First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure

Autores
Serena, Maria Soledad; Cappuccio, Javier Alejandro; Barrales, Hernán; Metz, German Ernesto; Aspitia, C.G.; Lozada, María Inés; Perfumo, Carlos Juan; Quiroga, María Alejandra; Piñeyro, Pablo; Echeverria, Maria Gabriela
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Porcine circovirus type 3 (PCV3) is considered a new circovirus and since it first description has been widely reported in most of the swine producing countries. Multisystemic inflammation and reproductive failure are consistent and concerning issues associated with PCV3 infection. This report describes the clinical and pathological features of a chronic reproductive disorder in a swine‐herd in Argentina associated with the presence of PCV3. Mummified (n=42) and stillborn piglets (n=20) from a case of chronic reproductive disorder (Study A) and mummified and stillborn piglets (n=141) from normal deliveries (Study B) were retrospectively assessed for the presence of multiple reproductive pathogens (PCV3, PCV2, ADV, PPV, Leptospira spp., and Brucella spp). On study, A PCV3 and PPV were detected in 15 and 8 pools respectively with a coinfection rate of 100% in all PPV positive cases. Three out of 131 fetuses from three different sows from Study B were positive only for PCV3. Histological evaluation of hearts from stillborn also showed lesions similar to those previously described in the literature for PCV3‐reproductive disease. Partial genome of PCV3 was amplified and phylogenetic analysis showed that strains of Study A and B clustered within the PCV3a and PCV3b clades respectively. This study demonstrates, for the first time, the PCV3 has been circulating in Argentina at least since 2016 and its potential role in reproductive disorders. Further studies are warranted to determine the role of PCV3 in the reproductive disease complex and its prevalence in the swine industry in Argentina.
EEA Marcos Juárez
Fil: Serena, Maria Soledad. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Barrales, Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Medicina Porcina; Argentina
Fil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aspitia, C.G. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina.
Fil: Lozada, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Medicina Porcina; Argentina
Fil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Patología Especial Veterinaria; Argentina
Fil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Patología Especial Veterinaria; Argentina
Fil: Piñeyro, Pablo. Iowa State University. College of Veterinary Medicine. Department of Veterinary Diagnostic and Production Animal Medicine; Estados Unidos
Fil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Transboundary and Emerging Diseases (First published: 27 October 2020)
Materia
Cerdo
Enfermedades de los Animales
Circovirus Porcino
Reproducción
Argentina
Swine
Animal Diseases
Porcine Circovirus
Reproduction
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/8192
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oai_identifier_str oai:localhost:20.500.12123/8192
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network_name_str INTA Digital (INTA)
spelling First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failureSerena, Maria SoledadCappuccio, Javier AlejandroBarrales, HernánMetz, German ErnestoAspitia, C.G.Lozada, María InésPerfumo, Carlos JuanQuiroga, María AlejandraPiñeyro, PabloEcheverria, Maria GabrielaCerdoEnfermedades de los AnimalesCircovirus PorcinoReproducciónArgentinaSwineAnimal DiseasesPorcine CircovirusReproductionPorcine circovirus type 3 (PCV3) is considered a new circovirus and since it first description has been widely reported in most of the swine producing countries. Multisystemic inflammation and reproductive failure are consistent and concerning issues associated with PCV3 infection. This report describes the clinical and pathological features of a chronic reproductive disorder in a swine‐herd in Argentina associated with the presence of PCV3. Mummified (n=42) and stillborn piglets (n=20) from a case of chronic reproductive disorder (Study A) and mummified and stillborn piglets (n=141) from normal deliveries (Study B) were retrospectively assessed for the presence of multiple reproductive pathogens (PCV3, PCV2, ADV, PPV, Leptospira spp., and Brucella spp). On study, A PCV3 and PPV were detected in 15 and 8 pools respectively with a coinfection rate of 100% in all PPV positive cases. Three out of 131 fetuses from three different sows from Study B were positive only for PCV3. Histological evaluation of hearts from stillborn also showed lesions similar to those previously described in the literature for PCV3‐reproductive disease. Partial genome of PCV3 was amplified and phylogenetic analysis showed that strains of Study A and B clustered within the PCV3a and PCV3b clades respectively. This study demonstrates, for the first time, the PCV3 has been circulating in Argentina at least since 2016 and its potential role in reproductive disorders. Further studies are warranted to determine the role of PCV3 in the reproductive disease complex and its prevalence in the swine industry in Argentina.EEA Marcos JuárezFil: Serena, Maria Soledad. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Barrales, Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Medicina Porcina; ArgentinaFil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aspitia, C.G. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina.Fil: Lozada, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Medicina Porcina; ArgentinaFil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Patología Especial Veterinaria; ArgentinaFil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Patología Especial Veterinaria; ArgentinaFil: Piñeyro, Pablo. Iowa State University. College of Veterinary Medicine. Department of Veterinary Diagnostic and Production Animal Medicine; Estados UnidosFil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWileyinfo:eu-repo/date/embargoEnd/2021-11-042020-11-04T17:53:52Z2020-11-04T17:53:52Z2020-10-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/8192https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.138931865-16741865-1682https://doi.org/10.1111/tbed.13893Transboundary and Emerging Diseases (First published: 27 October 2020)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:48:40Zoai:localhost:20.500.12123/8192instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:48:41.457INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
spellingShingle First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
Serena, Maria Soledad
Cerdo
Enfermedades de los Animales
Circovirus Porcino
Reproducción
Argentina
Swine
Animal Diseases
Porcine Circovirus
Reproduction
title_short First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_full First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_fullStr First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_full_unstemmed First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
title_sort First detection and genetic characterization of porcine circovirus type 3 (PCV3) in Argentina and its association with reproductive failure
dc.creator.none.fl_str_mv Serena, Maria Soledad
Cappuccio, Javier Alejandro
Barrales, Hernán
Metz, German Ernesto
Aspitia, C.G.
Lozada, María Inés
Perfumo, Carlos Juan
Quiroga, María Alejandra
Piñeyro, Pablo
Echeverria, Maria Gabriela
author Serena, Maria Soledad
author_facet Serena, Maria Soledad
Cappuccio, Javier Alejandro
Barrales, Hernán
Metz, German Ernesto
Aspitia, C.G.
Lozada, María Inés
Perfumo, Carlos Juan
Quiroga, María Alejandra
Piñeyro, Pablo
Echeverria, Maria Gabriela
author_role author
author2 Cappuccio, Javier Alejandro
Barrales, Hernán
Metz, German Ernesto
Aspitia, C.G.
Lozada, María Inés
Perfumo, Carlos Juan
Quiroga, María Alejandra
Piñeyro, Pablo
Echeverria, Maria Gabriela
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cerdo
Enfermedades de los Animales
Circovirus Porcino
Reproducción
Argentina
Swine
Animal Diseases
Porcine Circovirus
Reproduction
topic Cerdo
Enfermedades de los Animales
Circovirus Porcino
Reproducción
Argentina
Swine
Animal Diseases
Porcine Circovirus
Reproduction
dc.description.none.fl_txt_mv Porcine circovirus type 3 (PCV3) is considered a new circovirus and since it first description has been widely reported in most of the swine producing countries. Multisystemic inflammation and reproductive failure are consistent and concerning issues associated with PCV3 infection. This report describes the clinical and pathological features of a chronic reproductive disorder in a swine‐herd in Argentina associated with the presence of PCV3. Mummified (n=42) and stillborn piglets (n=20) from a case of chronic reproductive disorder (Study A) and mummified and stillborn piglets (n=141) from normal deliveries (Study B) were retrospectively assessed for the presence of multiple reproductive pathogens (PCV3, PCV2, ADV, PPV, Leptospira spp., and Brucella spp). On study, A PCV3 and PPV were detected in 15 and 8 pools respectively with a coinfection rate of 100% in all PPV positive cases. Three out of 131 fetuses from three different sows from Study B were positive only for PCV3. Histological evaluation of hearts from stillborn also showed lesions similar to those previously described in the literature for PCV3‐reproductive disease. Partial genome of PCV3 was amplified and phylogenetic analysis showed that strains of Study A and B clustered within the PCV3a and PCV3b clades respectively. This study demonstrates, for the first time, the PCV3 has been circulating in Argentina at least since 2016 and its potential role in reproductive disorders. Further studies are warranted to determine the role of PCV3 in the reproductive disease complex and its prevalence in the swine industry in Argentina.
EEA Marcos Juárez
Fil: Serena, Maria Soledad. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Barrales, Hernán. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Medicina Porcina; Argentina
Fil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aspitia, C.G. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina.
Fil: Lozada, María Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Medicina Porcina; Argentina
Fil: Perfumo, Carlos Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Patología Especial Veterinaria; Argentina
Fil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Patología Especial Veterinaria; Argentina
Fil: Piñeyro, Pablo. Iowa State University. College of Veterinary Medicine. Department of Veterinary Diagnostic and Production Animal Medicine; Estados Unidos
Fil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Porcine circovirus type 3 (PCV3) is considered a new circovirus and since it first description has been widely reported in most of the swine producing countries. Multisystemic inflammation and reproductive failure are consistent and concerning issues associated with PCV3 infection. This report describes the clinical and pathological features of a chronic reproductive disorder in a swine‐herd in Argentina associated with the presence of PCV3. Mummified (n=42) and stillborn piglets (n=20) from a case of chronic reproductive disorder (Study A) and mummified and stillborn piglets (n=141) from normal deliveries (Study B) were retrospectively assessed for the presence of multiple reproductive pathogens (PCV3, PCV2, ADV, PPV, Leptospira spp., and Brucella spp). On study, A PCV3 and PPV were detected in 15 and 8 pools respectively with a coinfection rate of 100% in all PPV positive cases. Three out of 131 fetuses from three different sows from Study B were positive only for PCV3. Histological evaluation of hearts from stillborn also showed lesions similar to those previously described in the literature for PCV3‐reproductive disease. Partial genome of PCV3 was amplified and phylogenetic analysis showed that strains of Study A and B clustered within the PCV3a and PCV3b clades respectively. This study demonstrates, for the first time, the PCV3 has been circulating in Argentina at least since 2016 and its potential role in reproductive disorders. Further studies are warranted to determine the role of PCV3 in the reproductive disease complex and its prevalence in the swine industry in Argentina.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-04T17:53:52Z
2020-11-04T17:53:52Z
2020-10-27
info:eu-repo/date/embargoEnd/2021-11-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/8192
https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13893
1865-1674
1865-1682
https://doi.org/10.1111/tbed.13893
url http://hdl.handle.net/20.500.12123/8192
https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.13893
https://doi.org/10.1111/tbed.13893
identifier_str_mv 1865-1674
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dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Transboundary and Emerging Diseases (First published: 27 October 2020)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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