Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function
- Autores
- Kembro, Jackelyn Melissa
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina.
The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them.
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina.
Biofísica - Materia
-
Química biológica
Redes mitocondriales
Reactive oxygen species [ROS]
Investigaciones biológicas - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
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- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/547217
Ver los metadatos del registro completo
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Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial functionKembro, Jackelyn MelissaQuímica biológicaRedes mitocondrialesReactive oxygen species [ROS]Investigaciones biológicasFil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina.The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them.Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina.Biofísica2014info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/547217enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-23T11:15:10Zoai:rdu.unc.edu.ar:11086/547217Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-23 11:15:10.999Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
| dc.title.none.fl_str_mv |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| spellingShingle |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function Kembro, Jackelyn Melissa Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas |
| title_short |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_full |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_fullStr |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_full_unstemmed |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| title_sort |
Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function |
| dc.creator.none.fl_str_mv |
Kembro, Jackelyn Melissa |
| author |
Kembro, Jackelyn Melissa |
| author_facet |
Kembro, Jackelyn Melissa |
| author_role |
author |
| dc.subject.none.fl_str_mv |
Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas |
| topic |
Química biológica Redes mitocondriales Reactive oxygen species [ROS] Investigaciones biológicas |
| dc.description.none.fl_txt_mv |
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. The time-keeping properties bestowed by oscillatory behavior on functional rhythms represent an evolutionarily conserved trait in living systems. Mitochondrial networks function as timekeepers maximizing energetic output while tuning reactive oxygen species [ROS] within physiological levels compatible with signaling. In this work, we explore the potential for timekeeping functions dependent on mitochondrial dynamics with the validated two-compartment mitochondrial energetic-redox (ME-R) computational model, that takes into account (a) four main redox couples (NADH, NADPH, GSH, Trx(SH)2), (b) scavenging systems (glutathione, thioredoxin, SOD, catalase) distributed in matrix and extra-matrix compartments, and (c) transport of ROS species between them. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Biofísica |
| description |
Fil: Kembro, Jackelyn Melissa. Universidad Nacional de Córdoba. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 |
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publishedVersion |
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http://hdl.handle.net/11086/547217 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba |
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