Generation and characterization of novel magnetic field-responsive biomaterials.

Autores
López López, M.T.; Scionti, G.; Oliveira, A.C.; G. Durán, J.D.; Campos, A.; Alaminos, M.; Rodríguez, I.A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.
publishedVersion
Materia
Biocompatible materials
Family characteristics
Characterization
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/4931

id RDUUNC_9821046b835ce9d73335f87aa7a70bb9
oai_identifier_str oai:rdu.unc.edu.ar:11086/4931
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Generation and characterization of novel magnetic field-responsive biomaterials.López López, M.T.Scionti, G.Oliveira, A.C.G. Durán, J.D.Campos, A.Alaminos, M.Rodríguez, I.A.Biocompatible materialsFamily characteristicsCharacterizationWe report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.publishedVersionPloS One.2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfLopez-lopez, M.T, Scionti, G, Oliveira, A.C, Duran, J.D.G, Campos, A., Rodríguez, I.A. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PloS One. 2015;10(7): 1-17.1932-6203http://hdl.handle.net/11086/4931enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:44:40Zoai:rdu.unc.edu.ar:11086/4931Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:44:41.111Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Generation and characterization of novel magnetic field-responsive biomaterials.
title Generation and characterization of novel magnetic field-responsive biomaterials.
spellingShingle Generation and characterization of novel magnetic field-responsive biomaterials.
López López, M.T.
Biocompatible materials
Family characteristics
Characterization
title_short Generation and characterization of novel magnetic field-responsive biomaterials.
title_full Generation and characterization of novel magnetic field-responsive biomaterials.
title_fullStr Generation and characterization of novel magnetic field-responsive biomaterials.
title_full_unstemmed Generation and characterization of novel magnetic field-responsive biomaterials.
title_sort Generation and characterization of novel magnetic field-responsive biomaterials.
dc.creator.none.fl_str_mv López López, M.T.
Scionti, G.
Oliveira, A.C.
G. Durán, J.D.
Campos, A.
Alaminos, M.
Rodríguez, I.A.
author López López, M.T.
author_facet López López, M.T.
Scionti, G.
Oliveira, A.C.
G. Durán, J.D.
Campos, A.
Alaminos, M.
Rodríguez, I.A.
author_role author
author2 Scionti, G.
Oliveira, A.C.
G. Durán, J.D.
Campos, A.
Alaminos, M.
Rodríguez, I.A.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Biocompatible materials
Family characteristics
Characterization
topic Biocompatible materials
Family characteristics
Characterization
dc.description.none.fl_txt_mv We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.
publishedVersion
description We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Lopez-lopez, M.T, Scionti, G, Oliveira, A.C, Duran, J.D.G, Campos, A., Rodríguez, I.A. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PloS One. 2015;10(7): 1-17.
1932-6203
http://hdl.handle.net/11086/4931
identifier_str_mv Lopez-lopez, M.T, Scionti, G, Oliveira, A.C, Duran, J.D.G, Campos, A., Rodríguez, I.A. Generation and Characterization of Novel Magnetic Field-Responsive Biomaterials. PloS One. 2015;10(7): 1-17.
1932-6203
url http://hdl.handle.net/11086/4931
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv PloS One.
publisher.none.fl_str_mv PloS One.
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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score 13.070432