Gαi proteins are indispensable for hearing

• Autores: Beer-Hammer, Sandra; Lee, Sze Chim; Mauriac, Stephanie A.; Leiss, Veronika; Groh, Isabel A. M.; Novakovic, Ana; Piekorz, Roland P.; Bucher, Kirsten; Chen, Chengfang; Ni, Kun; Singer, Wibke; Harasztosi, Csaba; Schimmang, Thomas; Zimmermann, Ulrike; Pfeffer, Klaus; Birnbaumer, Lutz; Forge, Andrew; Montcouquiol, Mireille; Knipper, Marlies; Nürnberg, Bernd; Rüttiger, Lukas
• Año de publicación: 2018
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Cellular Physiology and Biochemistry. 2018;47(4):1509-1532
• Materia: GENES; AUDICION; PROTEINAS; SORDERA; PERDIDA AUDITIVA; MODIFICIACION GENETICA
• Institución: Pontificia Universidad Católica Argentina

Fil: Beer-Hammer, Sandra. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania
Fil: Lee, Sze Chim. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania
Fil: Mauriac, Stephanie A. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Francia
Fil: Mauriac, Stephanie A. University of Bordeaux. Neurocentre Magendie; Francia
Fil: Leiss, Veronika. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania
Fil: Groh, Isabel A. M. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania
Fil: Novakovic, Ana. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania
Fil: Piekorz, Roland P. University of Düsseldorf. Medical Faculty. Institute for Biochemistry and Molecular Biology II; Alemania
Fil: Bucher, Kirsten. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania
Fil: Chen, Chengfang. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania
Fil: Ni, Kun. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania
Fil: Singer, Wibke. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania
Fil: Harasztosi, Csaba. University of Tübingen. Section of Physiological Acoustics and Communication. Tübingen Hearing Research Center. Department of Otolaryngology; Alemania
Fil: Schimmang, Thomas. Universidad de Valladolid. Instituto de Biologíay Genética Molecular; España
Fil: Schimmang, Thomas. Consejo Superior de Investigaciones Científicas; España
Fil: Zimmermann, Ulrike. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. bMolecular Physiology of Hearing; Alemania
Fil: Pfeffer, Klaus. University of Düsseldorf. Institute of Medical Microbiology and Hospital Hygiene; Alemania
Fil: Birnbaumer, Lutz. Research Triangle Park. National Institute of Environmental Health Sciences, National Institute of Health. Neurobiology Laboratory; Estados Unidos
Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Forge, Andrew. University College London. Ear Institute; Reino Unido
Fil: Montcouquiol, Mireille. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Francia
Fil: Montcouquiol, Mireille. University of Bordeaux. Neurocentre Magendie; Francia
Fil: Knipper, Marlies. University of Tübingen. Department of Otolaryngology. Tübingen Hearing Research Centre. Molecular Physiology of Hearing; Alemania
Fil: Nürnberg, Bernd. University of Tübingen. Department of Pharmacology and Experimental Therapy. Interfaculty Center of Pharmacogenomics and Drug Research; Alemania
Fil: Rüttiger, Lukas. Institut National de la Santé et de la Recherche Médicale. Neurocentre Magendie; Francia
Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.