Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

Autores
Garcia, Elizabeth Andrea; Bianco, Marí­a Veronica; Blanco, Federico Carlos; Bigi, Fabiana
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..
Inst. de Biotecnología
Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Bianco, Marí­a Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; Argentina
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fuente
Journal Of Infection In Developing Countries 10 (8): 892-894 (August 2016)
Materia
Enfermedades de los Animales
Mycobacterium Bovis
Tuberculosis
Infección por Mycobacterium Bovis
Animal Diseases
Mycobacterium Bovis Infections
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/1053
Acceder
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spelling Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosisGarcia, Elizabeth AndreaBianco, Marí­a VeronicaBlanco, Federico CarlosBigi, FabianaEnfermedades de los AnimalesMycobacterium BovisTuberculosisInfección por Mycobacterium BovisAnimal DiseasesMycobacterium Bovis InfectionsHere we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..Inst. de BiotecnologíaFil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Bianco, Marí­a Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; ArgentinaFil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina2017-08-28T13:59:35Z2017-08-28T13:59:35Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/1053https://jidc.org/index.php/journal/article/view/27580338/1568García E, Bianco M, Blanco F, Bigi F (2016) Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis. The Journal Of Infection In Developing Countries 10 (08): 892-894. https://doi.org/10.3855/jidc.77212036-6590 (Print)1972-2680 (Online)https://doi.org/10.3855/jidc.7721Journal Of Infection In Developing Countries 10 (8): 892-894 (August 2016)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:44:09Zoai:localhost:20.500.12123/1053instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:09.514INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
title Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
spellingShingle Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
Garcia, Elizabeth Andrea
Enfermedades de los Animales
Mycobacterium Bovis
Tuberculosis
Infección por Mycobacterium Bovis
Animal Diseases
Mycobacterium Bovis Infections
title_short Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
title_full Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
title_fullStr Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
title_full_unstemmed Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
title_sort Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis
dc.creator.none.fl_str_mv Garcia, Elizabeth Andrea
Bianco, Marí­a Veronica
Blanco, Federico Carlos
Bigi, Fabiana
author Garcia, Elizabeth Andrea
author_facet Garcia, Elizabeth Andrea
Bianco, Marí­a Veronica
Blanco, Federico Carlos
Bigi, Fabiana
author_role author
author2 Bianco, Marí­a Veronica
Blanco, Federico Carlos
Bigi, Fabiana
author2_role author
author
author
dc.subject.none.fl_str_mv Enfermedades de los Animales
Mycobacterium Bovis
Tuberculosis
Infección por Mycobacterium Bovis
Animal Diseases
Mycobacterium Bovis Infections
topic Enfermedades de los Animales
Mycobacterium Bovis
Tuberculosis
Infección por Mycobacterium Bovis
Animal Diseases
Mycobacterium Bovis Infections
dc.description.none.fl_txt_mv Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..
Inst. de Biotecnología
Fil: Garcia, Elizabeth Andrea. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Bianco, Marí­a Veronica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Fisiología y Recursos Genéticos Vegetales; Argentina
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
description Here we confirm the efficacy of MbΔmce2-phoP to protect mice against bTB challenge and we demonstrated that this new attenuated strain is safer than our previous bTB vaccine MbΔmce2. Altogether these results support the further assessment of this candidate in cattle model of bTB.Experiments with mice were performed in compliance with the regulations of the Institutional Animal Care and Use Committee (CICUAE) of INTA (61/2014)..
publishDate 2016
dc.date.none.fl_str_mv 2016
2017-08-28T13:59:35Z
2017-08-28T13:59:35Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/1053
https://jidc.org/index.php/journal/article/view/27580338/1568
García E, Bianco M, Blanco F, Bigi F (2016) Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis. The Journal Of Infection In Developing Countries 10 (08): 892-894. https://doi.org/10.3855/jidc.7721
2036-6590 (Print)
1972-2680 (Online)
https://doi.org/10.3855/jidc.7721
url http://hdl.handle.net/20.500.12123/1053
https://jidc.org/index.php/journal/article/view/27580338/1568
https://doi.org/10.3855/jidc.7721
identifier_str_mv García E, Bianco M, Blanco F, Bigi F (2016) Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis. The Journal Of Infection In Developing Countries 10 (08): 892-894. https://doi.org/10.3855/jidc.7721
2036-6590 (Print)
1972-2680 (Online)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Journal Of Infection In Developing Countries 10 (8): 892-894 (August 2016)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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