Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis

Autores
Scacchi Bernasconi, Pablo A.; Cardoso, Nancy P.; Reynoso, Roxana; Scacchi, Pablo; Cardinali, Daniel Pedro
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Cardoso, Nancy P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Abstract: Combinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats the increase in blood pressure (BP) after diet manipulation is sex-related and highly dependent on testosterone secretion. However, the extent of diet impact on rodent hypophysial-testicular axis remains undefined. In the present study rats drinking a 10% fructose solution or fed a high fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, with absence of significant changes in circulating follicle-stimulating hormone (FSH) or in weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an i.p. glucose tolerance test (IPGTT) and plasma lowdensity lipoprotein-cholesterol, cholesterol, triglycerides and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high fat-fed rats. Rather melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in the diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequels of rodent MS
Fuente
Preprint del documento publicado en Hormone molecular biology and clinical investigation 16(2), 2013
Materia
MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1644
Acceder
id RIUCA_93a8f3801e6d23381be2eeead05cd0ae
oai_identifier_str oai:ucacris:123456789/1644
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axisScacchi Bernasconi, Pablo A.Cardoso, Nancy P.Reynoso, RoxanaScacchi, PabloCardinali, Daniel PedroMELATONINASINDROME METABOLICOFRUCTOSADIETALHFSHHIPERTENSIONDISLIPIDEMIASTOLERANCIA A LA GLUCOSAACIDO URICOFil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Scacchi Bernasconi, Pablo A. Pontificia Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaFil: Cardoso, Nancy P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Reynoso, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaFil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; ArgentinaFil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaAbstract: Combinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats the increase in blood pressure (BP) after diet manipulation is sex-related and highly dependent on testosterone secretion. However, the extent of diet impact on rodent hypophysial-testicular axis remains undefined. In the present study rats drinking a 10% fructose solution or fed a high fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, with absence of significant changes in circulating follicle-stimulating hormone (FSH) or in weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an i.p. glucose tolerance test (IPGTT) and plasma lowdensity lipoprotein-cholesterol, cholesterol, triglycerides and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high fat-fed rats. Rather melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in the diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequels of rodent MSDe Gruyter2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16441868-1883 (impreso)1868-1891 (online)10.1515/hmbci-2013-0005Scacchi Barnasconi, P. A. Melatonin and diet-induced metabolic syndrome in rats : impact on the hypophysial-testicular axis [en línea]. Preprint del documento publicado en Hormone Molecular Biology and Clinical Investigation. 2013, 16 (2). doi:10.1515/hmbci-2013-0005. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1644Preprint del documento publicado en Hormone molecular biology and clinical investigation 16(2), 2013reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:21Zoai:ucacris:123456789/1644instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:21.842Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
spellingShingle Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
Scacchi Bernasconi, Pablo A.
MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
title_short Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_full Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_fullStr Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_full_unstemmed Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
title_sort Melatonin and diet-induced metabolic syndrome in rats. Impact on the hypophysial-testicular axis
dc.creator.none.fl_str_mv Scacchi Bernasconi, Pablo A.
Cardoso, Nancy P.
Reynoso, Roxana
Scacchi, Pablo
Cardinali, Daniel Pedro
author Scacchi Bernasconi, Pablo A.
author_facet Scacchi Bernasconi, Pablo A.
Cardoso, Nancy P.
Reynoso, Roxana
Scacchi, Pablo
Cardinali, Daniel Pedro
author_role author
author2 Cardoso, Nancy P.
Reynoso, Roxana
Scacchi, Pablo
Cardinali, Daniel Pedro
author2_role author
author
author
author
dc.subject.none.fl_str_mv MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
topic MELATONINA
SINDROME METABOLICO
FRUCTOSA
DIETA
LH
FSH
HIPERTENSION
DISLIPIDEMIAS
TOLERANCIA A LA GLUCOSA
ACIDO URICO
dc.description.none.fl_txt_mv Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Cardoso, Nancy P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
Fil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Abstract: Combinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats the increase in blood pressure (BP) after diet manipulation is sex-related and highly dependent on testosterone secretion. However, the extent of diet impact on rodent hypophysial-testicular axis remains undefined. In the present study rats drinking a 10% fructose solution or fed a high fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, with absence of significant changes in circulating follicle-stimulating hormone (FSH) or in weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an i.p. glucose tolerance test (IPGTT) and plasma lowdensity lipoprotein-cholesterol, cholesterol, triglycerides and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high fat-fed rats. Rather melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in the diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequels of rodent MS
description Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1644
1868-1883 (impreso)
1868-1891 (online)
10.1515/hmbci-2013-0005
Scacchi Barnasconi, P. A. Melatonin and diet-induced metabolic syndrome in rats : impact on the hypophysial-testicular axis [en línea]. Preprint del documento publicado en Hormone Molecular Biology and Clinical Investigation. 2013, 16 (2). doi:10.1515/hmbci-2013-0005. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1644
url https://repositorio.uca.edu.ar/handle/123456789/1644
identifier_str_mv 1868-1883 (impreso)
1868-1891 (online)
10.1515/hmbci-2013-0005
Scacchi Barnasconi, P. A. Melatonin and diet-induced metabolic syndrome in rats : impact on the hypophysial-testicular axis [en línea]. Preprint del documento publicado en Hormone Molecular Biology and Clinical Investigation. 2013, 16 (2). doi:10.1515/hmbci-2013-0005. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1644
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv Preprint del documento publicado en Hormone molecular biology and clinical investigation 16(2), 2013
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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