Sex chromosome complement influences communicative behavior in the valproic acid animal model of autism spectrum disorder

• Autores: Cravero, Lucio; Cambiasso, María Julia
• Año de publicación: 2020
• Idioma: inglés
• Tipo de recurso: documento de conferencia
• Materia: Autism; Gonadal sex; Sex chromosome complement
• Institución: Universidad Nacional de Córdoba

Fil: Cravero, Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Medicas Mercedes y Martín Ferreyra; Argentina.
Fil: Cambiasso, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular B; Argentina.
Fil: Cambiasso, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.
Autism spectrum disorder (ASD) is a group of neurodevelopmental pathologies characterized by persistent deficits in social communication, restricted interest and repetitive behaviours. Given the strong impact of sex on ASD prevalence (4:1 male-to-female ratio), we wonder if the sex chromosome complement modulates the communicative behavior in a valproic acid (VPA)-induced ASD related phenotype in mice. To this end, we used the ?four core genotypes? (FCG) mouse model, in which the effect of gonadal sex and sex chromosome complement is dissociated, to determine if sex chromosomes influence the pup ultrasonic vocalizations (USV) induced by maternal-separation. Pregnant mice of the FCG received a single intraperitoneal injection of VPA (500 mg/kg) on gestational day 12.5. During the early postnatal development (PN6-PN12), the USV were recorded in the sound-attenuating chambers for 4 min using a vocalization detector. The total number of USVs emitted in the range 45-100 kHz were analysed by Kruscal Wallis test. The results demonstrated that USVs decreased with development in all groups (p<0.05). At PN12, only XY female mice prenatally exposed -VPA showed fewer vocalization than control (p<0.05), whereas VPA-treated XY male produced more USVs than VPA-treated XX male pups (p<0.05). These results suggest a complex interaction between the genetic background derived from sex chromosomes and the gonadal phenotype that should be explored to contribute to the understanding of ASD.
http://www.saneurociencias.org.ar/programa-2019/
Fil: Cravero, Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias Medicas Mercedes y Martín Ferreyra; Argentina.
Fil: Cambiasso, María Julia. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Biología Celular B; Argentina.
Fil: Cambiasso, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.
Neurociencias (incluye Psicofiosiología)