Hormonal and genetic factors interact to control aromatase expression in the developing brain

Autores
Cisternas, Carla Daniela; Garcia Segura, Luis Miguel; Cambiasso, Maria Julia
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Brain expression of the enzyme P450-aromatase has been studied extensively. Subsequent to the aromatisation hypothesis having established brain aromatase as a key factor to convert gonadal testosterone to oestradiol, several studies have investigated the regulation of aromatase during the critical period of brain sexual differentiation. We review previous and recent findings concerning regulation of aromatase. The role of gonadal hormones, sex chromosome genes and neurosteroids is analysed in terms of their contribution to aromatase expression, as well as implications for the organisational effect of steroids during development.
Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Garcia Segura, Luis Miguel. INSTITUTO CAJAL ; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Materia
AMYGDALA
AROMATASE
GONADAL HORMONES
SEX CHROMOSOME COMPLEMENT
SEX DIFFERENCES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/186044
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Hormonal and genetic factors interact to control aromatase expression in the developing brainCisternas, Carla DanielaGarcia Segura, Luis MiguelCambiasso, Maria JuliaAMYGDALAAROMATASEGONADAL HORMONESSEX CHROMOSOME COMPLEMENTSEX DIFFERENCEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Brain expression of the enzyme P450-aromatase has been studied extensively. Subsequent to the aromatisation hypothesis having established brain aromatase as a key factor to convert gonadal testosterone to oestradiol, several studies have investigated the regulation of aromatase during the critical period of brain sexual differentiation. We review previous and recent findings concerning regulation of aromatase. The role of gonadal hormones, sex chromosome genes and neurosteroids is analysed in terms of their contribution to aromatase expression, as well as implications for the organisational effect of steroids during development.Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaFil: Garcia Segura, Luis Miguel. INSTITUTO CAJAL ; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; ArgentinaWiley Blackwell Publishing, Inc2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/186044Cisternas, Carla Daniela; Garcia Segura, Luis Miguel; Cambiasso, Maria Julia; Hormonal and genetic factors interact to control aromatase expression in the developing brain; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 2; 2-2018; 1-80953-8194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/jne.12535info:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12535info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:38Zoai:ri.conicet.gov.ar:11336/186044instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:38.805CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hormonal and genetic factors interact to control aromatase expression in the developing brain
title Hormonal and genetic factors interact to control aromatase expression in the developing brain
spellingShingle Hormonal and genetic factors interact to control aromatase expression in the developing brain
Cisternas, Carla Daniela
AMYGDALA
AROMATASE
GONADAL HORMONES
SEX CHROMOSOME COMPLEMENT
SEX DIFFERENCES
title_short Hormonal and genetic factors interact to control aromatase expression in the developing brain
title_full Hormonal and genetic factors interact to control aromatase expression in the developing brain
title_fullStr Hormonal and genetic factors interact to control aromatase expression in the developing brain
title_full_unstemmed Hormonal and genetic factors interact to control aromatase expression in the developing brain
title_sort Hormonal and genetic factors interact to control aromatase expression in the developing brain
dc.creator.none.fl_str_mv Cisternas, Carla Daniela
Garcia Segura, Luis Miguel
Cambiasso, Maria Julia
author Cisternas, Carla Daniela
author_facet Cisternas, Carla Daniela
Garcia Segura, Luis Miguel
Cambiasso, Maria Julia
author_role author
author2 Garcia Segura, Luis Miguel
Cambiasso, Maria Julia
author2_role author
author
dc.subject.none.fl_str_mv AMYGDALA
AROMATASE
GONADAL HORMONES
SEX CHROMOSOME COMPLEMENT
SEX DIFFERENCES
topic AMYGDALA
AROMATASE
GONADAL HORMONES
SEX CHROMOSOME COMPLEMENT
SEX DIFFERENCES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Brain expression of the enzyme P450-aromatase has been studied extensively. Subsequent to the aromatisation hypothesis having established brain aromatase as a key factor to convert gonadal testosterone to oestradiol, several studies have investigated the regulation of aromatase during the critical period of brain sexual differentiation. We review previous and recent findings concerning regulation of aromatase. The role of gonadal hormones, sex chromosome genes and neurosteroids is analysed in terms of their contribution to aromatase expression, as well as implications for the organisational effect of steroids during development.
Fil: Cisternas, Carla Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
Fil: Garcia Segura, Luis Miguel. INSTITUTO CAJAL ; CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS;
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina
description Brain expression of the enzyme P450-aromatase has been studied extensively. Subsequent to the aromatisation hypothesis having established brain aromatase as a key factor to convert gonadal testosterone to oestradiol, several studies have investigated the regulation of aromatase during the critical period of brain sexual differentiation. We review previous and recent findings concerning regulation of aromatase. The role of gonadal hormones, sex chromosome genes and neurosteroids is analysed in terms of their contribution to aromatase expression, as well as implications for the organisational effect of steroids during development.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/186044
Cisternas, Carla Daniela; Garcia Segura, Luis Miguel; Cambiasso, Maria Julia; Hormonal and genetic factors interact to control aromatase expression in the developing brain; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 2; 2-2018; 1-8
0953-8194
CONICET Digital
CONICET
url http://hdl.handle.net/11336/186044
identifier_str_mv Cisternas, Carla Daniela; Garcia Segura, Luis Miguel; Cambiasso, Maria Julia; Hormonal and genetic factors interact to control aromatase expression in the developing brain; Wiley Blackwell Publishing, Inc; Journal of Neuroendocrinology; 30; 2; 2-2018; 1-8
0953-8194
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1111/jne.12535
info:eu-repo/semantics/altIdentifier/doi/10.1111/jne.12535
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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