Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations

Autores
Camargo, Luana; Franklin, Yasmin Vieira; da Silva, Gustavo Feliciano Resende; Santos, Janaína Ferreira; Parreño, Gladys Viviana; Wigdorovitz, Andres; Gomes, Viviani
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infection and transmission. We evaluated the serological immune response against BoAHV-1 induced by eight different formulations of commercial vaccines: three modified live vaccines and five killed vaccines containing BoAHV type 1 or types 1 and 5. In the first experiment, 50 BoAHV-1-seronegative guinea pigs were assigned to eight groups; each individual in the treatment groups received two doses (one-fifth of the bovine dose). The second experiment was conducted using 29 crossbred Holstein × Gir heifers in four groups of six to nine animals each. The serological immune response against BoAHV-1 was measured using virus neutralization and enzyme-linked immunosorbent assays to measure the total IgG against BoAHV. We evaluated the effects of the vaccine, time, and interaction of the vaccine and time on neutralizing antibodies against BoAHV-1. Killed vaccines produced low levels of antibodies against BoAHV-1, whereas modified live vaccines produced high levels of antibodies capable of providing neutralizing titers in the vaccinated animals, with the thermosensitive modified live vaccine showing the highest levels of antibodies.
Instituto de Virología
Fil: Camargo, Luana. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fil: Franklin, Yasmin Vieira. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fil: da Silva, Gustavo Feliciano Resende. Universidade Federal de Goiânia. Department of Animal Production; Brasil
Fil: Santos, Janaína Ferreira. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina
Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas (IVIT); Argentina
Fil: Gomes, Viviani. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fuente
Vaccines 12 (6) : 615 (Junio 2024)
Materia
Vaccination
Dairy Cattle
Vaccines
Antibodies
Guinea Pigs
Heifers
Vacunación
Ganado de Leche
Vacuna
Anticuerpos
Cobaya
Novilla
Bovine alphaherpesvirus 1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/18294
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oai_identifier_str oai:localhost:20.500.12123/18294
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network_name_str INTA Digital (INTA)
spelling Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulationsCamargo, LuanaFranklin, Yasmin Vieirada Silva, Gustavo Feliciano ResendeSantos, Janaína FerreiraParreño, Gladys VivianaWigdorovitz, AndresGomes, VivianiVaccinationDairy CattleVaccinesAntibodiesGuinea PigsHeifersVacunaciónGanado de LecheVacunaAnticuerposCobayaNovillaBovine alphaherpesvirus 1Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infection and transmission. We evaluated the serological immune response against BoAHV-1 induced by eight different formulations of commercial vaccines: three modified live vaccines and five killed vaccines containing BoAHV type 1 or types 1 and 5. In the first experiment, 50 BoAHV-1-seronegative guinea pigs were assigned to eight groups; each individual in the treatment groups received two doses (one-fifth of the bovine dose). The second experiment was conducted using 29 crossbred Holstein × Gir heifers in four groups of six to nine animals each. The serological immune response against BoAHV-1 was measured using virus neutralization and enzyme-linked immunosorbent assays to measure the total IgG against BoAHV. We evaluated the effects of the vaccine, time, and interaction of the vaccine and time on neutralizing antibodies against BoAHV-1. Killed vaccines produced low levels of antibodies against BoAHV-1, whereas modified live vaccines produced high levels of antibodies capable of providing neutralizing titers in the vaccinated animals, with the thermosensitive modified live vaccine showing the highest levels of antibodies.Instituto de VirologíaFil: Camargo, Luana. Universidade de São Paulo. Department of Medical Clinic; BrasilFil: Franklin, Yasmin Vieira. Universidade de São Paulo. Department of Medical Clinic; BrasilFil: da Silva, Gustavo Feliciano Resende. Universidade Federal de Goiânia. Department of Animal Production; BrasilFil: Santos, Janaína Ferreira. Universidade de São Paulo. Department of Medical Clinic; BrasilFil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia e Innovaciones Tecnologicas (IVIT); ArgentinaFil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas (IVIT); ArgentinaFil: Gomes, Viviani. Universidade de São Paulo. Department of Medical Clinic; BrasilMDPI2024-06-28T10:55:49Z2024-06-28T10:55:49Z2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/18294https://www.mdpi.com/2076-393X/12/6/6152076-393Xhttps://doi.org/10.3390/vaccines12060615Vaccines 12 (6) : 615 (Junio 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:50:28Zoai:localhost:20.500.12123/18294instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:50:28.577INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
title Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
spellingShingle Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
Camargo, Luana
Vaccination
Dairy Cattle
Vaccines
Antibodies
Guinea Pigs
Heifers
Vacunación
Ganado de Leche
Vacuna
Anticuerpos
Cobaya
Novilla
Bovine alphaherpesvirus 1
title_short Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
title_full Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
title_fullStr Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
title_full_unstemmed Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
title_sort Serological responses of Guinea pigs and heifers to eight different BoAHV-1 vaccine formulations
dc.creator.none.fl_str_mv Camargo, Luana
Franklin, Yasmin Vieira
da Silva, Gustavo Feliciano Resende
Santos, Janaína Ferreira
Parreño, Gladys Viviana
Wigdorovitz, Andres
Gomes, Viviani
author Camargo, Luana
author_facet Camargo, Luana
Franklin, Yasmin Vieira
da Silva, Gustavo Feliciano Resende
Santos, Janaína Ferreira
Parreño, Gladys Viviana
Wigdorovitz, Andres
Gomes, Viviani
author_role author
author2 Franklin, Yasmin Vieira
da Silva, Gustavo Feliciano Resende
Santos, Janaína Ferreira
Parreño, Gladys Viviana
Wigdorovitz, Andres
Gomes, Viviani
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Vaccination
Dairy Cattle
Vaccines
Antibodies
Guinea Pigs
Heifers
Vacunación
Ganado de Leche
Vacuna
Anticuerpos
Cobaya
Novilla
Bovine alphaherpesvirus 1
topic Vaccination
Dairy Cattle
Vaccines
Antibodies
Guinea Pigs
Heifers
Vacunación
Ganado de Leche
Vacuna
Anticuerpos
Cobaya
Novilla
Bovine alphaherpesvirus 1
dc.description.none.fl_txt_mv Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infection and transmission. We evaluated the serological immune response against BoAHV-1 induced by eight different formulations of commercial vaccines: three modified live vaccines and five killed vaccines containing BoAHV type 1 or types 1 and 5. In the first experiment, 50 BoAHV-1-seronegative guinea pigs were assigned to eight groups; each individual in the treatment groups received two doses (one-fifth of the bovine dose). The second experiment was conducted using 29 crossbred Holstein × Gir heifers in four groups of six to nine animals each. The serological immune response against BoAHV-1 was measured using virus neutralization and enzyme-linked immunosorbent assays to measure the total IgG against BoAHV. We evaluated the effects of the vaccine, time, and interaction of the vaccine and time on neutralizing antibodies against BoAHV-1. Killed vaccines produced low levels of antibodies against BoAHV-1, whereas modified live vaccines produced high levels of antibodies capable of providing neutralizing titers in the vaccinated animals, with the thermosensitive modified live vaccine showing the highest levels of antibodies.
Instituto de Virología
Fil: Camargo, Luana. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fil: Franklin, Yasmin Vieira. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fil: da Silva, Gustavo Feliciano Resende. Universidade Federal de Goiânia. Department of Animal Production; Brasil
Fil: Santos, Janaína Ferreira. Universidade de São Paulo. Department of Medical Clinic; Brasil
Fil: Parreño, Gladys Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virologia e Innovaciones Tecnologicas (IVIT); Argentina
Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas (IVIT); Argentina
Fil: Gomes, Viviani. Universidade de São Paulo. Department of Medical Clinic; Brasil
description Bovine alphaherpesvirus 1 (BoAHV-1) infection affects the production and reproductive performance of dairy and beef livestock, resulting in considerable economic losses. In addition to biosecurity measures, vaccination programs are effective strategies for controlling and preventing BoAHV-1 infection and transmission. We evaluated the serological immune response against BoAHV-1 induced by eight different formulations of commercial vaccines: three modified live vaccines and five killed vaccines containing BoAHV type 1 or types 1 and 5. In the first experiment, 50 BoAHV-1-seronegative guinea pigs were assigned to eight groups; each individual in the treatment groups received two doses (one-fifth of the bovine dose). The second experiment was conducted using 29 crossbred Holstein × Gir heifers in four groups of six to nine animals each. The serological immune response against BoAHV-1 was measured using virus neutralization and enzyme-linked immunosorbent assays to measure the total IgG against BoAHV. We evaluated the effects of the vaccine, time, and interaction of the vaccine and time on neutralizing antibodies against BoAHV-1. Killed vaccines produced low levels of antibodies against BoAHV-1, whereas modified live vaccines produced high levels of antibodies capable of providing neutralizing titers in the vaccinated animals, with the thermosensitive modified live vaccine showing the highest levels of antibodies.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-28T10:55:49Z
2024-06-28T10:55:49Z
2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/18294
https://www.mdpi.com/2076-393X/12/6/615
2076-393X
https://doi.org/10.3390/vaccines12060615
url http://hdl.handle.net/20.500.12123/18294
https://www.mdpi.com/2076-393X/12/6/615
https://doi.org/10.3390/vaccines12060615
identifier_str_mv 2076-393X
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Vaccines 12 (6) : 615 (Junio 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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