Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis

Autores
Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; Ponzo, Osvaldo Juan; Pandolfi, Matias; Scacchi, Pablo; Reynoso, Roxana María
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.
Fil: Gámez, Juan Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Penalba, Romina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardoso, Nancy Patricia. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Scacchi Bernasconi, Pablo Antonio. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carbone, Silvia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción; Argentina
Fil: Ponzo, Osvaldo Juan. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Pandolfi, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Scacchi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Reynoso, Roxana María. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Materia
Bisphenol a Lh Fsh
Lh
Fsh
Estradiol
Prepubertal Rats
Folliculogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37648

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network_name_str CONICET Digital (CONICET)
spelling Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesisGámez, Juan ManuelPenalba, RominaCardoso, Nancy PatriciaScacchi Bernasconi, Pablo AntonioCarbone, Silvia ElenaPonzo, Osvaldo JuanPandolfi, MatiasScacchi, PabloReynoso, Roxana MaríaBisphenol a Lh FshLhFshEstradiolPrepubertal RatsFolliculogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.Fil: Gámez, Juan Manuel. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Penalba, Romina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Cardoso, Nancy Patricia. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Scacchi Bernasconi, Pablo Antonio. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carbone, Silvia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción; ArgentinaFil: Ponzo, Osvaldo Juan. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Pandolfi, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Scacchi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaFil: Reynoso, Roxana María. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; ArgentinaElsevier Science2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37648Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; et al.; Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis; Elsevier Science; Environmental Toxicology and Pharmacology; 39; 1; 1-2015; 9-151382-6689CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668914002518info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.10.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:18Zoai:ri.conicet.gov.ar:11336/37648instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:18.62CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
title Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
spellingShingle Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
Gámez, Juan Manuel
Bisphenol a Lh Fsh
Lh
Fsh
Estradiol
Prepubertal Rats
Folliculogenesis
title_short Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
title_full Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
title_fullStr Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
title_full_unstemmed Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
title_sort Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis
dc.creator.none.fl_str_mv Gámez, Juan Manuel
Penalba, Romina
Cardoso, Nancy Patricia
Scacchi Bernasconi, Pablo Antonio
Carbone, Silvia Elena
Ponzo, Osvaldo Juan
Pandolfi, Matias
Scacchi, Pablo
Reynoso, Roxana María
author Gámez, Juan Manuel
author_facet Gámez, Juan Manuel
Penalba, Romina
Cardoso, Nancy Patricia
Scacchi Bernasconi, Pablo Antonio
Carbone, Silvia Elena
Ponzo, Osvaldo Juan
Pandolfi, Matias
Scacchi, Pablo
Reynoso, Roxana María
author_role author
author2 Penalba, Romina
Cardoso, Nancy Patricia
Scacchi Bernasconi, Pablo Antonio
Carbone, Silvia Elena
Ponzo, Osvaldo Juan
Pandolfi, Matias
Scacchi, Pablo
Reynoso, Roxana María
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bisphenol a Lh Fsh
Lh
Fsh
Estradiol
Prepubertal Rats
Folliculogenesis
topic Bisphenol a Lh Fsh
Lh
Fsh
Estradiol
Prepubertal Rats
Folliculogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.
Fil: Gámez, Juan Manuel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Penalba, Romina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cardoso, Nancy Patricia. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Scacchi Bernasconi, Pablo Antonio. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carbone, Silvia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental. Laboratorio de Neuroendocrinología del Crecimiento y la Reproducción; Argentina
Fil: Ponzo, Osvaldo Juan. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Pandolfi, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Scacchi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina ; Argentina
Fil: Reynoso, Roxana María. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Pontificia Universidad Católica Argentina ; Argentina
description The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3 μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37648
Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; et al.; Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis; Elsevier Science; Environmental Toxicology and Pharmacology; 39; 1; 1-2015; 9-15
1382-6689
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37648
identifier_str_mv Gámez, Juan Manuel; Penalba, Romina; Cardoso, Nancy Patricia; Scacchi Bernasconi, Pablo Antonio; Carbone, Silvia Elena; et al.; Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: Effects on early folliculogenesis; Elsevier Science; Environmental Toxicology and Pharmacology; 39; 1; 1-2015; 9-15
1382-6689
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1382668914002518
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.etap.2014.10.015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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