Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis

Autores
Bigi, María M.; Blanco, Federico Carlos; Araújo, Flabio R.; Thacker, Tyler C.; Zumárraga, Martín José; Cataldi, Ángel Adrián; Soria, Marcelo A.; Bigi, Fabiana
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
Fil: Bigi, María M.. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Araújo, Flabio R.. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; Brasil
Fil: Thacker, Tyler C.. United States Department of Agriculture. Agriculture Research Service; Estados Unidos
Fil: Zumárraga, Martín José. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cataldi, Ángel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo A.. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
MYCOBACTERIUM BOVIS
MYCOBACTERIUM TUBERCULOSIS
POLYMORPHISM
REGULATOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115328
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/115328
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovisBigi, María M.Blanco, Federico CarlosAraújo, Flabio R.Thacker, Tyler C.Zumárraga, Martín JoséCataldi, Ángel AdriánSoria, Marcelo A.Bigi, FabianaMYCOBACTERIUM BOVISMYCOBACTERIUM TUBERCULOSISPOLYMORPHISMREGULATORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.Fil: Bigi, María M.. Universidad de Buenos Aires. Facultad de Agronomía; ArgentinaFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Araújo, Flabio R.. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; BrasilFil: Thacker, Tyler C.. United States Department of Agriculture. Agriculture Research Service; Estados UnidosFil: Zumárraga, Martín José. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cataldi, Ángel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Soria, Marcelo A.. Universidad de Buenos Aires. Facultad de Agronomía; ArgentinaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115328Bigi, María M.; Blanco, Federico Carlos; Araújo, Flabio R.; Thacker, Tyler C.; Zumárraga, Martín José; et al.; Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis; Wiley Blackwell Publishing, Inc; Microbiology And Immunology; 60; 8; 8-2016; 552-5600385-5600CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/wol1/doi/10.1111/1348-0421.12402/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/1348-0421.12402info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:08Zoai:ri.conicet.gov.ar:11336/115328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:08.626CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
spellingShingle Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
Bigi, María M.
MYCOBACTERIUM BOVIS
MYCOBACTERIUM TUBERCULOSIS
POLYMORPHISM
REGULATOR
title_short Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_full Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_fullStr Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_full_unstemmed Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
title_sort Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis
dc.creator.none.fl_str_mv Bigi, María M.
Blanco, Federico Carlos
Araújo, Flabio R.
Thacker, Tyler C.
Zumárraga, Martín José
Cataldi, Ángel Adrián
Soria, Marcelo A.
Bigi, Fabiana
author Bigi, María M.
author_facet Bigi, María M.
Blanco, Federico Carlos
Araújo, Flabio R.
Thacker, Tyler C.
Zumárraga, Martín José
Cataldi, Ángel Adrián
Soria, Marcelo A.
Bigi, Fabiana
author_role author
author2 Blanco, Federico Carlos
Araújo, Flabio R.
Thacker, Tyler C.
Zumárraga, Martín José
Cataldi, Ángel Adrián
Soria, Marcelo A.
Bigi, Fabiana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MYCOBACTERIUM BOVIS
MYCOBACTERIUM TUBERCULOSIS
POLYMORPHISM
REGULATOR
topic MYCOBACTERIUM BOVIS
MYCOBACTERIUM TUBERCULOSIS
POLYMORPHISM
REGULATOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
Fil: Bigi, María M.. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Araújo, Flabio R.. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; Brasil
Fil: Thacker, Tyler C.. United States Department of Agriculture. Agriculture Research Service; Estados Unidos
Fil: Zumárraga, Martín José. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cataldi, Ángel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Soria, Marcelo A.. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115328
Bigi, María M.; Blanco, Federico Carlos; Araújo, Flabio R.; Thacker, Tyler C.; Zumárraga, Martín José; et al.; Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis; Wiley Blackwell Publishing, Inc; Microbiology And Immunology; 60; 8; 8-2016; 552-560
0385-5600
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115328
identifier_str_mv Bigi, María M.; Blanco, Federico Carlos; Araújo, Flabio R.; Thacker, Tyler C.; Zumárraga, Martín José; et al.; Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis; Wiley Blackwell Publishing, Inc; Microbiology And Immunology; 60; 8; 8-2016; 552-560
0385-5600
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/wol1/doi/10.1111/1348-0421.12402/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/1348-0421.12402
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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