Bisphosphonates study on effect of implant-bone interface

Autores
Brunengo, Ignacio; Virga, María Carolina; Aguzzi, Alejandra; Sosa, Federico; Marion, Gustavo Carlos
Año de publicación
2014
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.
Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina.
Introduction: The success of any dental implant depends on a number of parameters including general health conditions, biocompatibility of implant materials, the nature of the surface of the microscopic and macroscopic implant, the surgical procedure and the quality and quantity of bone maxilla. Objective: to evaluate the alkaline phosphatase (AP) levels to analyze the therapeutic response to treatment with bisphosphonates administered subcutaneously in experimental animals. Materials and Methods: The pharmaceutical formulations were prepared with a dosage for Alendronate (AL) of 0.5 mg / kg weight, and pamidronate (PA) of 0.6 mg / Kg . Control (C) was saline. The effect was evaluated in normal male Wistar rats, which were divided into three groups, one control and two problems. We designed a class IV titanium microimplant dimensions 1 mm diameter by 2 mm to place in rat tibia after a drilling operation with strawberry No.6 manual rotation. AP in blood was measured to analyze bone level changes. Comparison of the data was performed by analysis of variance of two criteria (treatments and treatment times: 0, 15, 30, 60 and 90 days). Differences were considered significant if p <0.05. Results: The average value obtained in pubertal rats was 1425 IU / I, and in normal adult rats taken as a parameter for estimating the bone marker normal values in rats was 51.03 IU / l. The data showed that the experimental groups at 15 days 1.37 higher PA than AL; 30 days PA is 1.12 higher than Al, at 60 days 1, 14 and 90 days increased 1.07 higher. Conclusions: The experimental model healthy male rats subcutaneously weekly treatment with AL and PA for 12 weeks resulted in significant variations in mineral concentrations in blood, revealing an inhibitory action on osteoclast activity by the drugs studied .
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.
Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina.
Otras Ciencias Médicas
Materia
Implantación dental
Implantes dentales
Alendronato
Difosfonatos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/21622

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network_name_str Repositorio Digital Universitario (UNC)
spelling Bisphosphonates study on effect of implant-bone interfaceBrunengo, IgnacioVirga, María CarolinaAguzzi, AlejandraSosa, FedericoMarion, Gustavo CarlosImplantación dentalImplantes dentalesAlendronatoDifosfonatosFil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina.Introduction: The success of any dental implant depends on a number of parameters including general health conditions, biocompatibility of implant materials, the nature of the surface of the microscopic and macroscopic implant, the surgical procedure and the quality and quantity of bone maxilla. Objective: to evaluate the alkaline phosphatase (AP) levels to analyze the therapeutic response to treatment with bisphosphonates administered subcutaneously in experimental animals. Materials and Methods: The pharmaceutical formulations were prepared with a dosage for Alendronate (AL) of 0.5 mg / kg weight, and pamidronate (PA) of 0.6 mg / Kg . Control (C) was saline. The effect was evaluated in normal male Wistar rats, which were divided into three groups, one control and two problems. We designed a class IV titanium microimplant dimensions 1 mm diameter by 2 mm to place in rat tibia after a drilling operation with strawberry No.6 manual rotation. AP in blood was measured to analyze bone level changes. Comparison of the data was performed by analysis of variance of two criteria (treatments and treatment times: 0, 15, 30, 60 and 90 days). Differences were considered significant if p <0.05. Results: The average value obtained in pubertal rats was 1425 IU / I, and in normal adult rats taken as a parameter for estimating the bone marker normal values in rats was 51.03 IU / l. The data showed that the experimental groups at 15 days 1.37 higher PA than AL; 30 days PA is 1.12 higher than Al, at 60 days 1, 14 and 90 days increased 1.07 higher. Conclusions: The experimental model healthy male rats subcutaneously weekly treatment with AL and PA for 12 weeks resulted in significant variations in mineral concentrations in blood, revealing an inhibitory action on osteoclast activity by the drugs studied .Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina.Otras Ciencias Médicas2014info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/21622enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:42:44Zoai:rdu.unc.edu.ar:11086/21622Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:42:44.495Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Bisphosphonates study on effect of implant-bone interface
title Bisphosphonates study on effect of implant-bone interface
spellingShingle Bisphosphonates study on effect of implant-bone interface
Brunengo, Ignacio
Implantación dental
Implantes dentales
Alendronato
Difosfonatos
title_short Bisphosphonates study on effect of implant-bone interface
title_full Bisphosphonates study on effect of implant-bone interface
title_fullStr Bisphosphonates study on effect of implant-bone interface
title_full_unstemmed Bisphosphonates study on effect of implant-bone interface
title_sort Bisphosphonates study on effect of implant-bone interface
dc.creator.none.fl_str_mv Brunengo, Ignacio
Virga, María Carolina
Aguzzi, Alejandra
Sosa, Federico
Marion, Gustavo Carlos
author Brunengo, Ignacio
author_facet Brunengo, Ignacio
Virga, María Carolina
Aguzzi, Alejandra
Sosa, Federico
Marion, Gustavo Carlos
author_role author
author2 Virga, María Carolina
Aguzzi, Alejandra
Sosa, Federico
Marion, Gustavo Carlos
author2_role author
author
author
author
dc.subject.none.fl_str_mv Implantación dental
Implantes dentales
Alendronato
Difosfonatos
topic Implantación dental
Implantes dentales
Alendronato
Difosfonatos
dc.description.none.fl_txt_mv Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.
Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina.
Introduction: The success of any dental implant depends on a number of parameters including general health conditions, biocompatibility of implant materials, the nature of the surface of the microscopic and macroscopic implant, the surgical procedure and the quality and quantity of bone maxilla. Objective: to evaluate the alkaline phosphatase (AP) levels to analyze the therapeutic response to treatment with bisphosphonates administered subcutaneously in experimental animals. Materials and Methods: The pharmaceutical formulations were prepared with a dosage for Alendronate (AL) of 0.5 mg / kg weight, and pamidronate (PA) of 0.6 mg / Kg . Control (C) was saline. The effect was evaluated in normal male Wistar rats, which were divided into three groups, one control and two problems. We designed a class IV titanium microimplant dimensions 1 mm diameter by 2 mm to place in rat tibia after a drilling operation with strawberry No.6 manual rotation. AP in blood was measured to analyze bone level changes. Comparison of the data was performed by analysis of variance of two criteria (treatments and treatment times: 0, 15, 30, 60 and 90 days). Differences were considered significant if p <0.05. Results: The average value obtained in pubertal rats was 1425 IU / I, and in normal adult rats taken as a parameter for estimating the bone marker normal values in rats was 51.03 IU / l. The data showed that the experimental groups at 15 days 1.37 higher PA than AL; 30 days PA is 1.12 higher than Al, at 60 days 1, 14 and 90 days increased 1.07 higher. Conclusions: The experimental model healthy male rats subcutaneously weekly treatment with AL and PA for 12 weeks resulted in significant variations in mineral concentrations in blood, revealing an inhibitory action on osteoclast activity by the drugs studied .
Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Virga, María Carolina. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica B; Argentina.
Fil: Aguzzi, Alejandra. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Farmacología y Terapéutica A; Argentina.
Fil: Sosa, Federico. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
Fil: Marion, Gustavo Carlos. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Prostodoncia III A; Argentina.
Otras Ciencias Médicas
description Fil: Brunengo, Ignacio. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina.
publishDate 2014
dc.date.none.fl_str_mv 2014
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info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv http://hdl.handle.net/11086/21622
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language eng
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