Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability

Autores
Kembro, Jackelyn Melissa; Cortassa, Sonia del Carmen; Lloyd, David; Sollott, Steven J.; Aon, Miguel A.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the “edge” between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the “edge” mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.
Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina
Fil: Cortassa, Sonia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute on Aging; Estados Unidos
Fil: Lloyd, David. Cardiff University; Reino Unido
Fil: Sollott, Steven J.. National Institute on Aging; Estados Unidos
Fil: Aon, Miguel A.. National Institute on Aging; Estados Unidos
Materia
MITOCHONDRIAL DYNAMICS
CHAOS
LYAPUNOV EXPONENTE
STRANGE ATRACTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87055
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stabilityKembro, Jackelyn MelissaCortassa, Sonia del CarmenLloyd, DavidSollott, Steven J.Aon, Miguel A.MITOCHONDRIAL DYNAMICSCHAOSLYAPUNOV EXPONENTESTRANGE ATRACTORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the “edge” between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the “edge” mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; ArgentinaFil: Cortassa, Sonia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute on Aging; Estados UnidosFil: Lloyd, David. Cardiff University; Reino UnidoFil: Sollott, Steven J.. National Institute on Aging; Estados UnidosFil: Aon, Miguel A.. National Institute on Aging; Estados UnidosNature Publishing Group2018-12-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87055Kembro, Jackelyn Melissa; Cortassa, Sonia del Carmen; Lloyd, David; Sollott, Steven J.; Aon, Miguel A.; Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability; Nature Publishing Group; Scientific Reports; 8; 1; 18-12-20182045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-33582-winfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-33582-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:14:36Zoai:ri.conicet.gov.ar:11336/87055instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:14:36.284CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
spellingShingle Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
Kembro, Jackelyn Melissa
MITOCHONDRIAL DYNAMICS
CHAOS
LYAPUNOV EXPONENTE
STRANGE ATRACTOR
title_short Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_full Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_fullStr Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_full_unstemmed Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
title_sort Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
dc.creator.none.fl_str_mv Kembro, Jackelyn Melissa
Cortassa, Sonia del Carmen
Lloyd, David
Sollott, Steven J.
Aon, Miguel A.
author Kembro, Jackelyn Melissa
author_facet Kembro, Jackelyn Melissa
Cortassa, Sonia del Carmen
Lloyd, David
Sollott, Steven J.
Aon, Miguel A.
author_role author
author2 Cortassa, Sonia del Carmen
Lloyd, David
Sollott, Steven J.
Aon, Miguel A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv MITOCHONDRIAL DYNAMICS
CHAOS
LYAPUNOV EXPONENTE
STRANGE ATRACTOR
topic MITOCHONDRIAL DYNAMICS
CHAOS
LYAPUNOV EXPONENTE
STRANGE ATRACTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the “edge” between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the “edge” mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.
Fil: Kembro, Jackelyn Melissa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Ciencias y Tecnología de los Alimentos; Argentina
Fil: Cortassa, Sonia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. National Institute on Aging; Estados Unidos
Fil: Lloyd, David. Cardiff University; Reino Unido
Fil: Sollott, Steven J.. National Institute on Aging; Estados Unidos
Fil: Aon, Miguel A.. National Institute on Aging; Estados Unidos
description Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is that biological network stability/instability can play critical roles in determining health and disease. We report for the first-time mitochondrial chaotic dynamics, characterizing the conditions leading from stability to chaos in this organelle. Using an experimentally validated computational model of mitochondrial function, we show that complex oscillatory dynamics in key metabolic variables, arising at the “edge” between fully functional and pathological behavior, sets the stage for chaos. Under these conditions, a mild, regular sinusoidal redox forcing perturbation triggers chaotic dynamics with main signature traits such as sensitivity to initial conditions, positive Lyapunov exponents, and strange attractors. At the “edge” mitochondrial chaos is exquisitely sensitive to the antioxidant capacity of matrix Mn superoxide dismutase as well as to the amplitude and frequency of the redox perturbation. These results have potential implications both for mitochondrial signaling determining health maintenance, and pathological transformation, including abnormal cardiac rhythms.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-18
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87055
Kembro, Jackelyn Melissa; Cortassa, Sonia del Carmen; Lloyd, David; Sollott, Steven J.; Aon, Miguel A.; Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability; Nature Publishing Group; Scientific Reports; 8; 1; 18-12-2018
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87055
identifier_str_mv Kembro, Jackelyn Melissa; Cortassa, Sonia del Carmen; Lloyd, David; Sollott, Steven J.; Aon, Miguel A.; Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability; Nature Publishing Group; Scientific Reports; 8; 1; 18-12-2018
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-33582-w
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-33582-w
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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