Sex chromosome complement contributes to sex differences in bradycardic baroreflex response

Autores
Caeiro, X. E.; Mir, F. R.; Vivas, L. M.; Carrer, H. F.; Cambiasso, M. J.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II– bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX and XY females, as well as in XX and XY males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1 mg/mL), angiotensin II (100g/mL), and sodium nitroprusside (1 mg/mL). The administration of phenylephrine in GDX-XY females resulted in a significantly lower baroreflex response when compared with the other genotypes (in beats min 1mm Hg1 [slopes of regression lines for GDX-XY females 3.560.37 versus 6.060.38, 6.370.54 and 6.700.34 for GDX-XY male, GDX-XX female, and GDX-XX male mice, respectively]) {F(1,19)9.63; P0.01}. In addition, in both GDX-XY males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared with heart rate changes in GDX-XX male and female mice (in beats min1 mm Hg1 [slopes of regression lines: 2.830.28 versus 5.760.26 in GDX-XY and GDX-XX mice, respectively]) {F(1,19)13.91; P0.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all of the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.
publishedVersion
Materia
Bradycardic baroreflex response
Sex chromosome complement
Ang II
Phenylephrine
Sex characteristics
Four core genotype
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Repositorio Digital Universitario (UNC)
Institución
Universidad Nacional de Córdoba
OAI Identificador
oai:rdu.unc.edu.ar:11086/4904

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oai_identifier_str oai:rdu.unc.edu.ar:11086/4904
network_acronym_str RDUUNC
repository_id_str 2572
network_name_str Repositorio Digital Universitario (UNC)
spelling Sex chromosome complement contributes to sex differences in bradycardic baroreflex responseCaeiro, X. E.Mir, F. R.Vivas, L. M.Carrer, H. F.Cambiasso, M. J.Bradycardic baroreflex responseSex chromosome complementAng IIPhenylephrineSex characteristicsFour core genotypeTo investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II– bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX and XY females, as well as in XX and XY males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1 mg/mL), angiotensin II (100g/mL), and sodium nitroprusside (1 mg/mL). The administration of phenylephrine in GDX-XY females resulted in a significantly lower baroreflex response when compared with the other genotypes (in beats min 1mm Hg1 [slopes of regression lines for GDX-XY females 3.560.37 versus 6.060.38, 6.370.54 and 6.700.34 for GDX-XY male, GDX-XX female, and GDX-XX male mice, respectively]) {F(1,19)9.63; P0.01}. In addition, in both GDX-XY males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared with heart rate changes in GDX-XX male and female mice (in beats min1 mm Hg1 [slopes of regression lines: 2.830.28 versus 5.760.26 in GDX-XY and GDX-XX mice, respectively]) {F(1,19)13.91; P0.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all of the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.publishedVersionHypertension2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfCaeiro, X. E, Mir, F. R, Vivas, L. M, Carrer, H. F, Cambiasso, M. J. Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response. Hypertension. 2011;58(3): 505-511.1524-4563http://hdl.handle.net/11086/4904enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-09-29T13:44:20Zoai:rdu.unc.edu.ar:11086/4904Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-09-29 13:44:20.972Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse
dc.title.none.fl_str_mv Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
title Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
spellingShingle Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
Caeiro, X. E.
Bradycardic baroreflex response
Sex chromosome complement
Ang II
Phenylephrine
Sex characteristics
Four core genotype
title_short Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
title_full Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
title_fullStr Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
title_full_unstemmed Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
title_sort Sex chromosome complement contributes to sex differences in bradycardic baroreflex response
dc.creator.none.fl_str_mv Caeiro, X. E.
Mir, F. R.
Vivas, L. M.
Carrer, H. F.
Cambiasso, M. J.
author Caeiro, X. E.
author_facet Caeiro, X. E.
Mir, F. R.
Vivas, L. M.
Carrer, H. F.
Cambiasso, M. J.
author_role author
author2 Mir, F. R.
Vivas, L. M.
Carrer, H. F.
Cambiasso, M. J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bradycardic baroreflex response
Sex chromosome complement
Ang II
Phenylephrine
Sex characteristics
Four core genotype
topic Bradycardic baroreflex response
Sex chromosome complement
Ang II
Phenylephrine
Sex characteristics
Four core genotype
dc.description.none.fl_txt_mv To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II– bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX and XY females, as well as in XX and XY males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1 mg/mL), angiotensin II (100g/mL), and sodium nitroprusside (1 mg/mL). The administration of phenylephrine in GDX-XY females resulted in a significantly lower baroreflex response when compared with the other genotypes (in beats min 1mm Hg1 [slopes of regression lines for GDX-XY females 3.560.37 versus 6.060.38, 6.370.54 and 6.700.34 for GDX-XY male, GDX-XX female, and GDX-XX male mice, respectively]) {F(1,19)9.63; P0.01}. In addition, in both GDX-XY males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared with heart rate changes in GDX-XX male and female mice (in beats min1 mm Hg1 [slopes of regression lines: 2.830.28 versus 5.760.26 in GDX-XY and GDX-XX mice, respectively]) {F(1,19)13.91; P0.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all of the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.
publishedVersion
description To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II– bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX and XY females, as well as in XX and XY males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1 mg/mL), angiotensin II (100g/mL), and sodium nitroprusside (1 mg/mL). The administration of phenylephrine in GDX-XY females resulted in a significantly lower baroreflex response when compared with the other genotypes (in beats min 1mm Hg1 [slopes of regression lines for GDX-XY females 3.560.37 versus 6.060.38, 6.370.54 and 6.700.34 for GDX-XY male, GDX-XX female, and GDX-XX male mice, respectively]) {F(1,19)9.63; P0.01}. In addition, in both GDX-XY males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared with heart rate changes in GDX-XX male and female mice (in beats min1 mm Hg1 [slopes of regression lines: 2.830.28 versus 5.760.26 in GDX-XY and GDX-XX mice, respectively]) {F(1,19)13.91; P0.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all of the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv Caeiro, X. E, Mir, F. R, Vivas, L. M, Carrer, H. F, Cambiasso, M. J. Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response. Hypertension. 2011;58(3): 505-511.
1524-4563
http://hdl.handle.net/11086/4904
identifier_str_mv Caeiro, X. E, Mir, F. R, Vivas, L. M, Carrer, H. F, Cambiasso, M. J. Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response. Hypertension. 2011;58(3): 505-511.
1524-4563
url http://hdl.handle.net/11086/4904
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hypertension
publisher.none.fl_str_mv Hypertension
dc.source.none.fl_str_mv reponame:Repositorio Digital Universitario (UNC)
instname:Universidad Nacional de Córdoba
instacron:UNC
reponame_str Repositorio Digital Universitario (UNC)
collection Repositorio Digital Universitario (UNC)
instname_str Universidad Nacional de Córdoba
instacron_str UNC
institution UNC
repository.name.fl_str_mv Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdoba
repository.mail.fl_str_mv oca.unc@gmail.com
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