Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment

Autores
Odeon, Maria Mercedes; Acosta, Gabriela Beatriz
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression. However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors.
Estación Experimental Agropecuaria Bariloche
Fil: Odeon, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientıicas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina
Fil: Acosta, Gabriela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Progress in Neuropsychopharmacology & Biological Psychiatry 95 : 109726 (2019)
Materia
Respuesta a la Selección
Estrés de Frío
Tolerancia al Frío
Corticosterona
Selection Responses
Cold Stress
Cold Tolerance
Corticosterone
Paramétros de Comportamiento
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/7628
Acceder
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oai_identifier_str oai:localhost:20.500.12123/7628
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network_name_str INTA Digital (INTA)
spelling Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatmentOdeon, Maria MercedesAcosta, Gabriela BeatrizRespuesta a la SelecciónEstrés de FríoTolerancia al FríoCorticosteronaSelection ResponsesCold StressCold ToleranceCorticosteroneParamétros de ComportamientoAdverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression. However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors.Estación Experimental Agropecuaria BarilocheFil: Odeon, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientıicas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; ArgentinaFil: Acosta, Gabriela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2020-07-28T16:38:09Z2020-07-28T16:38:09Z2019-12-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/7628https://www.sciencedirect.com/science/article/abs/pii/S027858461930497X0278-5846https://doi.org/10.1016/j.pnpbp.2019.109726Progress in Neuropsychopharmacology & Biological Psychiatry 95 : 109726 (2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-23T11:17:20Zoai:localhost:20.500.12123/7628instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-23 11:17:20.899INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
title Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
spellingShingle Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
Odeon, Maria Mercedes
Respuesta a la Selección
Estrés de Frío
Tolerancia al Frío
Corticosterona
Selection Responses
Cold Stress
Cold Tolerance
Corticosterone
Paramétros de Comportamiento
title_short Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
title_full Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
title_fullStr Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
title_full_unstemmed Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
title_sort Repeated maternal separation: Alcohol consumption, anxious behavior and corticosterone were reversed by a non-pharmacological treatment
dc.creator.none.fl_str_mv Odeon, Maria Mercedes
Acosta, Gabriela Beatriz
author Odeon, Maria Mercedes
author_facet Odeon, Maria Mercedes
Acosta, Gabriela Beatriz
author_role author
author2 Acosta, Gabriela Beatriz
author2_role author
dc.subject.none.fl_str_mv Respuesta a la Selección
Estrés de Frío
Tolerancia al Frío
Corticosterona
Selection Responses
Cold Stress
Cold Tolerance
Corticosterone
Paramétros de Comportamiento
topic Respuesta a la Selección
Estrés de Frío
Tolerancia al Frío
Corticosterona
Selection Responses
Cold Stress
Cold Tolerance
Corticosterone
Paramétros de Comportamiento
dc.description.none.fl_txt_mv Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression. However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors.
Estación Experimental Agropecuaria Bariloche
Fil: Odeon, Maria Mercedes. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Consejo Nacional de Investigaciones Cientıicas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina
Fil: Acosta, Gabriela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Adverse events in early life have been related to a maladaptive stress response during adulthood, which could predispose individuals to psychiatric and physiological disorders. The purpose of this work was to study the implications of repeated maternal separation (RMS) plus a physical stressor (cold stress), voluntary ethanol consumption and plasmatic levels of corticosterone (Cor) via conflict behavior tests. To this aim, pups were separated daily from their mothers for one hour and subjected to cold stress (4 °C) between postnatal days (PD) 2 and 20. Control groups were left undisturbed with their mothers. Afterwards, all groups were exposed to voluntary ethanol (6%) or dextrose (1%) intake for 7 days. After a 30-day period of environmental enrichment (EE), the animals were again exposed to the voluntary intake protocol for 7 days. At 66 days, they were subjected to different conflict tests. Thereafter, rats were sacrificed by decapitation and blood trunk was collected to determine plasma corticosterone levels. We demonstrated that early RMS increased both voluntary alcohol intake and Cor levels. Moreover, young adult animals showed excessive activity in conflict tests. Whereas in animals exposed to a non-pharmacological treatment, known as environmental enrichment (EE), the effects previously obtained were reversed and/or prevented. In summary, we can conclude that the combination of maternal separation in early life plus cold stress increase both the voluntary exposure to alcohol and disruptive behaviors. This is a risk factor for the development of chronic diseases such as alcoholism and long-term depression. However, we found that an enriched environment may have a beneficial effect with respect to alcohol intake and aggressive behaviors.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-29
2020-07-28T16:38:09Z
2020-07-28T16:38:09Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/7628
https://www.sciencedirect.com/science/article/abs/pii/S027858461930497X
0278-5846
https://doi.org/10.1016/j.pnpbp.2019.109726
url http://hdl.handle.net/20.500.12123/7628
https://www.sciencedirect.com/science/article/abs/pii/S027858461930497X
https://doi.org/10.1016/j.pnpbp.2019.109726
identifier_str_mv 0278-5846
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Progress in Neuropsychopharmacology & Biological Psychiatry 95 : 109726 (2019)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.982451

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