Finite Difference Model Representing Cell Distribution in Monolayer
- Autores
- Acerbo, Esteban; Bellotti, Mariela Ines; Bonetto, Fabian
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión aceptada
- Descripción
- Fil: Acerbo, Esteban. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Técnologicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, Argentina
Fil: Bellotti, Mariela Ines. Universidad Nacional de Río Negro. Sede Andina. Carrera de Medicina. Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Laboratorio de Cavitación y Biotecnología. Argentina
Fil: Bonetto, Fabian. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Tecnológicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, Argentina
In this work we developed a finite difference algorithm to calculate the spectral impedance of any distribution of square cells over an electrode. Allowing to simulate assays evolution, cell death dynamics, different cell morphologies and any electrode shape. The spectral impedance is calculated as a function of alpha, Rb and Cm. The same parameters proposed by Giaever and Keese to analytically model a confluent culture over an infinite electrode [1]. Using the same parameters allows us to compare the simulation results of a non-confluent culture to its confluent equivalent. As seen in the Figure, a simulation resume of a culture with 75% alive – 25% dead cells emplaced randomly. The results show the system spectral impedance between the bare electrode (100% dead cells) and GK model (100% alive cells) as expected. This model is aimed to estimate the cell population above the electrode by contrasting simulations with experimental measurements. For this it is necessary to simulate different cell distributions or assay evolutions, using a range of parameter to compare before the measurement as each simulation is computationally expensive. - Materia
-
Ciencias Médicas y de la Salud
Algorithm
Impedance spectral
cell
Ciencias Médicas y de la Salud - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de Río Negro
- OAI Identificador
- oai:rid.unrn.edu.ar:20.500.12049/13461
Ver los metadatos del registro completo
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Finite Difference Model Representing Cell Distribution in MonolayerAcerbo, EstebanBellotti, Mariela InesBonetto, FabianCiencias Médicas y de la SaludAlgorithmImpedance spectralcellCiencias Médicas y de la SaludFil: Acerbo, Esteban. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Técnologicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, ArgentinaFil: Bellotti, Mariela Ines. Universidad Nacional de Río Negro. Sede Andina. Carrera de Medicina. Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Laboratorio de Cavitación y Biotecnología. ArgentinaFil: Bonetto, Fabian. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Tecnológicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, ArgentinaIn this work we developed a finite difference algorithm to calculate the spectral impedance of any distribution of square cells over an electrode. Allowing to simulate assays evolution, cell death dynamics, different cell morphologies and any electrode shape. The spectral impedance is calculated as a function of alpha, Rb and Cm. The same parameters proposed by Giaever and Keese to analytically model a confluent culture over an infinite electrode [1]. Using the same parameters allows us to compare the simulation results of a non-confluent culture to its confluent equivalent. As seen in the Figure, a simulation resume of a culture with 75% alive – 25% dead cells emplaced randomly. The results show the system spectral impedance between the bare electrode (100% dead cells) and GK model (100% alive cells) as expected. This model is aimed to estimate the cell population above the electrode by contrasting simulations with experimental measurements. For this it is necessary to simulate different cell distributions or assay evolutions, using a range of parameter to compare before the measurement as each simulation is computationally expensive.2025-09-17info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://rid.unrn.edu.ar/handle/20.500.12049/13461eng6th Conference on Impedance-Based Cellular Assays (IBCA), Super C, Universidad RWTH Aachen, Alemania1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/reponame:RID-UNRN (UNRN)instname:Universidad Nacional de Río Negro2025-09-29T14:29:23Zoai:rid.unrn.edu.ar:20.500.12049/13461instacron:UNRNInstitucionalhttps://rid.unrn.edu.ar/jspui/Universidad públicaNo correspondehttps://rid.unrn.edu.ar/oai/snrdrid@unrn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:43692025-09-29 14:29:23.846RID-UNRN (UNRN) - Universidad Nacional de Río Negrofalse |
dc.title.none.fl_str_mv |
Finite Difference Model Representing Cell Distribution in Monolayer |
title |
Finite Difference Model Representing Cell Distribution in Monolayer |
spellingShingle |
Finite Difference Model Representing Cell Distribution in Monolayer Acerbo, Esteban Ciencias Médicas y de la Salud Algorithm Impedance spectral cell Ciencias Médicas y de la Salud |
title_short |
Finite Difference Model Representing Cell Distribution in Monolayer |
title_full |
Finite Difference Model Representing Cell Distribution in Monolayer |
title_fullStr |
Finite Difference Model Representing Cell Distribution in Monolayer |
title_full_unstemmed |
Finite Difference Model Representing Cell Distribution in Monolayer |
title_sort |
Finite Difference Model Representing Cell Distribution in Monolayer |
dc.creator.none.fl_str_mv |
Acerbo, Esteban Bellotti, Mariela Ines Bonetto, Fabian |
author |
Acerbo, Esteban |
author_facet |
Acerbo, Esteban Bellotti, Mariela Ines Bonetto, Fabian |
author_role |
author |
author2 |
Bellotti, Mariela Ines Bonetto, Fabian |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas y de la Salud Algorithm Impedance spectral cell Ciencias Médicas y de la Salud |
topic |
Ciencias Médicas y de la Salud Algorithm Impedance spectral cell Ciencias Médicas y de la Salud |
dc.description.none.fl_txt_mv |
Fil: Acerbo, Esteban. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Técnologicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, Argentina Fil: Bellotti, Mariela Ines. Universidad Nacional de Río Negro. Sede Andina. Carrera de Medicina. Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche. Laboratorio de Cavitación y Biotecnología. Argentina Fil: Bonetto, Fabian. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Tecnológicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, Argentina In this work we developed a finite difference algorithm to calculate the spectral impedance of any distribution of square cells over an electrode. Allowing to simulate assays evolution, cell death dynamics, different cell morphologies and any electrode shape. The spectral impedance is calculated as a function of alpha, Rb and Cm. The same parameters proposed by Giaever and Keese to analytically model a confluent culture over an infinite electrode [1]. Using the same parameters allows us to compare the simulation results of a non-confluent culture to its confluent equivalent. As seen in the Figure, a simulation resume of a culture with 75% alive – 25% dead cells emplaced randomly. The results show the system spectral impedance between the bare electrode (100% dead cells) and GK model (100% alive cells) as expected. This model is aimed to estimate the cell population above the electrode by contrasting simulations with experimental measurements. For this it is necessary to simulate different cell distributions or assay evolutions, using a range of parameter to compare before the measurement as each simulation is computationally expensive. |
description |
Fil: Acerbo, Esteban. Laboratorio de Cavitación y Biotecnología, Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina . Comisión Nacional de Energía Atómica (CNEA), Centro Atómico Bariloche, San Carlos de Bariloche, R8402AGP, Argentina c Consejo Nacional de Investigaciones Ciencia y Técnologicas (CONICET), Buenos Aires, C1033AAJ, Argentina d Universidad Nacional de Cuyo Instituto Balseiro, San Carlos de Bariloche, R8402AGP, Argentina |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-09-17 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/acceptedVersion http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
format |
conferenceObject |
status_str |
acceptedVersion |
dc.identifier.none.fl_str_mv |
http://rid.unrn.edu.ar/handle/20.500.12049/13461 |
url |
http://rid.unrn.edu.ar/handle/20.500.12049/13461 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
6th Conference on Impedance-Based Cellular Assays (IBCA), Super C, Universidad RWTH Aachen, Alemania1 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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application/pdf |
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reponame:RID-UNRN (UNRN) instname:Universidad Nacional de Río Negro |
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RID-UNRN (UNRN) |
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RID-UNRN (UNRN) |
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Universidad Nacional de Río Negro |
repository.name.fl_str_mv |
RID-UNRN (UNRN) - Universidad Nacional de Río Negro |
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rid@unrn.edu.ar |
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