Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm

Autores
Serena, Maria Soledad; Dibarbora, Marina; Olivera, Valeria Soledad; Metz, German Ernesto; Aspitia, Carolina Gabriela; Pereda, Ariel Julian; Echeverria, Maria Gabriela; Cappuccio, Javier Alejandro
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Porcine circovirus type 2 (PCV2) and protoparvovirus 1 (PPV) were detected as single infection (6/131) and (11/131) respectively, or co-infection (6/131) in fetuses and stillborn piglets from normal deliveries in a farm without reproductive problems. Twenty in twenty-three positive samples were over 70 days of gestation, which is when the fetus becomes immunocompetent, and the presence of a NADL-2 PPV strain suggests fetal immune system impairment. Phylogenetic analysis of sequences obtained showed that 8/9 sequences are related to cluster 13 and the remaining is grouped into cluster 11 sequences. An increase in variability in ORF2 sequences in Argentina was observed. It is not clear whether the detection of fetuses positive to PPV and PCV2 is of epidemiological importance in a subclinically affected farm. However, the results of this study showed that currently used vaccines and vaccine protocols do not fully protect against PPV or PCV2 fetus infection.
Instituto de Virología
Fil: Serena, Maria Soledad. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Serena, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dibarbora, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aspitia, Carolina Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Programa Salud Animal; Argentina
Fil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina
Fil: Cappuccio, Javier Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Infection, Genetics and Evolution 89 : 104735 (Abril 2021)
Materia
Porcine Circovirus
Foetus
Porcine Parvovirus
Phylogeny
Piglets
Vaccines
Epidemiology
Circovirus Porcino
Feto
Parvovirus Porcino
Filogenia
Lechón
Vacuna
Epidemiología
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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oai_identifier_str oai:localhost:20.500.12123/9216
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network_name_str INTA Digital (INTA)
spelling Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farmSerena, Maria SoledadDibarbora, MarinaOlivera, Valeria SoledadMetz, German ErnestoAspitia, Carolina GabrielaPereda, Ariel JulianEcheverria, Maria GabrielaCappuccio, Javier AlejandroPorcine CircovirusFoetusPorcine ParvovirusPhylogenyPigletsVaccinesEpidemiologyCircovirus PorcinoFetoParvovirus PorcinoFilogeniaLechónVacunaEpidemiologíaPorcine circovirus type 2 (PCV2) and protoparvovirus 1 (PPV) were detected as single infection (6/131) and (11/131) respectively, or co-infection (6/131) in fetuses and stillborn piglets from normal deliveries in a farm without reproductive problems. Twenty in twenty-three positive samples were over 70 days of gestation, which is when the fetus becomes immunocompetent, and the presence of a NADL-2 PPV strain suggests fetal immune system impairment. Phylogenetic analysis of sequences obtained showed that 8/9 sequences are related to cluster 13 and the remaining is grouped into cluster 11 sequences. An increase in variability in ORF2 sequences in Argentina was observed. It is not clear whether the detection of fetuses positive to PPV and PCV2 is of epidemiological importance in a subclinically affected farm. However, the results of this study showed that currently used vaccines and vaccine protocols do not fully protect against PPV or PCV2 fetus infection.Instituto de VirologíaFil: Serena, Maria Soledad. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; ArgentinaFil: Serena, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dibarbora, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; ArgentinaFil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aspitia, Carolina Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; ArgentinaFil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Programa Salud Animal; ArgentinaFil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; ArgentinaFil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; ArgentinaFil: Cappuccio, Javier Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2021-04-28T18:12:26Z2021-04-28T18:12:26Z2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/9216https://www.sciencedirect.com/science/article/abs/pii/S15671348210003201567-1348https://doi.org/10.1016/j.meegid.2021.104735Infection, Genetics and Evolution 89 : 104735 (Abril 2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PD-E5-I103-001/2019-PD-E5-I103-001/AR./Desarrollo de tecnologías diagnósticas y estudios epidemiológicos para el control de enfermedades que afectan la producción animal y la salud públicainfo:eu-repo/semantics/restrictedAccess2025-09-04T09:48:52Zoai:localhost:20.500.12123/9216instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:48:53.032INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
title Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
spellingShingle Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
Serena, Maria Soledad
Porcine Circovirus
Foetus
Porcine Parvovirus
Phylogeny
Piglets
Vaccines
Epidemiology
Circovirus Porcino
Feto
Parvovirus Porcino
Filogenia
Lechón
Vacuna
Epidemiología
title_short Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
title_full Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
title_fullStr Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
title_full_unstemmed Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
title_sort Evidence of porcine circovirus type 2 and co-infection with ungulate protoparvovirus 1 (porcine parvovirus) in mummies and stillborn piglets in subclinically infected farm
dc.creator.none.fl_str_mv Serena, Maria Soledad
Dibarbora, Marina
Olivera, Valeria Soledad
Metz, German Ernesto
Aspitia, Carolina Gabriela
Pereda, Ariel Julian
Echeverria, Maria Gabriela
Cappuccio, Javier Alejandro
author Serena, Maria Soledad
author_facet Serena, Maria Soledad
Dibarbora, Marina
Olivera, Valeria Soledad
Metz, German Ernesto
Aspitia, Carolina Gabriela
Pereda, Ariel Julian
Echeverria, Maria Gabriela
Cappuccio, Javier Alejandro
author_role author
author2 Dibarbora, Marina
Olivera, Valeria Soledad
Metz, German Ernesto
Aspitia, Carolina Gabriela
Pereda, Ariel Julian
Echeverria, Maria Gabriela
Cappuccio, Javier Alejandro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Porcine Circovirus
Foetus
Porcine Parvovirus
Phylogeny
Piglets
Vaccines
Epidemiology
Circovirus Porcino
Feto
Parvovirus Porcino
Filogenia
Lechón
Vacuna
Epidemiología
topic Porcine Circovirus
Foetus
Porcine Parvovirus
Phylogeny
Piglets
Vaccines
Epidemiology
Circovirus Porcino
Feto
Parvovirus Porcino
Filogenia
Lechón
Vacuna
Epidemiología
dc.description.none.fl_txt_mv Porcine circovirus type 2 (PCV2) and protoparvovirus 1 (PPV) were detected as single infection (6/131) and (11/131) respectively, or co-infection (6/131) in fetuses and stillborn piglets from normal deliveries in a farm without reproductive problems. Twenty in twenty-three positive samples were over 70 days of gestation, which is when the fetus becomes immunocompetent, and the presence of a NADL-2 PPV strain suggests fetal immune system impairment. Phylogenetic analysis of sequences obtained showed that 8/9 sequences are related to cluster 13 and the remaining is grouped into cluster 11 sequences. An increase in variability in ORF2 sequences in Argentina was observed. It is not clear whether the detection of fetuses positive to PPV and PCV2 is of epidemiological importance in a subclinically affected farm. However, the results of this study showed that currently used vaccines and vaccine protocols do not fully protect against PPV or PCV2 fetus infection.
Instituto de Virología
Fil: Serena, Maria Soledad. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Serena, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Dibarbora, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Metz, German Ernesto. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aspitia, Carolina Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Pereda, Ariel Julian. Instituto Nacional de Tecnología Agropecuaria (INTA). Programa Salud Animal; Argentina
Fil: Echeverria, Maria Gabriela. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Laboratorio de Virología; Argentina
Fil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cappuccio, Javier Alejandro. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Marcos Juárez; Argentina
Fil: Cappuccio, Javier Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Porcine circovirus type 2 (PCV2) and protoparvovirus 1 (PPV) were detected as single infection (6/131) and (11/131) respectively, or co-infection (6/131) in fetuses and stillborn piglets from normal deliveries in a farm without reproductive problems. Twenty in twenty-three positive samples were over 70 days of gestation, which is when the fetus becomes immunocompetent, and the presence of a NADL-2 PPV strain suggests fetal immune system impairment. Phylogenetic analysis of sequences obtained showed that 8/9 sequences are related to cluster 13 and the remaining is grouped into cluster 11 sequences. An increase in variability in ORF2 sequences in Argentina was observed. It is not clear whether the detection of fetuses positive to PPV and PCV2 is of epidemiological importance in a subclinically affected farm. However, the results of this study showed that currently used vaccines and vaccine protocols do not fully protect against PPV or PCV2 fetus infection.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-28T18:12:26Z
2021-04-28T18:12:26Z
2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/9216
https://www.sciencedirect.com/science/article/abs/pii/S1567134821000320
1567-1348
https://doi.org/10.1016/j.meegid.2021.104735
url http://hdl.handle.net/20.500.12123/9216
https://www.sciencedirect.com/science/article/abs/pii/S1567134821000320
https://doi.org/10.1016/j.meegid.2021.104735
identifier_str_mv 1567-1348
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PD-E5-I103-001/2019-PD-E5-I103-001/AR./Desarrollo de tecnologías diagnósticas y estudios epidemiológicos para el control de enfermedades que afectan la producción animal y la salud pública
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Infection, Genetics and Evolution 89 : 104735 (Abril 2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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