Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones

Autores
Morelatto, R.; Itoiz, M.E.; Guiñazú, N.; Piccini, D.; Gea, S.; López de Blanc, S.
Año de publicación
2014
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
publishedVersion
Materia
Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/4918
Acceder
id RDUUNC_9a266bddc0c087fdae7a6f398c251aab
oai_identifier_str oai:rdu.unc.edu.ar:11086/4918
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblacionesMorelatto, R.Itoiz, M.E.Guiñazú, N.Piccini, D.Gea, S.López de Blanc, S.Field cancerizationOral squamous cell carcinomaNitric Oxide Synthase 2 (NOS2)Malignity markersThe activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.publishedVersionMedicina Oral, Patología Oral y Cirugía Bucal.2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfMorelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-71698-6946http://hdl.handle.net/11086/4918spainfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-16T09:29:24Zoai:rdu.unc.edu.ar:11086/4918Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-16 09:29:25.128Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
title Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
spellingShingle Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
Morelatto, R.
Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
title_short Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
title_full Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
title_fullStr Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
title_full_unstemmed Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
title_sort Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones
dc.creator.none.fl_str_mv Morelatto, R.
Itoiz, M.E.
Guiñazú, N.
Piccini, D.
Gea, S.
López de Blanc, S.
author Morelatto, R.
author_facet Morelatto, R.
Itoiz, M.E.
Guiñazú, N.
Piccini, D.
Gea, S.
López de Blanc, S.
author_role author
author2 Itoiz, M.E.
Guiñazú, N.
Piccini, D.
Gea, S.
López de Blanc, S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
topic Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
dc.description.none.fl_txt_mv The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
publishedVersion
description The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Morelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-7
1698-6946
http://hdl.handle.net/11086/4918
identifier_str_mv Morelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-7
1698-6946
url http://hdl.handle.net/11086/4918
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Medicina Oral, Patología Oral y Cirugía Bucal.
publisher.none.fl_str_mv Medicina Oral, Patología Oral y Cirugía Bucal.
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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score 12.711113

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