Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus

Autores
Miro, Maria Victoria; Sarli, Macarena; Rossner, Maria Victoria; Gomez, Viviana Daniela; Toffaletti, Jose Rodolfo; Lifschitz, Adrian Luis; Nava, Santiago
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus (Boophilus) microplus. The trial was performed in two populations of R. (B.) microplus with different levels of susceptibility to ivermectin: San Martín (SM) (incipient resistance) and Colonia Benítez (CB) (susceptible). Twenty-one (SM) and forty-two (CB) 12-month-old Braford heifers, naturally infested with R. (B.) microplus, were individually weighed and divided into three groups (G). G1 and G2 were treated with a dose of ivermectin 3.15% (IVOMEC GOLD®) at a dose rate of 630 μg/kg of body weight (1 mL/50 kg). G1 received a uniform dose of ivermectin calculated according to the average of the individual body weights. G2 received a dose of ivermectin calculated according to the exact body weight of each animal. G3 were the control group. Ivermectin concentrations were measured from blood samples from day 1 to day 21 post-treatment. The efficacy of the treatment was evaluated by counting female ticks. In both populations the differences in the doses of ivermectin administered did not affect the pharmacokinetics and therapeutic efficacy of the drug. Nevertheless, it is necessary to avoid the sub-dosage of cattle to reduce the selection pressure for resistance on the tick populations.
EEA Rafaela
Fil: Miró, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Sarli, Macarena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Sarli, Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Rossner, Maria Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina
Fil: Gomez, Viviana Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina
Fil: Toffaletti, Jose Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria El Colorado; Argentina
Fil: Lifschitz, Adrian Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fuente
Systematic and Applied Acarology 27 (9) : 1800-1812. (2022)
Materia
Rhipicephalus
Boophilus microplus
Peso Corporal
Estimación
Ganado Bovino
Ivermectina
Body Weight
Valuation
Cattle
Ivermectin
Garrapatas
Ticks
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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oai_identifier_str oai:localhost:20.500.12123/12882
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplusMiro, Maria VictoriaSarli, MacarenaRossner, Maria VictoriaGomez, Viviana DanielaToffaletti, Jose RodolfoLifschitz, Adrian LuisNava, SantiagoRhipicephalusBoophilus microplusPeso CorporalEstimaciónGanado BovinoIvermectinaBody WeightValuationCattleIvermectinGarrapatasTicksThis study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus (Boophilus) microplus. The trial was performed in two populations of R. (B.) microplus with different levels of susceptibility to ivermectin: San Martín (SM) (incipient resistance) and Colonia Benítez (CB) (susceptible). Twenty-one (SM) and forty-two (CB) 12-month-old Braford heifers, naturally infested with R. (B.) microplus, were individually weighed and divided into three groups (G). G1 and G2 were treated with a dose of ivermectin 3.15% (IVOMEC GOLD®) at a dose rate of 630 μg/kg of body weight (1 mL/50 kg). G1 received a uniform dose of ivermectin calculated according to the average of the individual body weights. G2 received a dose of ivermectin calculated according to the exact body weight of each animal. G3 were the control group. Ivermectin concentrations were measured from blood samples from day 1 to day 21 post-treatment. The efficacy of the treatment was evaluated by counting female ticks. In both populations the differences in the doses of ivermectin administered did not affect the pharmacokinetics and therapeutic efficacy of the drug. Nevertheless, it is necessary to avoid the sub-dosage of cattle to reduce the selection pressure for resistance on the tick populations.EEA RafaelaFil: Miró, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.Fil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.Fil: Sarli, Macarena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Sarli, Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Rossner, Maria Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; ArgentinaFil: Gomez, Viviana Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; ArgentinaFil: Toffaletti, Jose Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria El Colorado; ArgentinaFil: Lifschitz, Adrian Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaFil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); ArgentinaSystematic and Applied Acarology Society2022-09-14T15:38:04Z2022-09-14T15:38:04Z2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12882https://www.biotaxa.org/saa/article/view/747891362-1971 (Print)2056-6069 (Online)https://doi.org/10.11158/saa.27.9.9Systematic and Applied Acarology 27 (9) : 1800-1812. (2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PE-E5-I109-001/2019-PE-E5-I109-001/AR./Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y lainfo:eu-repo/semantics/restrictedAccess2025-09-04T09:49:34Zoai:localhost:20.500.12123/12882instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:49:34.369INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
title Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
spellingShingle Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
Miro, Maria Victoria
Rhipicephalus
Boophilus microplus
Peso Corporal
Estimación
Ganado Bovino
Ivermectina
Body Weight
Valuation
Cattle
Ivermectin
Garrapatas
Ticks
title_short Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
title_full Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
title_fullStr Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
title_full_unstemmed Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
title_sort Influence of the cattle body weight estimation for drug dosing on the pharmacokinetic and efficacy of ivermectin against Rhipicephalus (Boophilus) microplus
dc.creator.none.fl_str_mv Miro, Maria Victoria
Sarli, Macarena
Rossner, Maria Victoria
Gomez, Viviana Daniela
Toffaletti, Jose Rodolfo
Lifschitz, Adrian Luis
Nava, Santiago
author Miro, Maria Victoria
author_facet Miro, Maria Victoria
Sarli, Macarena
Rossner, Maria Victoria
Gomez, Viviana Daniela
Toffaletti, Jose Rodolfo
Lifschitz, Adrian Luis
Nava, Santiago
author_role author
author2 Sarli, Macarena
Rossner, Maria Victoria
Gomez, Viviana Daniela
Toffaletti, Jose Rodolfo
Lifschitz, Adrian Luis
Nava, Santiago
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Rhipicephalus
Boophilus microplus
Peso Corporal
Estimación
Ganado Bovino
Ivermectina
Body Weight
Valuation
Cattle
Ivermectin
Garrapatas
Ticks
topic Rhipicephalus
Boophilus microplus
Peso Corporal
Estimación
Ganado Bovino
Ivermectina
Body Weight
Valuation
Cattle
Ivermectin
Garrapatas
Ticks
dc.description.none.fl_txt_mv This study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus (Boophilus) microplus. The trial was performed in two populations of R. (B.) microplus with different levels of susceptibility to ivermectin: San Martín (SM) (incipient resistance) and Colonia Benítez (CB) (susceptible). Twenty-one (SM) and forty-two (CB) 12-month-old Braford heifers, naturally infested with R. (B.) microplus, were individually weighed and divided into three groups (G). G1 and G2 were treated with a dose of ivermectin 3.15% (IVOMEC GOLD®) at a dose rate of 630 μg/kg of body weight (1 mL/50 kg). G1 received a uniform dose of ivermectin calculated according to the average of the individual body weights. G2 received a dose of ivermectin calculated according to the exact body weight of each animal. G3 were the control group. Ivermectin concentrations were measured from blood samples from day 1 to day 21 post-treatment. The efficacy of the treatment was evaluated by counting female ticks. In both populations the differences in the doses of ivermectin administered did not affect the pharmacokinetics and therapeutic efficacy of the drug. Nevertheless, it is necessary to avoid the sub-dosage of cattle to reduce the selection pressure for resistance on the tick populations.
EEA Rafaela
Fil: Miró, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Sarli, Macarena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Sarli, Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Rossner, Maria Victoria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina
Fil: Gomez, Viviana Daniela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Colonia Benitez; Argentina
Fil: Toffaletti, Jose Rodolfo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria El Colorado; Argentina
Fil: Lifschitz, Adrian Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación Veterinaria de Tandil. Laboratorio de Farmacología; Argentina.
Fil: Nava, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Rafaela. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
Fil: Nava, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigación de la Cadena Láctea (IDICAL); Argentina
description This study aimed to evaluate how the method of body weight estimation of a herd (average vs individual) for drug dosing may affect the pharmacokinetics and therapeutic efficacy of ivermectin 3.15% against Rhipicephalus (Boophilus) microplus. The trial was performed in two populations of R. (B.) microplus with different levels of susceptibility to ivermectin: San Martín (SM) (incipient resistance) and Colonia Benítez (CB) (susceptible). Twenty-one (SM) and forty-two (CB) 12-month-old Braford heifers, naturally infested with R. (B.) microplus, were individually weighed and divided into three groups (G). G1 and G2 were treated with a dose of ivermectin 3.15% (IVOMEC GOLD®) at a dose rate of 630 μg/kg of body weight (1 mL/50 kg). G1 received a uniform dose of ivermectin calculated according to the average of the individual body weights. G2 received a dose of ivermectin calculated according to the exact body weight of each animal. G3 were the control group. Ivermectin concentrations were measured from blood samples from day 1 to day 21 post-treatment. The efficacy of the treatment was evaluated by counting female ticks. In both populations the differences in the doses of ivermectin administered did not affect the pharmacokinetics and therapeutic efficacy of the drug. Nevertheless, it is necessary to avoid the sub-dosage of cattle to reduce the selection pressure for resistance on the tick populations.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-14T15:38:04Z
2022-09-14T15:38:04Z
2022-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/12882
https://www.biotaxa.org/saa/article/view/74789
1362-1971 (Print)
2056-6069 (Online)
https://doi.org/10.11158/saa.27.9.9
url http://hdl.handle.net/20.500.12123/12882
https://www.biotaxa.org/saa/article/view/74789
https://doi.org/10.11158/saa.27.9.9
identifier_str_mv 1362-1971 (Print)
2056-6069 (Online)
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001/2019-PE-E5-I109-001/AR./Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Systematic and Applied Acarology Society
publisher.none.fl_str_mv Systematic and Applied Acarology Society
dc.source.none.fl_str_mv Systematic and Applied Acarology 27 (9) : 1800-1812. (2022)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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