Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering

Autores
Massone, Agustina
Año de publicación
2017
Idioma
inglés
Tipo de recurso
tesis de grado
Estado
versión borrador
Colaborador/a o director/a de tesis
Liverani, Liliana
Descripción
Nanofibers and nanomaterials are potentially recent additions to materials in relation to tissue engineering (TE). TE involves the regeneration of biological tissues, which are damaged, using cells with the aid of supporting structures and biomolecules. Mimicking the architecture and functions of extracellular matrix is one of the challenges for TE. Conventional treatments, such as transplantations and the use of mechanical assist devices, could be replaced with this approach. Electrospinning is a versatile and simple technique to produce polymer fibers with diameters varying from 5 nm to 5 μm, which can mimic the extracellular matrix. This characteristic stimulates the expression of specific signals and, in combination with growth factors and proteins, has an important influence in cellular activity. Blending synthetic with natural polymers, combine the advantages of both leading to good biodegradation and mechanical properties, and excellent cell adhesion and growth. In this work, it is presented the preparation and characterization of natural polymer (zein)-based nanofibrous scaffolds obtained through electrospinning technique. The processing parameters were adjusted to obtain randomly-oriented nanofibrous mats. Although the basic principles of the technique are simple, the many factors and parameters involved in it make the process complex. Through the analysis of testing results, it was found that the blend of zein with synthetic polymers improve in many folds its properties. The nanofibrous mats are of great interest for its applications in tissue engineering.
Fil: Massone, Agustina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Materia
Nanofibras
Nanomateriales
Ingeniería de tejidos
Ingeniería de tejidos (TE)
Electrospinning
Polímeros naturales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/4.0/
Repositorio
Repositorio Institucional Facultad de Ingeniería - UNMDP
Institución
Universidad Nacional de Mar del Plata. Facultad de Ingeniería
OAI Identificador
oai:rinfi.fi.mdp.edu.ar:123456789/311

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spelling Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineeringMassone, AgustinaNanofibrasNanomaterialesIngeniería de tejidosIngeniería de tejidos (TE)ElectrospinningPolímeros naturalesNanofibers and nanomaterials are potentially recent additions to materials in relation to tissue engineering (TE). TE involves the regeneration of biological tissues, which are damaged, using cells with the aid of supporting structures and biomolecules. Mimicking the architecture and functions of extracellular matrix is one of the challenges for TE. Conventional treatments, such as transplantations and the use of mechanical assist devices, could be replaced with this approach. Electrospinning is a versatile and simple technique to produce polymer fibers with diameters varying from 5 nm to 5 μm, which can mimic the extracellular matrix. This characteristic stimulates the expression of specific signals and, in combination with growth factors and proteins, has an important influence in cellular activity. Blending synthetic with natural polymers, combine the advantages of both leading to good biodegradation and mechanical properties, and excellent cell adhesion and growth. In this work, it is presented the preparation and characterization of natural polymer (zein)-based nanofibrous scaffolds obtained through electrospinning technique. The processing parameters were adjusted to obtain randomly-oriented nanofibrous mats. Although the basic principles of the technique are simple, the many factors and parameters involved in it make the process complex. Through the analysis of testing results, it was found that the blend of zein with synthetic polymers improve in many folds its properties. The nanofibrous mats are of great interest for its applications in tissue engineering.Fil: Massone, Agustina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaUniversidad Nacional de Mar del Plata. Facultad de Ingeniería. ArgentinaLiverani, Liliana2017-03-02Thesisinfo:eu-repo/semantics/draftinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1finfo:ar-repo/semantics/tesisDeGradoapplication/pdfhttp://rinfi.fi.mdp.edu.ar/xmlui/handle/123456789/311enginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/reponame:Repositorio Institucional Facultad de Ingeniería - UNMDPinstname:Universidad Nacional de Mar del Plata. Facultad de Ingeniería2025-09-29T15:02:38Zoai:rinfi.fi.mdp.edu.ar:123456789/311instacron:FI-UNMDPInstitucionalhttps://rinfi.fi.mdp.edu.ar/Universidad públicahttps://www.fi.mdp.edu.ar/https://rinfi.fi.mdp.edu.ar/oai/snrdjosemrvs@fi.mdp.edu.arArgentinaopendoar:2025-09-29 15:02:38.857Repositorio Institucional Facultad de Ingeniería - UNMDP - Universidad Nacional de Mar del Plata. Facultad de Ingenieríafalse
dc.title.none.fl_str_mv Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
title Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
spellingShingle Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
Massone, Agustina
Nanofibras
Nanomateriales
Ingeniería de tejidos
Ingeniería de tejidos (TE)
Electrospinning
Polímeros naturales
title_short Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
title_full Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
title_fullStr Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
title_full_unstemmed Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
title_sort Fabrication and characterization of electrospun zein-based scaffolds for soft tissue engineering
dc.creator.none.fl_str_mv Massone, Agustina
author Massone, Agustina
author_facet Massone, Agustina
author_role author
dc.contributor.none.fl_str_mv Liverani, Liliana
dc.subject.none.fl_str_mv Nanofibras
Nanomateriales
Ingeniería de tejidos
Ingeniería de tejidos (TE)
Electrospinning
Polímeros naturales
topic Nanofibras
Nanomateriales
Ingeniería de tejidos
Ingeniería de tejidos (TE)
Electrospinning
Polímeros naturales
dc.description.none.fl_txt_mv Nanofibers and nanomaterials are potentially recent additions to materials in relation to tissue engineering (TE). TE involves the regeneration of biological tissues, which are damaged, using cells with the aid of supporting structures and biomolecules. Mimicking the architecture and functions of extracellular matrix is one of the challenges for TE. Conventional treatments, such as transplantations and the use of mechanical assist devices, could be replaced with this approach. Electrospinning is a versatile and simple technique to produce polymer fibers with diameters varying from 5 nm to 5 μm, which can mimic the extracellular matrix. This characteristic stimulates the expression of specific signals and, in combination with growth factors and proteins, has an important influence in cellular activity. Blending synthetic with natural polymers, combine the advantages of both leading to good biodegradation and mechanical properties, and excellent cell adhesion and growth. In this work, it is presented the preparation and characterization of natural polymer (zein)-based nanofibrous scaffolds obtained through electrospinning technique. The processing parameters were adjusted to obtain randomly-oriented nanofibrous mats. Although the basic principles of the technique are simple, the many factors and parameters involved in it make the process complex. Through the analysis of testing results, it was found that the blend of zein with synthetic polymers improve in many folds its properties. The nanofibrous mats are of great interest for its applications in tissue engineering.
Fil: Massone, Agustina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
description Nanofibers and nanomaterials are potentially recent additions to materials in relation to tissue engineering (TE). TE involves the regeneration of biological tissues, which are damaged, using cells with the aid of supporting structures and biomolecules. Mimicking the architecture and functions of extracellular matrix is one of the challenges for TE. Conventional treatments, such as transplantations and the use of mechanical assist devices, could be replaced with this approach. Electrospinning is a versatile and simple technique to produce polymer fibers with diameters varying from 5 nm to 5 μm, which can mimic the extracellular matrix. This characteristic stimulates the expression of specific signals and, in combination with growth factors and proteins, has an important influence in cellular activity. Blending synthetic with natural polymers, combine the advantages of both leading to good biodegradation and mechanical properties, and excellent cell adhesion and growth. In this work, it is presented the preparation and characterization of natural polymer (zein)-based nanofibrous scaffolds obtained through electrospinning technique. The processing parameters were adjusted to obtain randomly-oriented nanofibrous mats. Although the basic principles of the technique are simple, the many factors and parameters involved in it make the process complex. Through the analysis of testing results, it was found that the blend of zein with synthetic polymers improve in many folds its properties. The nanofibrous mats are of great interest for its applications in tissue engineering.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-02
dc.type.none.fl_str_mv Thesis
info:eu-repo/semantics/draft
info:eu-repo/semantics/bachelorThesis
http://purl.org/coar/resource_type/c_7a1f
info:ar-repo/semantics/tesisDeGrado
status_str draft
format bachelorThesis
dc.identifier.none.fl_str_mv http://rinfi.fi.mdp.edu.ar/xmlui/handle/123456789/311
url http://rinfi.fi.mdp.edu.ar/xmlui/handle/123456789/311
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Argentina
publisher.none.fl_str_mv Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Argentina
dc.source.none.fl_str_mv reponame:Repositorio Institucional Facultad de Ingeniería - UNMDP
instname:Universidad Nacional de Mar del Plata. Facultad de Ingeniería
reponame_str Repositorio Institucional Facultad de Ingeniería - UNMDP
collection Repositorio Institucional Facultad de Ingeniería - UNMDP
instname_str Universidad Nacional de Mar del Plata. Facultad de Ingeniería
repository.name.fl_str_mv Repositorio Institucional Facultad de Ingeniería - UNMDP - Universidad Nacional de Mar del Plata. Facultad de Ingeniería
repository.mail.fl_str_mv josemrvs@fi.mdp.edu.ar
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