Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats

Autores
Cardinali, Daniel Pedro; Scacchi Bernasconi, Pablo A.; Reynoso, Roxana; Reyes Toso, Carlos F.; Scacchi, Pablo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Reyes Toso, Carlos F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases
Fuente
International journal of molecular sciences. 2013, 14
Materia
SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1639
Acceder
id RIUCA_4457d59b0ca6cb522410107ee3835da3
oai_identifier_str oai:ucacris:123456789/1639
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in ratsCardinali, Daniel PedroScacchi Bernasconi, Pablo A.Reynoso, RoxanaReyes Toso, Carlos F.Scacchi, PabloSINDROME METABOLICOMELATONINAHIPERTENSIONFRUCTOSADISLIPIDEMIAOBESIDADTOLERANCIA A LA GLUCOSAFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaFil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaFil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaFil: Reynoso, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaFil: Reyes Toso, Carlos F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; ArgentinaFil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaAbstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phasesMultidisciplinary Digital Publishing Institute2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16391661-6596 (impreso)1422-0067 (online)10.3390/ijms14022502Cardinali, D. P., et al. Melatonin may curtail the metabolic syndrome : studies on initial and fully established frucose-induced metabolic syndrome in rats [en línea]. International journal of molecular sciences. 2013, 14. doi:10.3390/ijms14022502. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1639International journal of molecular sciences. 2013, 14reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:21Zoai:ucacris:123456789/1639instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:21.818Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
spellingShingle Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
Cardinali, Daniel Pedro
SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
title_short Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_full Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_fullStr Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_full_unstemmed Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
title_sort Melatonin may curtail the metabolic syndrome : studies on initial and fully established fructose-induced metabolic syndrome in rats
dc.creator.none.fl_str_mv Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
author Cardinali, Daniel Pedro
author_facet Cardinali, Daniel Pedro
Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
author_role author
author2 Scacchi Bernasconi, Pablo A.
Reynoso, Roxana
Reyes Toso, Carlos F.
Scacchi, Pablo
author2_role author
author
author
author
dc.subject.none.fl_str_mv SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
topic SINDROME METABOLICO
MELATONINA
HIPERTENSION
FRUCTOSA
DISLIPIDEMIA
OBESIDAD
TOLERANCIA A LA GLUCOSA
dc.description.none.fl_txt_mv Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Reynoso, Roxana. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Reyes Toso, Carlos F. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina
Fil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Abstract: To examine the effect of melatonin given to rats simultaneously with fructose on initial and fully developed metabolic syndrome, male Wistar rats had free access to chow and 5% or 10% fructose drinking solution for 8 weeks. As compared to controls, systolic blood pressure augmented significantly under both treatments whereas excessive body weight was seen in rats receiving the 10% fructose only. Rats drinking 5% fructose showed a greater tolerance to a glucose load while rats having access to a 10% fructose drinking solution exhibited the expected impaired glucose tolerance found in the metabolic syndrome. Circulating triglyceride and low density lipoproteins-cholesterol (LDL-c) concentration augmented significantly in rats showing a fully developed metabolic syndrome only, while high blood cholesterol levels were found at both stages examined. Melatonin (25 μg/mL drinking solution) counteracted the changes in body weight and systolic blood pressure found in rats administered with fructose. Melatonin decreased the abnormal hyperglycemia seen after a glucose load in 10% fructose-treated rats but it did not modify the greater tolerance to glucose observed in animals drinking 5% fructose. Melatonin also counteracted the changes in plasma LDL-c, triglyceride and cholesterol levels and decreased plasma uric acid levels. The results underline a possible therapeutical role of melatonin in the metabolic syndrome, both at initial and established phases
description Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1639
1661-6596 (impreso)
1422-0067 (online)
10.3390/ijms14022502
Cardinali, D. P., et al. Melatonin may curtail the metabolic syndrome : studies on initial and fully established frucose-induced metabolic syndrome in rats [en línea]. International journal of molecular sciences. 2013, 14. doi:10.3390/ijms14022502. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1639
url https://repositorio.uca.edu.ar/handle/123456789/1639
identifier_str_mv 1661-6596 (impreso)
1422-0067 (online)
10.3390/ijms14022502
Cardinali, D. P., et al. Melatonin may curtail the metabolic syndrome : studies on initial and fully established frucose-induced metabolic syndrome in rats [en línea]. International journal of molecular sciences. 2013, 14. doi:10.3390/ijms14022502. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1639
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv International journal of molecular sciences. 2013, 14
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 13.13397

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