Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response

Autores
Caeiro, Ximena Elizabeth; Mir, Franco Rafael; Vivas, Laura Marta; Carrer, Hugo Felipe; Cambiasso, Maria Julia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II-bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX- and XY-females as well as in XX- and XY-males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1.0 mg/ml), angiotensin II (100 ìg/ml) and sodium nitroprusside (1 mg/ml). The administration of phenylephrine in GDX-XY-females resulted in a significantly lower baroreflex response when compared to the other genotypes [in beats.min-1.mmHg-1 (slopes of regression lines for GDX-XY-females -3.56 ± 0.37 vs. -6.06 ± 0.38, -6.36 ± 0.54 and -6.70 ± 0.34 for GDX-XY-male, GDX-XX-female and GDX-XX-male mice respectively)] {F(1,19)=9,63; p<0.01}. Besides, in both GDX-XY-males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared to heart rate changes in GDX-XX-male and female mice [in beats.min-1.mmHg-1 slopes of regression lines: -2.83 ± 0.28 vs. -5.76 ± 0.26 in GDX-XY and GDX-XX mice respectively] {F(1,19)=13,91; p<.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.
Fil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Mir, Franco Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Carrer, Hugo Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
Bradycardic baroreflex response
sex chromosome complement
ANG II
phenylephrine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280248
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/280248
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex ResponseCaeiro, Ximena ElizabethMir, Franco RafaelVivas, Laura MartaCarrer, Hugo FelipeCambiasso, Maria JuliaBradycardic baroreflex responsesex chromosome complementANG IIphenylephrinehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II-bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX- and XY-females as well as in XX- and XY-males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1.0 mg/ml), angiotensin II (100 ìg/ml) and sodium nitroprusside (1 mg/ml). The administration of phenylephrine in GDX-XY-females resulted in a significantly lower baroreflex response when compared to the other genotypes [in beats.min-1.mmHg-1 (slopes of regression lines for GDX-XY-females -3.56 ± 0.37 vs. -6.06 ± 0.38, -6.36 ± 0.54 and -6.70 ± 0.34 for GDX-XY-male, GDX-XX-female and GDX-XX-male mice respectively)] {F(1,19)=9,63; p<0.01}. Besides, in both GDX-XY-males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared to heart rate changes in GDX-XX-male and female mice [in beats.min-1.mmHg-1 slopes of regression lines: -2.83 ± 0.28 vs. -5.76 ± 0.26 in GDX-XY and GDX-XX mice respectively] {F(1,19)=13,91; p<.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.Fil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Mir, Franco Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Carrer, Hugo Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaLippincott Williams2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280248Caeiro, Ximena Elizabeth; Mir, Franco Rafael; Vivas, Laura Marta; Carrer, Hugo Felipe; Cambiasso, Maria Julia; Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response; Lippincott Williams; Hypertension; 58; 3; 7-2011; 505-5110194-911XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://hyper.ahajournals.org/content/58/3/505.longinfo:eu-repo/semantics/altIdentifier/doi/10.1161/HYPERTENSIONAHA.111.175661info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T13:18:59Zoai:ri.conicet.gov.ar:11336/280248instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 13:18:59.692CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
title Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
spellingShingle Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
Caeiro, Ximena Elizabeth
Bradycardic baroreflex response
sex chromosome complement
ANG II
phenylephrine
title_short Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
title_full Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
title_fullStr Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
title_full_unstemmed Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
title_sort Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response
dc.creator.none.fl_str_mv Caeiro, Ximena Elizabeth
Mir, Franco Rafael
Vivas, Laura Marta
Carrer, Hugo Felipe
Cambiasso, Maria Julia
author Caeiro, Ximena Elizabeth
author_facet Caeiro, Ximena Elizabeth
Mir, Franco Rafael
Vivas, Laura Marta
Carrer, Hugo Felipe
Cambiasso, Maria Julia
author_role author
author2 Mir, Franco Rafael
Vivas, Laura Marta
Carrer, Hugo Felipe
Cambiasso, Maria Julia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bradycardic baroreflex response
sex chromosome complement
ANG II
phenylephrine
topic Bradycardic baroreflex response
sex chromosome complement
ANG II
phenylephrine
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II-bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX- and XY-females as well as in XX- and XY-males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1.0 mg/ml), angiotensin II (100 ìg/ml) and sodium nitroprusside (1 mg/ml). The administration of phenylephrine in GDX-XY-females resulted in a significantly lower baroreflex response when compared to the other genotypes [in beats.min-1.mmHg-1 (slopes of regression lines for GDX-XY-females -3.56 ± 0.37 vs. -6.06 ± 0.38, -6.36 ± 0.54 and -6.70 ± 0.34 for GDX-XY-male, GDX-XX-female and GDX-XX-male mice respectively)] {F(1,19)=9,63; p<0.01}. Besides, in both GDX-XY-males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared to heart rate changes in GDX-XX-male and female mice [in beats.min-1.mmHg-1 slopes of regression lines: -2.83 ± 0.28 vs. -5.76 ± 0.26 in GDX-XY and GDX-XX mice respectively] {F(1,19)=13,91; p<.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.
Fil: Caeiro, Ximena Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Mir, Franco Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Carrer, Hugo Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Cambiasso, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II-bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX- and XY-females as well as in XX- and XY-males. In conscious gonadectomized (GDX) MF1 transgenic mice we evaluated baroreflex regulation of heart rate in response to changes in blood pressure evoked by phenylephrine (1.0 mg/ml), angiotensin II (100 ìg/ml) and sodium nitroprusside (1 mg/ml). The administration of phenylephrine in GDX-XY-females resulted in a significantly lower baroreflex response when compared to the other genotypes [in beats.min-1.mmHg-1 (slopes of regression lines for GDX-XY-females -3.56 ± 0.37 vs. -6.06 ± 0.38, -6.36 ± 0.54 and -6.70 ± 0.34 for GDX-XY-male, GDX-XX-female and GDX-XX-male mice respectively)] {F(1,19)=9,63; p<0.01}. Besides, in both GDX-XY-males and females, the angiotensin II-bradycardic baroreflex response was attenuated when compared to heart rate changes in GDX-XX-male and female mice [in beats.min-1.mmHg-1 slopes of regression lines: -2.83 ± 0.28 vs. -5.76 ± 0.26 in GDX-XY and GDX-XX mice respectively] {F(1,19)=13,91; p<.005}. In contrast, reflex tachycardic responses to sodium nitroprusside were comparable in all the genotypes. These data support the hypothesis that sex chromosome complement modulates reflex inhibition of heart rate to phenylephrine and angiotensin II. Elucidating the foundational sources of sexually dimorphic traits in the regulation of baroreceptor reflex may enable the design of more appropriate sex-tailored therapeutic treatments in the future.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280248
Caeiro, Ximena Elizabeth; Mir, Franco Rafael; Vivas, Laura Marta; Carrer, Hugo Felipe; Cambiasso, Maria Julia; Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response; Lippincott Williams; Hypertension; 58; 3; 7-2011; 505-511
0194-911X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280248
identifier_str_mv Caeiro, Ximena Elizabeth; Mir, Franco Rafael; Vivas, Laura Marta; Carrer, Hugo Felipe; Cambiasso, Maria Julia; Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response; Lippincott Williams; Hypertension; 58; 3; 7-2011; 505-511
0194-911X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://hyper.ahajournals.org/content/58/3/505.long
info:eu-repo/semantics/altIdentifier/doi/10.1161/HYPERTENSIONAHA.111.175661
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.106097

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