An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection

Autores
Rossi, Ursula Amaranta; Maurizio, Estefanía; Caffaro, María Eugenia; Poli, Mario Andres; Rossetti, Carlos Alberto
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Poster
Brucella melitensis is the etiological agent of brucellosis in goats and the main cause of human brucellosis. Interferons (IFNs) are important cytokines in the immune responses to intracellular pathogens and tumor cells. Although IFNβ is classically associated with antiviral responses, growing evidence shows that IFNβ is also involved in the cellular response to bacterial infections. IRF3 is a member of the interferon regulatory transcription factor family that plays a critical role in both the early and late phases of the IFNα/β gene induction. In general, it is considered that IRF3 acts as a suppressor of pro-inflammatory genes and an enhancer of anti inflammatory genes. For example, IRF3 can be directly recruited to the IL12B promoter suppressing its expression. It was reported that B. abortus induces IFNβ expression in an IRF3-dependent manner, and that mice lacking the IFNα/β receptor are more resistant to Brucella infection.
Instituto de Patobiología
Fil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Rossi, Ursula Amaranta. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Maurizio, Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Maurizio, Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; Argentina
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Rossetti, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fuente
II Congreso de Microbiología Veterinaria, Facultad de Ciencias Veterinarias, Universidad del Centro de la Provincia de Buenos Aires, 9 al 12 de agosto 2023
Materia
Brucella melitensis
Macrófago
Caprinae
Caprinos
Interferona
Citoquina
Respuesta Inmunológica
Organismo patógeno
Macrophages
Goats
Interferons
Cytokines
Immune Response
Pathogens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/23026
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network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infectionRossi, Ursula AmarantaMaurizio, EstefaníaCaffaro, María EugeniaPoli, Mario AndresRossetti, Carlos AlbertoBrucella melitensisMacrófagoCaprinaeCaprinosInterferonaCitoquinaRespuesta InmunológicaOrganismo patógenoMacrophagesGoatsInterferonsCytokinesImmune ResponsePathogensPosterBrucella melitensis is the etiological agent of brucellosis in goats and the main cause of human brucellosis. Interferons (IFNs) are important cytokines in the immune responses to intracellular pathogens and tumor cells. Although IFNβ is classically associated with antiviral responses, growing evidence shows that IFNβ is also involved in the cellular response to bacterial infections. IRF3 is a member of the interferon regulatory transcription factor family that plays a critical role in both the early and late phases of the IFNα/β gene induction. In general, it is considered that IRF3 acts as a suppressor of pro-inflammatory genes and an enhancer of anti inflammatory genes. For example, IRF3 can be directly recruited to the IL12B promoter suppressing its expression. It was reported that B. abortus induces IFNβ expression in an IRF3-dependent manner, and that mice lacking the IFNα/β receptor are more resistant to Brucella infection.Instituto de PatobiologíaFil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Rossi, Ursula Amaranta. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaFil: Maurizio, Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Maurizio, Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaFil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; ArgentinaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; ArgentinaFil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Rossetti, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaUniversidad Nacional del Centro de la Provincia de Buenos Aires2025-07-15T12:54:51Z2025-07-15T12:54:51Z2023-08info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/20.500.12123/23026II Congreso de Microbiología Veterinaria, Facultad de Ciencias Veterinarias, Universidad del Centro de la Provincia de Buenos Aires, 9 al 12 de agosto 2023reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:32:24Zoai:localhost:20.500.12123/23026instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:32:24.584INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
title An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
spellingShingle An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
Rossi, Ursula Amaranta
Brucella melitensis
Macrófago
Caprinae
Caprinos
Interferona
Citoquina
Respuesta Inmunológica
Organismo patógeno
Macrophages
Goats
Interferons
Cytokines
Immune Response
Pathogens
title_short An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
title_full An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
title_fullStr An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
title_full_unstemmed An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
title_sort An insertion in the caprine IRF3 gene affects macrophage response to B. melitensis infection
dc.creator.none.fl_str_mv Rossi, Ursula Amaranta
Maurizio, Estefanía
Caffaro, María Eugenia
Poli, Mario Andres
Rossetti, Carlos Alberto
author Rossi, Ursula Amaranta
author_facet Rossi, Ursula Amaranta
Maurizio, Estefanía
Caffaro, María Eugenia
Poli, Mario Andres
Rossetti, Carlos Alberto
author_role author
author2 Maurizio, Estefanía
Caffaro, María Eugenia
Poli, Mario Andres
Rossetti, Carlos Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv Brucella melitensis
Macrófago
Caprinae
Caprinos
Interferona
Citoquina
Respuesta Inmunológica
Organismo patógeno
Macrophages
Goats
Interferons
Cytokines
Immune Response
Pathogens
topic Brucella melitensis
Macrófago
Caprinae
Caprinos
Interferona
Citoquina
Respuesta Inmunológica
Organismo patógeno
Macrophages
Goats
Interferons
Cytokines
Immune Response
Pathogens
dc.description.none.fl_txt_mv Poster
Brucella melitensis is the etiological agent of brucellosis in goats and the main cause of human brucellosis. Interferons (IFNs) are important cytokines in the immune responses to intracellular pathogens and tumor cells. Although IFNβ is classically associated with antiviral responses, growing evidence shows that IFNβ is also involved in the cellular response to bacterial infections. IRF3 is a member of the interferon regulatory transcription factor family that plays a critical role in both the early and late phases of the IFNα/β gene induction. In general, it is considered that IRF3 acts as a suppressor of pro-inflammatory genes and an enhancer of anti inflammatory genes. For example, IRF3 can be directly recruited to the IL12B promoter suppressing its expression. It was reported that B. abortus induces IFNβ expression in an IRF3-dependent manner, and that mice lacking the IFNα/β receptor are more resistant to Brucella infection.
Instituto de Patobiología
Fil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Rossi, Ursula Amaranta. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Maurizio, Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Maurizio, Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Caffaro, María Eugenia. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; Argentina
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria, (INTA). Instituto de Genética “Ewald A. Favret”; Argentina
Fil: Rossetti, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Rossetti, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
description Poster
publishDate 2023
dc.date.none.fl_str_mv 2023-08
2025-07-15T12:54:51Z
2025-07-15T12:54:51Z
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/23026
url http://hdl.handle.net/20.500.12123/23026
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional del Centro de la Provincia de Buenos Aires
publisher.none.fl_str_mv Universidad Nacional del Centro de la Provincia de Buenos Aires
dc.source.none.fl_str_mv II Congreso de Microbiología Veterinaria, Facultad de Ciencias Veterinarias, Universidad del Centro de la Provincia de Buenos Aires, 9 al 12 de agosto 2023
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.712165

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