Melatonin in septic shock : some recent concepts

Autores
Srinivasan, Venkataramanujan; Pandi Perumal, Seithikurippu R.; Cardinali, Daniel Pedro; Spence, David Warren; Kato, Hisanori
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Spence, David Warren. Investigador Independiente; Canadá
Fil: Kato, Hisanori. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Department of Applied Biological Chemistry; Japón
Abstract: Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiological role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control and regulation of mood. Melatonin has also been reported as effective in combating various bacterial and viral infections. Melatonin is an effective anti-inflammatory agent in various animal models of inflammation and sepsis and its anti-inflammatory action has been attributed to inhibition of nitric oxide synthase with consequent reduction of peroxynitrite formation, to the stimulation of various antioxidant enzymes thus contributing to enhance the antioxidant defense and to protective effects on mitochondrial function and in preventing apoptosis. In a number of animal models of septic shock, as well as in patients with septic disease, melatonin reportedly exerts beneficial effects to arrest cellular damage and multiorgan failure. The significance of these actions in septic shock and its potential usefulness in the treatment of multiorgan failure are discussed.
Fuente
Journal of Critical Care. 2010, 25
Materia
MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/1611
Acceder
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oai_identifier_str oai:ucacris:123456789/1611
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Melatonin in septic shock : some recent conceptsSrinivasan, VenkataramanujanPandi Perumal, Seithikurippu R.Cardinali, Daniel PedroSpence, David WarrenKato, HisanoriMELATONINAANTIOXIDANTESOXIDO NITRICOCITOCINASCHOQUE SEPTICOFil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; IndiaFil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados UnidosFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; ArgentinaFil: Spence, David Warren. Investigador Independiente; CanadáFil: Kato, Hisanori. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Department of Applied Biological Chemistry; JapónAbstract: Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiological role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control and regulation of mood. Melatonin has also been reported as effective in combating various bacterial and viral infections. Melatonin is an effective anti-inflammatory agent in various animal models of inflammation and sepsis and its anti-inflammatory action has been attributed to inhibition of nitric oxide synthase with consequent reduction of peroxynitrite formation, to the stimulation of various antioxidant enzymes thus contributing to enhance the antioxidant defense and to protective effects on mitochondrial function and in preventing apoptosis. In a number of animal models of septic shock, as well as in patients with septic disease, melatonin reportedly exerts beneficial effects to arrest cellular damage and multiorgan failure. The significance of these actions in septic shock and its potential usefulness in the treatment of multiorgan failure are discussed.Elsevier2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/16110883-944110.1016/j.jcrc.2010.03.006Srinivasan, V., et al. Melatonin in septic shock : some recent concepts. Preprint de artículo publicado en Journal of Critical Care. 2010, 25. doi:10.1016/j.jcrc.2010.03.006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1611Journal of Critical Care. 2010, 25reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaengenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:55:19Zoai:ucacris:123456789/1611instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:55:19.967Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Melatonin in septic shock : some recent concepts
title Melatonin in septic shock : some recent concepts
spellingShingle Melatonin in septic shock : some recent concepts
Srinivasan, Venkataramanujan
MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
title_short Melatonin in septic shock : some recent concepts
title_full Melatonin in septic shock : some recent concepts
title_fullStr Melatonin in septic shock : some recent concepts
title_full_unstemmed Melatonin in septic shock : some recent concepts
title_sort Melatonin in septic shock : some recent concepts
dc.creator.none.fl_str_mv Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Spence, David Warren
Kato, Hisanori
author Srinivasan, Venkataramanujan
author_facet Srinivasan, Venkataramanujan
Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Spence, David Warren
Kato, Hisanori
author_role author
author2 Pandi Perumal, Seithikurippu R.
Cardinali, Daniel Pedro
Spence, David Warren
Kato, Hisanori
author2_role author
author
author
author
dc.subject.none.fl_str_mv MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
topic MELATONINA
ANTIOXIDANTES
OXIDO NITRICO
CITOCINAS
CHOQUE SEPTICO
dc.description.none.fl_txt_mv Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina
Fil: Spence, David Warren. Investigador Independiente; Canadá
Fil: Kato, Hisanori. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Department of Applied Biological Chemistry; Japón
Abstract: Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiological role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control and regulation of mood. Melatonin has also been reported as effective in combating various bacterial and viral infections. Melatonin is an effective anti-inflammatory agent in various animal models of inflammation and sepsis and its anti-inflammatory action has been attributed to inhibition of nitric oxide synthase with consequent reduction of peroxynitrite formation, to the stimulation of various antioxidant enzymes thus contributing to enhance the antioxidant defense and to protective effects on mitochondrial function and in preventing apoptosis. In a number of animal models of septic shock, as well as in patients with septic disease, melatonin reportedly exerts beneficial effects to arrest cellular damage and multiorgan failure. The significance of these actions in septic shock and its potential usefulness in the treatment of multiorgan failure are discussed.
description Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/1611
0883-9441
10.1016/j.jcrc.2010.03.006
Srinivasan, V., et al. Melatonin in septic shock : some recent concepts. Preprint de artículo publicado en Journal of Critical Care. 2010, 25. doi:10.1016/j.jcrc.2010.03.006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1611
url https://repositorio.uca.edu.ar/handle/123456789/1611
identifier_str_mv 0883-9441
10.1016/j.jcrc.2010.03.006
Srinivasan, V., et al. Melatonin in septic shock : some recent concepts. Preprint de artículo publicado en Journal of Critical Care. 2010, 25. doi:10.1016/j.jcrc.2010.03.006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1611
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Journal of Critical Care. 2010, 25
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638330540785664
score 13.13397

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