Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

Autores
Morelatto, Rosana; Itoiz, María-Elina; Guiñazu, Natalia; Piccini, Daniel; Gea, Susana; López de Blanc, Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina.
Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.
Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
publishedVersion
Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina.
Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.
Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
Materia
Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
Cancerización de campo
Carcinoma oral de células escamosas
Marcadores de malignidad
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/15649
Acceder
id RDUUNC_3b9e63b27d0ad2dcd0259bf5962ed51d
oai_identifier_str oai:rdu.unc.edu.ar:11086/15649
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinomaMorelatto, RosanaItoiz, María-ElinaGuiñazu, NataliaPiccini, DanielGea, SusanaLópez de Blanc, SilviaField cancerizationOral squamous cell carcinomaNitric Oxide Synthase 2 (NOS2)Malignity markersCancerización de campoCarcinoma oral de células escamosasMarcadores de malignidadMorelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina.Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.publishedVersionMorelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina.Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.Acta Odontológica Latinoamericana2014-05-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfMorelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-7.1698-4447http://dx.doi.org/doi:10.4317/medoral.19351http://hdl.handle.net/11086/15649enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:43:29Zoai:rdu.unc.edu.ar:11086/15649Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:43:29.492Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
spellingShingle Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
Morelatto, Rosana
Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
Cancerización de campo
Carcinoma oral de células escamosas
Marcadores de malignidad
title_short Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_full Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_fullStr Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_full_unstemmed Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
title_sort Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma
dc.creator.none.fl_str_mv Morelatto, Rosana
Itoiz, María-Elina
Guiñazu, Natalia
Piccini, Daniel
Gea, Susana
López de Blanc, Silvia
author Morelatto, Rosana
author_facet Morelatto, Rosana
Itoiz, María-Elina
Guiñazu, Natalia
Piccini, Daniel
Gea, Susana
López de Blanc, Silvia
author_role author
author2 Itoiz, María-Elina
Guiñazu, Natalia
Piccini, Daniel
Gea, Susana
López de Blanc, Silvia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
Cancerización de campo
Carcinoma oral de células escamosas
Marcadores de malignidad
topic Field cancerization
Oral squamous cell carcinoma
Nitric Oxide Synthase 2 (NOS2)
Malignity markers
Cancerización de campo
Carcinoma oral de células escamosas
Marcadores de malignidad
dc.description.none.fl_txt_mv Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina.
Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.
Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
publishedVersion
Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
Itoiz, María-Elina. Universidad de Buenos Aires. Facultad de Odontología; Argentina.
Guiñazu, Natalia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
Piccini, Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina.
Gea, Susana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica; Argentina.
López de Blanc, Silvia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
description Morelatto, Rosana. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología; Argentina.
publishDate 2014
dc.date.none.fl_str_mv 2014-05-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Morelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-7.
1698-4447
http://dx.doi.org/doi:10.4317/medoral.19351
http://hdl.handle.net/11086/15649
identifier_str_mv Morelatto R, Itoiz ME, Guiñazú N, Piccini D, Gea S, López-de Blanc S. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal. 2014 May 1;19 (3):e242-7.
1698-4447
url http://dx.doi.org/doi:10.4317/medoral.19351
http://hdl.handle.net/11086/15649
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Acta Odontológica Latinoamericana
publisher.none.fl_str_mv Acta Odontológica Latinoamericana
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
_version_ 1844618957332414464
score 13.260194

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