Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
- Autores
- Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; Ponzo, Osvaldo Juan; Pandolfi, Matias; Scacchi, Pablo; Reynoso, Roxana María
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.
Fil: Gámez, Juan Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Penalba, Romina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardoso, Nancy Patricia. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Scacchi Bernasconi, Pablo Antonio. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carbone, Silvia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción; Argentina
Fil: Ponzo, Osvaldo Juan. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Pandolfi, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Scacchi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Reynoso, Roxana María. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina - Materia
-
Bisphenol a Lh Fsh
Lh
Fsh
Estradiol
Prepubertal Rats
Folliculogenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/37648
Ver los metadatos del registro completo
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Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesisGámez, Juan ManuelPenalba, RominaCardoso, Nancy PatriciaScacchi Bernasconi, Pablo AntonioCarbone, Silvia ElenaPonzo, Osvaldo JuanPandolfi, MatiasScacchi, PabloReynoso, Roxana MaríaBisphenol a Lh FshLhFshEstradiolPrepubertal RatsFolliculogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.Fil: Gámez, Juan Manuel. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Penalba, Romina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Cardoso, Nancy Patricia. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Scacchi Bernasconi, Pablo Antonio. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carbone, Silvia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción; ArgentinaFil: Ponzo, Osvaldo Juan. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Pandolfi, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Scacchi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Reynoso, Roxana María. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaElsevier Science2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37648Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; et al.; Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis; Elsevier Science; Environmental Toxicology and Pharmacology; 39; 1; 1-2015; 9-151382-6689CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668914002518info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.10.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:18Zoai:ri.conicet.gov.ar:11336/37648instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:18.62CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
title |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
spellingShingle |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis Gámez, Juan Manuel Bisphenol a Lh Fsh Lh Fsh Estradiol Prepubertal Rats Folliculogenesis |
title_short |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
title_full |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
title_fullStr |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
title_full_unstemmed |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
title_sort |
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis |
dc.creator.none.fl_str_mv |
Gámez, Juan Manuel Penalba, Romina Cardoso, Nancy Patricia Scacchi Bernasconi, Pablo Antonio Carbone, Silvia Elena Ponzo, Osvaldo Juan Pandolfi, Matias Scacchi, Pablo Reynoso, Roxana María |
author |
Gámez, Juan Manuel |
author_facet |
Gámez, Juan Manuel Penalba, Romina Cardoso, Nancy Patricia Scacchi Bernasconi, Pablo Antonio Carbone, Silvia Elena Ponzo, Osvaldo Juan Pandolfi, Matias Scacchi, Pablo Reynoso, Roxana María |
author_role |
author |
author2 |
Penalba, Romina Cardoso, Nancy Patricia Scacchi Bernasconi, Pablo Antonio Carbone, Silvia Elena Ponzo, Osvaldo Juan Pandolfi, Matias Scacchi, Pablo Reynoso, Roxana María |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Bisphenol a Lh Fsh Lh Fsh Estradiol Prepubertal Rats Folliculogenesis |
topic |
Bisphenol a Lh Fsh Lh Fsh Estradiol Prepubertal Rats Folliculogenesis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats. Fil: Gámez, Juan Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Penalba, Romina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Cardoso, Nancy Patricia. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Scacchi Bernasconi, Pablo Antonio. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Carbone, Silvia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción; Argentina Fil: Ponzo, Osvaldo Juan. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Pandolfi, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina Fil: Scacchi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina Fil: Reynoso, Roxana María. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina |
description |
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/37648 Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; et al.; Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis; Elsevier Science; Environmental Toxicology and Pharmacology; 39; 1; 1-2015; 9-15 1382-6689 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/37648 |
identifier_str_mv |
Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; et al.; Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis; Elsevier Science; Environmental Toxicology and Pharmacology; 39; 1; 1-2015; 9-15 1382-6689 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668914002518 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.10.015 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268966095945728 |
score |
13.13397 |