading research groups in the field. This manuscript outlines the key steps involved in achieving successful results in rat intestinal transplantation models. It covers the entire process, from basic microsurgical training and graft procurement to implantation and postoperative care of the recipient. We hope this work will serve as a valuable guide for research groups seeking to establish these experimental transplantation models in their own laboratories.
Facultad de Ciencias Médicas
Instituto de Estudios Inmunológicos y Fisiopatológicos
description Experimental: Rodent models of intestinal transplantation are crucial for advancing our understanding of various biological processes related to the procedure, including ischemia-reperfusion injury, acute cellular rejection and immunological tolerance, among others. These models also provide a platform for developing strategies and therapeutics aimed at improving long-term survival, with the ultimate goal of translating laboratory findings into clinical applications. With over twenty years of experience in intestinal transplantation in rodents, our team currently achieves a survival rate of 83 % in orthotopic transplants and 85 % in heterotopic transplants— success rates comparable to those reported by leading research groups in the field. This manuscript outlines the key steps involved in achieving successful results in rat intestinal transplantation models. It covers the entire process, from basic microsurgical training and graft procurement to implantation and postoperative care of the recipient. We hope this work will serve as a valuable guide for research groups seeking to establish these experimental transplantation models in their own laboratories.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/182231
url http://sedici.unlp.edu.ar/handle/10915/182231
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2950-4562
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.intf.2025.100060
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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