The renin angiotensin system in the central nervous system

Autores
Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.
Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Materia
ANGIOTENSIN
CENTRAL NERVOUS SYSTEM
AT1 RECEPTOR
AT 2 RECEPTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1766

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spelling The renin angiotensin system in the central nervous systemChoi, Marcelo RobertoCavallero, Carmen SusanaFernandez, Belisario EnriqueANGIOTENSINCENTRAL NERVOUS SYSTEMAT1 RECEPTORAT 2 RECEPTORhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;Sociedad Argentina de Fisiología2011-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1766Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-311669-54021669-5410enginfo:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/uploadsarchivos/vol_5___5_2011_the_renin....choi_et_al..pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:39Zoai:ri.conicet.gov.ar:11336/1766instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:39.57CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The renin angiotensin system in the central nervous system
title The renin angiotensin system in the central nervous system
spellingShingle The renin angiotensin system in the central nervous system
Choi, Marcelo Roberto
ANGIOTENSIN
CENTRAL NERVOUS SYSTEM
AT1 RECEPTOR
AT 2 RECEPTOR
title_short The renin angiotensin system in the central nervous system
title_full The renin angiotensin system in the central nervous system
title_fullStr The renin angiotensin system in the central nervous system
title_full_unstemmed The renin angiotensin system in the central nervous system
title_sort The renin angiotensin system in the central nervous system
dc.creator.none.fl_str_mv Choi, Marcelo Roberto
Cavallero, Carmen Susana
Fernandez, Belisario Enrique
author Choi, Marcelo Roberto
author_facet Choi, Marcelo Roberto
Cavallero, Carmen Susana
Fernandez, Belisario Enrique
author_role author
author2 Cavallero, Carmen Susana
Fernandez, Belisario Enrique
author2_role author
author
dc.subject.none.fl_str_mv ANGIOTENSIN
CENTRAL NERVOUS SYSTEM
AT1 RECEPTOR
AT 2 RECEPTOR
topic ANGIOTENSIN
CENTRAL NERVOUS SYSTEM
AT1 RECEPTOR
AT 2 RECEPTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.
Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
description The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.
publishDate 2011
dc.date.none.fl_str_mv 2011-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1766
Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-31
1669-5402
1669-5410
url http://hdl.handle.net/11336/1766
identifier_str_mv Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-31
1669-5402
1669-5410
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Fisiología
publisher.none.fl_str_mv Sociedad Argentina de Fisiología
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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