Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice

Autores
Burns, Patricia Graciela; Alard, Jeanne; Hrdỳ, Jiri; Boutillier, Denise; Paez, Roxana Beatriz; Reinheimer, Jorge Alberto; Pot, Bruno; Vinderola, Celso Gabriel; Grangette, Corinne
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gut microbiota dysbiosis plays a central role in the development and perpetuation of chronic inflammation in inflammatory bowel disease (IBD) and therefore is key target for interventions with high quality and functional probiotics. The local production of stable probiotic formulations at limited cost is considered an advantage as it reduces transportation cost and time, thereby increasing the effective period at the consumer side. In the present study, we compared the anti-inflammatory capacities of the Bifidobacterium animalis subsp. lactis (B. lactis) INL1, a probiotic strain isolated in Argentina from human breast milk, with the commercial strain B. animalis subsp. lactis BB12. The impact of spray-drying, a low-cost alternative of bacterial dehydration, on the functionality of both bifidobacteria was also investigated. We showed for both bacteria that the spray-drying process did not impact on bacterial survival nor on their protective capacities against acute and chronic colitis in mice, opening future perspectives for the use of strain INL1 in populations with IBD.
EEA Rafaela
Fil: Burns, Patricia Graciela. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; Argentina
Fil: Alard, Jeanne. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fil: Hrdỳ, Jiri. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia. Charles University and General University Hospital. First Faculty of Medicine. Institute of Immunology and Microbiology; República Checa
Fil: Boutillier, Denise. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fil: Paez, Roxana Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Reinheimer, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; Argentina
Fil: Pot, Bruno. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; Argentina
Fil: Grangette, Corinne. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fuente
Scientific Reports 7, Article number: 43211 (February 2017)
Materia
Bifidobacterium
Ratón
Colitis
Enfermedades Intestinales
Secado por Pulverización
Mice
Intestinal Diseases
Spray Drying
Bifidobacterium lactis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/3475
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network_name_str INTA Digital (INTA)
spelling Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in miceBurns, Patricia GracielaAlard, JeanneHrdỳ, JiriBoutillier, DenisePaez, Roxana BeatrizReinheimer, Jorge AlbertoPot, BrunoVinderola, Celso GabrielGrangette, CorinneBifidobacteriumRatónColitisEnfermedades IntestinalesSecado por PulverizaciónMiceIntestinal DiseasesSpray DryingBifidobacterium lactisGut microbiota dysbiosis plays a central role in the development and perpetuation of chronic inflammation in inflammatory bowel disease (IBD) and therefore is key target for interventions with high quality and functional probiotics. The local production of stable probiotic formulations at limited cost is considered an advantage as it reduces transportation cost and time, thereby increasing the effective period at the consumer side. In the present study, we compared the anti-inflammatory capacities of the Bifidobacterium animalis subsp. lactis (B. lactis) INL1, a probiotic strain isolated in Argentina from human breast milk, with the commercial strain B. animalis subsp. lactis BB12. The impact of spray-drying, a low-cost alternative of bacterial dehydration, on the functionality of both bifidobacteria was also investigated. We showed for both bacteria that the spray-drying process did not impact on bacterial survival nor on their protective capacities against acute and chronic colitis in mice, opening future perspectives for the use of strain INL1 in populations with IBD.EEA RafaelaFil: Burns, Patricia Graciela. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; ArgentinaFil: Alard, Jeanne. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; FranciaFil: Hrdỳ, Jiri. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia. Charles University and General University Hospital. First Faculty of Medicine. Institute of Immunology and Microbiology; República ChecaFil: Boutillier, Denise. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; FranciaFil: Paez, Roxana Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Reinheimer, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; ArgentinaFil: Pot, Bruno. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; FranciaFil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; ArgentinaFil: Grangette, Corinne. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia2018-09-26T13:40:36Z2018-09-26T13:40:36Z2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.nature.com/articles/srep43211http://hdl.handle.net/20.500.12123/34752045-2322https://doi.org/10.1038/srep43211Scientific Reports 7, Article number: 43211 (February 2017)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:47:29Zoai:localhost:20.500.12123/3475instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:34.685INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
title Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
spellingShingle Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
Burns, Patricia Graciela
Bifidobacterium
Ratón
Colitis
Enfermedades Intestinales
Secado por Pulverización
Mice
Intestinal Diseases
Spray Drying
Bifidobacterium lactis
title_short Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
title_full Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
title_fullStr Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
title_full_unstemmed Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
title_sort Spray-drying process preserves the protective capacity of a breast milk-derived Bifidobacterium lactis strain on acute and chronic colitis in mice
dc.creator.none.fl_str_mv Burns, Patricia Graciela
Alard, Jeanne
Hrdỳ, Jiri
Boutillier, Denise
Paez, Roxana Beatriz
Reinheimer, Jorge Alberto
Pot, Bruno
Vinderola, Celso Gabriel
Grangette, Corinne
author Burns, Patricia Graciela
author_facet Burns, Patricia Graciela
Alard, Jeanne
Hrdỳ, Jiri
Boutillier, Denise
Paez, Roxana Beatriz
Reinheimer, Jorge Alberto
Pot, Bruno
Vinderola, Celso Gabriel
Grangette, Corinne
author_role author
author2 Alard, Jeanne
Hrdỳ, Jiri
Boutillier, Denise
Paez, Roxana Beatriz
Reinheimer, Jorge Alberto
Pot, Bruno
Vinderola, Celso Gabriel
Grangette, Corinne
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bifidobacterium
Ratón
Colitis
Enfermedades Intestinales
Secado por Pulverización
Mice
Intestinal Diseases
Spray Drying
Bifidobacterium lactis
topic Bifidobacterium
Ratón
Colitis
Enfermedades Intestinales
Secado por Pulverización
Mice
Intestinal Diseases
Spray Drying
Bifidobacterium lactis
dc.description.none.fl_txt_mv Gut microbiota dysbiosis plays a central role in the development and perpetuation of chronic inflammation in inflammatory bowel disease (IBD) and therefore is key target for interventions with high quality and functional probiotics. The local production of stable probiotic formulations at limited cost is considered an advantage as it reduces transportation cost and time, thereby increasing the effective period at the consumer side. In the present study, we compared the anti-inflammatory capacities of the Bifidobacterium animalis subsp. lactis (B. lactis) INL1, a probiotic strain isolated in Argentina from human breast milk, with the commercial strain B. animalis subsp. lactis BB12. The impact of spray-drying, a low-cost alternative of bacterial dehydration, on the functionality of both bifidobacteria was also investigated. We showed for both bacteria that the spray-drying process did not impact on bacterial survival nor on their protective capacities against acute and chronic colitis in mice, opening future perspectives for the use of strain INL1 in populations with IBD.
EEA Rafaela
Fil: Burns, Patricia Graciela. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; Argentina
Fil: Alard, Jeanne. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fil: Hrdỳ, Jiri. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia. Charles University and General University Hospital. First Faculty of Medicine. Institute of Immunology and Microbiology; República Checa
Fil: Boutillier, Denise. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fil: Paez, Roxana Beatriz. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Reinheimer, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; Argentina
Fil: Pot, Bruno. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
Fil: Vinderola, Celso Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Lactologia Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactologia Industrial; Argentina
Fil: Grangette, Corinne. Universite Lille. CNRS, Inserm. CHU Lille. Institut Pasteur de Lille; Francia
description Gut microbiota dysbiosis plays a central role in the development and perpetuation of chronic inflammation in inflammatory bowel disease (IBD) and therefore is key target for interventions with high quality and functional probiotics. The local production of stable probiotic formulations at limited cost is considered an advantage as it reduces transportation cost and time, thereby increasing the effective period at the consumer side. In the present study, we compared the anti-inflammatory capacities of the Bifidobacterium animalis subsp. lactis (B. lactis) INL1, a probiotic strain isolated in Argentina from human breast milk, with the commercial strain B. animalis subsp. lactis BB12. The impact of spray-drying, a low-cost alternative of bacterial dehydration, on the functionality of both bifidobacteria was also investigated. We showed for both bacteria that the spray-drying process did not impact on bacterial survival nor on their protective capacities against acute and chronic colitis in mice, opening future perspectives for the use of strain INL1 in populations with IBD.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
2018-09-26T13:40:36Z
2018-09-26T13:40:36Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.nature.com/articles/srep43211
http://hdl.handle.net/20.500.12123/3475
2045-2322
https://doi.org/10.1038/srep43211
url https://www.nature.com/articles/srep43211
http://hdl.handle.net/20.500.12123/3475
https://doi.org/10.1038/srep43211
identifier_str_mv 2045-2322
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scientific Reports 7, Article number: 43211 (February 2017)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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