Generation and characterization of novel magnetic field-responsive biomaterials.
- Autores
- López López, M.T.; Scionti, G.; Oliveira, A.C.; G. Durán, J.D.; Campos, A.; Alaminos, M.; Rodríguez, I.A.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.
publishedVersion - Materia
-
Biocompatible materials
Family characteristics
Characterization - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/4931
Ver los metadatos del registro completo
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RDUUNC |
repository_id_str |
2572 |
network_name_str |
Repositorio Digital Universitario (UNC) |
spelling |
Generation and characterization of novel magnetic field-responsive biomaterials.López López, M.T.Scionti, G.Oliveira, A.C.G. Durán, J.D.Campos, A.Alaminos, M.Rodríguez, I.A.Biocompatible materialsFamily characteristicsCharacterizationWe report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.publishedVersionPloS One.2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfLopez-lopez, M.T, Scionti, G, Oliveira, A.C, Duran, J.D.G, Campos, A., Rodríguez, I.A. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PloS One. 2015;10(7): 1-17.1932-6203http://hdl.handle.net/11086/4931enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:44:40Zoai:rdu.unc.edu.ar:11086/4931Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:44:41.111Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
dc.title.none.fl_str_mv |
Generation and characterization of novel magnetic field-responsive biomaterials. |
title |
Generation and characterization of novel magnetic field-responsive biomaterials. |
spellingShingle |
Generation and characterization of novel magnetic field-responsive biomaterials. López López, M.T. Biocompatible materials Family characteristics Characterization |
title_short |
Generation and characterization of novel magnetic field-responsive biomaterials. |
title_full |
Generation and characterization of novel magnetic field-responsive biomaterials. |
title_fullStr |
Generation and characterization of novel magnetic field-responsive biomaterials. |
title_full_unstemmed |
Generation and characterization of novel magnetic field-responsive biomaterials. |
title_sort |
Generation and characterization of novel magnetic field-responsive biomaterials. |
dc.creator.none.fl_str_mv |
López López, M.T. Scionti, G. Oliveira, A.C. G. Durán, J.D. Campos, A. Alaminos, M. Rodríguez, I.A. |
author |
López López, M.T. |
author_facet |
López López, M.T. Scionti, G. Oliveira, A.C. G. Durán, J.D. Campos, A. Alaminos, M. Rodríguez, I.A. |
author_role |
author |
author2 |
Scionti, G. Oliveira, A.C. G. Durán, J.D. Campos, A. Alaminos, M. Rodríguez, I.A. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Biocompatible materials Family characteristics Characterization |
topic |
Biocompatible materials Family characteristics Characterization |
dc.description.none.fl_txt_mv |
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications. publishedVersion |
description |
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
Lopez-lopez, M.T, Scionti, G, Oliveira, A.C, Duran, J.D.G, Campos, A., Rodríguez, I.A. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PloS One. 2015;10(7): 1-17. 1932-6203 http://hdl.handle.net/11086/4931 |
identifier_str_mv |
Lopez-lopez, M.T, Scionti, G, Oliveira, A.C, Duran, J.D.G, Campos, A., Rodríguez, I.A. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PloS One. 2015;10(7): 1-17. 1932-6203 |
url |
http://hdl.handle.net/11086/4931 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
PloS One. |
publisher.none.fl_str_mv |
PloS One. |
dc.source.none.fl_str_mv |
reponame:Repositorio Digital Universitario (UNC) instname:Universidad Nacional de Córdoba instacron:UNC |
reponame_str |
Repositorio Digital Universitario (UNC) |
collection |
Repositorio Digital Universitario (UNC) |
instname_str |
Universidad Nacional de Córdoba |
instacron_str |
UNC |
institution |
UNC |
repository.name.fl_str_mv |
Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba |
repository.mail.fl_str_mv |
oca.unc@gmail.com |
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1844618988852609024 |
score |
13.070432 |