Reduced kinematic multiscale model for tissue engineering electrospun scaffolds

Autores
Caballero, Daniel Enrique; Montini Ballarin, Florencia; Gimenez, Juan Manuel; Biocca, Nicolás; Rull, Nahuel; Frontini, Patricia Maria; Urquiza, Santiago Adrian
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To this day, there is still a need for a direct relationship between the microscopic material properties and network microstructure configuration with the macroscopic mechanical response in order to optimize the design loops of biomimetic electrospun grafts. Multiscale mechanical modeling arises as a useful alternative, which allows to represent the individual nanofibers mechanical response and how the interaction between fibers results in the final macroscopic behavior. In this work, a micromechanical model that accounts for fiber interaction, progressive straightening (i.e. progressive recruitment) and reorientation is presented. An RVE is generated by means of a virtual deposition algorithm that mimics the electrospinning process itself, thus obtaining geometries that resemble the observed electrospun microstructure. These geometries were then validated by comparison with analysis of SEM images, taking special interest in the diameter, orientation and tortuosity distributions. Then, an elastic–plastic constitutive law for the nanofibers is implemented along with a simplified kinematic description that results in a significant reduction of the number of Degrees of Freedom of the discretized mechanical equilibrium problem. Finally, the micromechanical model is validated against uniaxial tensile tests of electrospun PLLA bone-shaped samples, reproducing the experimentally observed behavior while employing realistic geometric and constitutive parameters to characterize the fibers.
Fil: Caballero, Daniel Enrique. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Montini Ballarin, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Gimenez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Biocca, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Rull, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Frontini, Patricia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Urquiza, Santiago Adrian. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Materia
ELECTROSPINNING
MECHANICAL BEHAVIOR
MICROSTRUCTURE
MULTISCALE MODELING
SCAFFOLDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216412
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/216412
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Reduced kinematic multiscale model for tissue engineering electrospun scaffoldsCaballero, Daniel EnriqueMontini Ballarin, FlorenciaGimenez, Juan ManuelBiocca, NicolásRull, NahuelFrontini, Patricia MariaUrquiza, Santiago AdrianELECTROSPINNINGMECHANICAL BEHAVIORMICROSTRUCTUREMULTISCALE MODELINGSCAFFOLDShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2To this day, there is still a need for a direct relationship between the microscopic material properties and network microstructure configuration with the macroscopic mechanical response in order to optimize the design loops of biomimetic electrospun grafts. Multiscale mechanical modeling arises as a useful alternative, which allows to represent the individual nanofibers mechanical response and how the interaction between fibers results in the final macroscopic behavior. In this work, a micromechanical model that accounts for fiber interaction, progressive straightening (i.e. progressive recruitment) and reorientation is presented. An RVE is generated by means of a virtual deposition algorithm that mimics the electrospinning process itself, thus obtaining geometries that resemble the observed electrospun microstructure. These geometries were then validated by comparison with analysis of SEM images, taking special interest in the diameter, orientation and tortuosity distributions. Then, an elastic–plastic constitutive law for the nanofibers is implemented along with a simplified kinematic description that results in a significant reduction of the number of Degrees of Freedom of the discretized mechanical equilibrium problem. Finally, the micromechanical model is validated against uniaxial tensile tests of electrospun PLLA bone-shaped samples, reproducing the experimentally observed behavior while employing realistic geometric and constitutive parameters to characterize the fibers.Fil: Caballero, Daniel Enrique. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; ArgentinaFil: Montini Ballarin, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; ArgentinaFil: Gimenez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; ArgentinaFil: Biocca, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; ArgentinaFil: Rull, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Frontini, Patricia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Urquiza, Santiago Adrian. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; ArgentinaElsevier Science2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216412Caballero, Daniel Enrique; Montini Ballarin, Florencia; Gimenez, Juan Manuel; Biocca, Nicolás; Rull, Nahuel; et al.; Reduced kinematic multiscale model for tissue engineering electrospun scaffolds; Elsevier Science; Mechanics of Materials; 166; 3-2022; 1-360167-6636CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167663622000047info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mechmat.2022.104214info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:31Zoai:ri.conicet.gov.ar:11336/216412instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:31.731CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
title Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
spellingShingle Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
Caballero, Daniel Enrique
ELECTROSPINNING
MECHANICAL BEHAVIOR
MICROSTRUCTURE
MULTISCALE MODELING
SCAFFOLDS
title_short Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
title_full Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
title_fullStr Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
title_full_unstemmed Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
title_sort Reduced kinematic multiscale model for tissue engineering electrospun scaffolds
dc.creator.none.fl_str_mv Caballero, Daniel Enrique
Montini Ballarin, Florencia
Gimenez, Juan Manuel
Biocca, Nicolás
Rull, Nahuel
Frontini, Patricia Maria
Urquiza, Santiago Adrian
author Caballero, Daniel Enrique
author_facet Caballero, Daniel Enrique
Montini Ballarin, Florencia
Gimenez, Juan Manuel
Biocca, Nicolás
Rull, Nahuel
Frontini, Patricia Maria
Urquiza, Santiago Adrian
author_role author
author2 Montini Ballarin, Florencia
Gimenez, Juan Manuel
Biocca, Nicolás
Rull, Nahuel
Frontini, Patricia Maria
Urquiza, Santiago Adrian
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ELECTROSPINNING
MECHANICAL BEHAVIOR
MICROSTRUCTURE
MULTISCALE MODELING
SCAFFOLDS
topic ELECTROSPINNING
MECHANICAL BEHAVIOR
MICROSTRUCTURE
MULTISCALE MODELING
SCAFFOLDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv To this day, there is still a need for a direct relationship between the microscopic material properties and network microstructure configuration with the macroscopic mechanical response in order to optimize the design loops of biomimetic electrospun grafts. Multiscale mechanical modeling arises as a useful alternative, which allows to represent the individual nanofibers mechanical response and how the interaction between fibers results in the final macroscopic behavior. In this work, a micromechanical model that accounts for fiber interaction, progressive straightening (i.e. progressive recruitment) and reorientation is presented. An RVE is generated by means of a virtual deposition algorithm that mimics the electrospinning process itself, thus obtaining geometries that resemble the observed electrospun microstructure. These geometries were then validated by comparison with analysis of SEM images, taking special interest in the diameter, orientation and tortuosity distributions. Then, an elastic–plastic constitutive law for the nanofibers is implemented along with a simplified kinematic description that results in a significant reduction of the number of Degrees of Freedom of the discretized mechanical equilibrium problem. Finally, the micromechanical model is validated against uniaxial tensile tests of electrospun PLLA bone-shaped samples, reproducing the experimentally observed behavior while employing realistic geometric and constitutive parameters to characterize the fibers.
Fil: Caballero, Daniel Enrique. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Montini Ballarin, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Gimenez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Biocca, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
Fil: Rull, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Frontini, Patricia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Urquiza, Santiago Adrian. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Mecanica. Grupo de Ingeniería Asistida Por Computador; Argentina
description To this day, there is still a need for a direct relationship between the microscopic material properties and network microstructure configuration with the macroscopic mechanical response in order to optimize the design loops of biomimetic electrospun grafts. Multiscale mechanical modeling arises as a useful alternative, which allows to represent the individual nanofibers mechanical response and how the interaction between fibers results in the final macroscopic behavior. In this work, a micromechanical model that accounts for fiber interaction, progressive straightening (i.e. progressive recruitment) and reorientation is presented. An RVE is generated by means of a virtual deposition algorithm that mimics the electrospinning process itself, thus obtaining geometries that resemble the observed electrospun microstructure. These geometries were then validated by comparison with analysis of SEM images, taking special interest in the diameter, orientation and tortuosity distributions. Then, an elastic–plastic constitutive law for the nanofibers is implemented along with a simplified kinematic description that results in a significant reduction of the number of Degrees of Freedom of the discretized mechanical equilibrium problem. Finally, the micromechanical model is validated against uniaxial tensile tests of electrospun PLLA bone-shaped samples, reproducing the experimentally observed behavior while employing realistic geometric and constitutive parameters to characterize the fibers.
publishDate 2022
dc.date.none.fl_str_mv 2022-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216412
Caballero, Daniel Enrique; Montini Ballarin, Florencia; Gimenez, Juan Manuel; Biocca, Nicolás; Rull, Nahuel; et al.; Reduced kinematic multiscale model for tissue engineering electrospun scaffolds; Elsevier Science; Mechanics of Materials; 166; 3-2022; 1-36
0167-6636
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216412
identifier_str_mv Caballero, Daniel Enrique; Montini Ballarin, Florencia; Gimenez, Juan Manuel; Biocca, Nicolás; Rull, Nahuel; et al.; Reduced kinematic multiscale model for tissue engineering electrospun scaffolds; Elsevier Science; Mechanics of Materials; 166; 3-2022; 1-36
0167-6636
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167663622000047
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mechmat.2022.104214
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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