Renin-angiotensin sistem modulating funtions in the cpu

Autores
Bregonzio, Claudia; Baiardi, Gustavo; Marinzalda, M. A; Paz, María Constanza
Año de publicación
2014
Idioma
inglés
Tipo de recurso
parte de libro
Estado
versión publicada
Descripción
Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.
Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Marinzalda, M. A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacología; Argentina.
Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacologia; Argentina.
Fil: Paz, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Paz, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
The caudate-putamen (CPu) of the striatum is one of the main entrances to the basal ganglia. The CPu is fundamentally a dopaminergic area receiving dopamine innervation from the substantia nigra, ventral tegmental area, and mesencephalic structures, but also has noradrenergic inputs from a post-encephalic area, the locus coeruleus, and glutamatergic innervation from cortical structures and cholinergic and GABAergic interneurons. It is well known that functional interactions between different neurotransmission systems play a crucial integrative role in the caudate-putamen, and are widely recognized as contributing to central motor activity and movements, and also to the processing of cognitive and limbic functions, despite autonomic responses across the noradrenergic system. Not only does typical neurotransmission regulate these functions, but peptidergic systems also have an important role. The brain renin-angiotensin system (RAS) is involved not only in the regulation of blood pressure, but also in the modulation of multiple additional functions in the brain, including processes of sensory information, learning and memory, and the regulation of emotional and behavioral responses. There is increasing ontogenetic, anatomic and functional evidence of the existence of a brain renin-angiotensin system and of its interaction with other putative neurotransmitters and their receptors. All components of the RAS have been observed in the striatum, and Ang II modulates dopamine release from striatal dopaminergic terminals, in vivo and in vitro, via their AT1 receptors. There is considerable evidence supporting a key role for dopamine (DA) neurotransmission in the Cpu in long-term neuroadaptative changes induced by stress or psychostimulants, such as cocaine or amphetamine. Repeated amphetamine or cocaine administration results in progressive and enduring enhancement of their psychomotor and positive reinforcing effects (sensitization phenomenon). We recently found evidence of the participation of Ang II, through its AT1 receptors, in the development of the locomotor sensitization induced by psychostimulant drugs. Moreover, the brain RAS may play a role in the pathogenesis and progression of Parkinson?s disease and aging-related loss of DA neurons. Manipulation of RAS components may be useful for neuroprotection in Parkinson?s disease patients because local RAS plays a major role in proinflammatory and pro-oxidative changes in aged substantia nigra. RAS is involved in modulating neurotransmission systems in the CPu and their functions, and for this reason it could be a possible target in the treatment of stress related diseases, drug abuse or neurodegenerative disorders.
http://www.novapublishers.com/catalog/product_info.
Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.
Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Marinzalda, M. A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacología; Argentina.
Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacologia; Argentina.
Fil: Paz, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Paz, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Neurociencias (incluye Psicofiosiología)
Materia
Angiotensin
Brain ras
Caudate putamen
At1 receptors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/29950

id RDUUNC_a87aa1aea4842ab9d7442fb842fa45b2
oai_identifier_str oai:rdu.unc.edu.ar:11086/29950
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Renin-angiotensin sistem modulating funtions in the cpuBregonzio, ClaudiaBaiardi, GustavoMarinzalda, M. APaz, María ConstanzaAngiotensinBrain rasCaudate putamenAt1 receptorsFil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.Fil: Marinzalda, M. A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacología; Argentina.Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacologia; Argentina.Fil: Paz, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.Fil: Paz, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaThe caudate-putamen (CPu) of the striatum is one of the main entrances to the basal ganglia. The CPu is fundamentally a dopaminergic area receiving dopamine innervation from the substantia nigra, ventral tegmental area, and mesencephalic structures, but also has noradrenergic inputs from a post-encephalic area, the locus coeruleus, and glutamatergic innervation from cortical structures and cholinergic and GABAergic interneurons. It is well known that functional interactions between different neurotransmission systems play a crucial integrative role in the caudate-putamen, and are widely recognized as contributing to central motor activity and movements, and also to the processing of cognitive and limbic functions, despite autonomic responses across the noradrenergic system. Not only does typical neurotransmission regulate these functions, but peptidergic systems also have an important role. The brain renin-angiotensin system (RAS) is involved not only in the regulation of blood pressure, but also in the modulation of multiple additional functions in the brain, including processes of sensory information, learning and memory, and the regulation of emotional and behavioral responses. There is increasing ontogenetic, anatomic and functional evidence of the existence of a brain renin-angiotensin system and of its interaction with other putative neurotransmitters and their receptors. All components of the RAS have been observed in the striatum, and Ang II modulates dopamine release from striatal dopaminergic terminals, in vivo and in vitro, via their AT1 receptors. There is considerable evidence supporting a key role for dopamine (DA) neurotransmission in the Cpu in long-term neuroadaptative changes induced by stress or psychostimulants, such as cocaine or amphetamine. Repeated amphetamine or cocaine administration results in progressive and enduring enhancement of their psychomotor and positive reinforcing effects (sensitization phenomenon). We recently found evidence of the participation of Ang II, through its AT1 receptors, in the development of the locomotor sensitization induced by psychostimulant drugs. Moreover, the brain RAS may play a role in the pathogenesis and progression of Parkinson?s disease and aging-related loss of DA neurons. Manipulation of RAS components may be useful for neuroprotection in Parkinson?s disease patients because local RAS plays a major role in proinflammatory and pro-oxidative changes in aged substantia nigra. RAS is involved in modulating neurotransmission systems in the CPu and their functions, and for this reason it could be a possible target in the treatment of stress related diseases, drug abuse or neurodegenerative disorders.http://www.novapublishers.com/catalog/product_info.Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.Fil: Marinzalda, M. A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacología; Argentina.Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacologia; Argentina.Fil: Paz, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.Fil: Paz, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaNeurociencias (incluye Psicofiosiología)2014info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_3248info:ar-repo/semantics/parteDeLibroapplication/pdf978-1-61942-188-2http://hdl.handle.net/11086/29950enghttp://hdl.handle.net/11086/20502info:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:43:00Zoai:rdu.unc.edu.ar:11086/29950Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:43:01.026Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Renin-angiotensin sistem modulating funtions in the cpu
title Renin-angiotensin sistem modulating funtions in the cpu
spellingShingle Renin-angiotensin sistem modulating funtions in the cpu
Bregonzio, Claudia
Angiotensin
Brain ras
Caudate putamen
At1 receptors
title_short Renin-angiotensin sistem modulating funtions in the cpu
title_full Renin-angiotensin sistem modulating funtions in the cpu
title_fullStr Renin-angiotensin sistem modulating funtions in the cpu
title_full_unstemmed Renin-angiotensin sistem modulating funtions in the cpu
title_sort Renin-angiotensin sistem modulating funtions in the cpu
dc.creator.none.fl_str_mv Bregonzio, Claudia
Baiardi, Gustavo
Marinzalda, M. A
Paz, María Constanza
author Bregonzio, Claudia
author_facet Bregonzio, Claudia
Baiardi, Gustavo
Marinzalda, M. A
Paz, María Constanza
author_role author
author2 Baiardi, Gustavo
Marinzalda, M. A
Paz, María Constanza
author2_role author
author
author
dc.subject.none.fl_str_mv Angiotensin
Brain ras
Caudate putamen
At1 receptors
topic Angiotensin
Brain ras
Caudate putamen
At1 receptors
dc.description.none.fl_txt_mv Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.
Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Marinzalda, M. A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacología; Argentina.
Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacologia; Argentina.
Fil: Paz, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Paz, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
The caudate-putamen (CPu) of the striatum is one of the main entrances to the basal ganglia. The CPu is fundamentally a dopaminergic area receiving dopamine innervation from the substantia nigra, ventral tegmental area, and mesencephalic structures, but also has noradrenergic inputs from a post-encephalic area, the locus coeruleus, and glutamatergic innervation from cortical structures and cholinergic and GABAergic interneurons. It is well known that functional interactions between different neurotransmission systems play a crucial integrative role in the caudate-putamen, and are widely recognized as contributing to central motor activity and movements, and also to the processing of cognitive and limbic functions, despite autonomic responses across the noradrenergic system. Not only does typical neurotransmission regulate these functions, but peptidergic systems also have an important role. The brain renin-angiotensin system (RAS) is involved not only in the regulation of blood pressure, but also in the modulation of multiple additional functions in the brain, including processes of sensory information, learning and memory, and the regulation of emotional and behavioral responses. There is increasing ontogenetic, anatomic and functional evidence of the existence of a brain renin-angiotensin system and of its interaction with other putative neurotransmitters and their receptors. All components of the RAS have been observed in the striatum, and Ang II modulates dopamine release from striatal dopaminergic terminals, in vivo and in vitro, via their AT1 receptors. There is considerable evidence supporting a key role for dopamine (DA) neurotransmission in the Cpu in long-term neuroadaptative changes induced by stress or psychostimulants, such as cocaine or amphetamine. Repeated amphetamine or cocaine administration results in progressive and enduring enhancement of their psychomotor and positive reinforcing effects (sensitization phenomenon). We recently found evidence of the participation of Ang II, through its AT1 receptors, in the development of the locomotor sensitization induced by psychostimulant drugs. Moreover, the brain RAS may play a role in the pathogenesis and progression of Parkinson?s disease and aging-related loss of DA neurons. Manipulation of RAS components may be useful for neuroprotection in Parkinson?s disease patients because local RAS plays a major role in proinflammatory and pro-oxidative changes in aged substantia nigra. RAS is involved in modulating neurotransmission systems in the CPu and their functions, and for this reason it could be a possible target in the treatment of stress related diseases, drug abuse or neurodegenerative disorders.
http://www.novapublishers.com/catalog/product_info.
Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.
Fil: Bregonzio, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Marinzalda, M. A. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacología; Argentina.
Fil: Baiardi, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.
Fil: Baiardi, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina.
Fil: Baiardi, Gustavo. Universidad Católica de Córdoba. Facultad de Ciencias Químicas. Laboratorio de Neurofarmacologia; Argentina.
Fil: Paz, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Farmacología Experimental de Córdoba; Argentina.
Fil: Paz, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Neurociencias (incluye Psicofiosiología)
description Fil: Bregonzio, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_3248
info:ar-repo/semantics/parteDeLibro
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv 978-1-61942-188-2
http://hdl.handle.net/11086/29950
identifier_str_mv 978-1-61942-188-2
url http://hdl.handle.net/11086/29950
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://hdl.handle.net/11086/20502
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eu_rights_str_mv openAccess
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reponame_str Repositorio Digital Universitario (UNC)
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instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
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