Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis

Autores
Bigi, María Mercedes; Blanco, Federico Carlos; Araujo, Flabio Ribeiro de; Thacker, Tyler C.; Zumarraga, Martin Jose; Cataldi, Angel Adrian; Soria, Marcelo Abel; Bigi, Fabiana
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis
Inst. de Biotecnología
Fil: Bigi, María Mercedes. Universidad de Buenos Aires; Argentina
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Araujo, Flabio R. EMBRAPA Mato Grosso do Sul; Brasil
Fil: Thacker, Tyler C. United States Department of Agriculture. Agricultural Research Service. National Animal Disease Center; Estados Unidos
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Microbiología Agrícola; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fuente
Microbiology and Immunology 60 (8) : 552–560. (August 2016)
Materia
Enfermedades de los Animales
Mycobacterium Tuberculosis
Mycobacterium Bovis
Enfermedades Infecciosas
Polimorfismo
Animal Diseases
Infectious Diseases
Polymorphism
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/1186
Acceder
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network_name_str INTA Digital (INTA)
spelling Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovisBigi, María MercedesBlanco, Federico CarlosAraujo, Flabio Ribeiro deThacker, Tyler C.Zumarraga, Martin JoseCataldi, Angel AdrianSoria, Marcelo AbelBigi, FabianaEnfermedades de los AnimalesMycobacterium TuberculosisMycobacterium BovisEnfermedades InfecciosasPolimorfismoAnimal DiseasesInfectious DiseasesPolymorphismMycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosisInst. de BiotecnologíaFil: Bigi, María Mercedes. Universidad de Buenos Aires; ArgentinaFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Araujo, Flabio R. EMBRAPA Mato Grosso do Sul; BrasilFil: Thacker, Tyler C. United States Department of Agriculture. Agricultural Research Service. National Animal Disease Center; Estados UnidosFil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Microbiología Agrícola; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; ArgentinaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina2017-09-11T12:26:47Z2017-09-11T12:26:47Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/11860385-5600 (Print)1348-0421 (Online)DOI: 10.1111/1348-0421.12402Microbiology and Immunology 60 (8) : 552–560. (August 2016)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-04T09:47:01Zoai:localhost:20.500.12123/1186instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:01.9INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
spellingShingle Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
Bigi, María Mercedes
Enfermedades de los Animales
Mycobacterium Tuberculosis
Mycobacterium Bovis
Enfermedades Infecciosas
Polimorfismo
Animal Diseases
Infectious Diseases
Polymorphism
title_short Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_full Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_fullStr Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_full_unstemmed Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_sort Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
dc.creator.none.fl_str_mv Bigi, María Mercedes
Blanco, Federico Carlos
Araujo, Flabio Ribeiro de
Thacker, Tyler C.
Zumarraga, Martin Jose
Cataldi, Angel Adrian
Soria, Marcelo Abel
Bigi, Fabiana
author Bigi, María Mercedes
author_facet Bigi, María Mercedes
Blanco, Federico Carlos
Araujo, Flabio Ribeiro de
Thacker, Tyler C.
Zumarraga, Martin Jose
Cataldi, Angel Adrian
Soria, Marcelo Abel
Bigi, Fabiana
author_role author
author2 Blanco, Federico Carlos
Araujo, Flabio Ribeiro de
Thacker, Tyler C.
Zumarraga, Martin Jose
Cataldi, Angel Adrian
Soria, Marcelo Abel
Bigi, Fabiana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedades de los Animales
Mycobacterium Tuberculosis
Mycobacterium Bovis
Enfermedades Infecciosas
Polimorfismo
Animal Diseases
Infectious Diseases
Polymorphism
topic Enfermedades de los Animales
Mycobacterium Tuberculosis
Mycobacterium Bovis
Enfermedades Infecciosas
Polimorfismo
Animal Diseases
Infectious Diseases
Polymorphism
dc.description.none.fl_txt_mv Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis
Inst. de Biotecnología
Fil: Bigi, María Mercedes. Universidad de Buenos Aires; Argentina
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Araujo, Flabio R. EMBRAPA Mato Grosso do Sul; Brasil
Fil: Thacker, Tyler C. United States Department of Agriculture. Agricultural Research Service. National Animal Disease Center; Estados Unidos
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Microbiología Agrícola; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
description Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis
publishDate 2016
dc.date.none.fl_str_mv 2016
2017-09-11T12:26:47Z
2017-09-11T12:26:47Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/1186
0385-5600 (Print)
1348-0421 (Online)
DOI: 10.1111/1348-0421.12402
url http://hdl.handle.net/20.500.12123/1186
identifier_str_mv 0385-5600 (Print)
1348-0421 (Online)
DOI: 10.1111/1348-0421.12402
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Microbiology and Immunology 60 (8) : 552–560. (August 2016)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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