The renin angiotensin system in the central nervous system
- Autores
- Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.
Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; - Materia
-
ANGIOTENSIN
CENTRAL NERVOUS SYSTEM
AT1 RECEPTOR
AT 2 RECEPTOR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/1766
Ver los metadatos del registro completo
id |
CONICETDig_65ef7a1282dac38ea0b75ba00e9d9c22 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/1766 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
The renin angiotensin system in the central nervous systemChoi, Marcelo RobertoCavallero, Carmen SusanaFernandez, Belisario EnriqueANGIOTENSINCENTRAL NERVOUS SYSTEMAT1 RECEPTORAT 2 RECEPTORhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Sociedad Argentina de Fisiología2011-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1766Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-311669-54021669-5410enginfo:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/uploadsarchivos/vol_5___5_2011_the_renin....choi_et_al..pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:39Zoai:ri.conicet.gov.ar:11336/1766instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:39.57CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The renin angiotensin system in the central nervous system |
title |
The renin angiotensin system in the central nervous system |
spellingShingle |
The renin angiotensin system in the central nervous system Choi, Marcelo Roberto ANGIOTENSIN CENTRAL NERVOUS SYSTEM AT1 RECEPTOR AT 2 RECEPTOR |
title_short |
The renin angiotensin system in the central nervous system |
title_full |
The renin angiotensin system in the central nervous system |
title_fullStr |
The renin angiotensin system in the central nervous system |
title_full_unstemmed |
The renin angiotensin system in the central nervous system |
title_sort |
The renin angiotensin system in the central nervous system |
dc.creator.none.fl_str_mv |
Choi, Marcelo Roberto Cavallero, Carmen Susana Fernandez, Belisario Enrique |
author |
Choi, Marcelo Roberto |
author_facet |
Choi, Marcelo Roberto Cavallero, Carmen Susana Fernandez, Belisario Enrique |
author_role |
author |
author2 |
Cavallero, Carmen Susana Fernandez, Belisario Enrique |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ANGIOTENSIN CENTRAL NERVOUS SYSTEM AT1 RECEPTOR AT 2 RECEPTOR |
topic |
ANGIOTENSIN CENTRAL NERVOUS SYSTEM AT1 RECEPTOR AT 2 RECEPTOR |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory. Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina; |
description |
The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/1766 Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-31 1669-5402 1669-5410 |
url |
http://hdl.handle.net/11336/1766 |
identifier_str_mv |
Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-31 1669-5402 1669-5410 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/uploadsarchivos/vol_5___5_2011_the_renin....choi_et_al..pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedad Argentina de Fisiología |
publisher.none.fl_str_mv |
Sociedad Argentina de Fisiología |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269358123909120 |
score |
13.13397 |