BLV: lessons on vaccine development

Autores
Abdala, Alejandro Ariel; Alvarez, Irene; Brossel, Hélène; Calvinho, Luis Fernando; Carignano, Hugo; Franco, Lautaro Nahuel; Gazon, Hélène; Gillissen, Christelle; Hamaidia, Malik; Hoyos, Clotilde; Jacques, Jean-Rock; Joris, Thomas; Laval, Florent; Petersen, Marcos Iván; Porquet, Florent; Porta, Natalia Gabriela; Ruiz, Vanesa; Safari, Rogaiyeh; Suarez Archilla, Guillermo Alejandro; Trono, Karina Gabriela; Willems, Luc
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.
EEA Rafaela
Fil: Abdala, Alejandro Ariel. INTA. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Alvarez, Irene. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Brossel, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Calvinho, Luis Fernando. INTA. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Carignano, Hugo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Franco, Lautaro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Gillissen, Christelle. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Hoyos, Clotilde. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Joris, Thomas. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Laval, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Petersen, Marcos Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Porquet, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Porta, Natalia Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Safari, Rogaiyeh. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Suarez Archilla, Guillermo Alejandro. INTA. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fuente
Retrovirology 16 : article number: 26 (2019)
Materia
Vacuna
Vacunación
Retroviridae
Virus Leucemia Bovina
Vaccines
Vaccination
Bovine Leukaemia Virus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/6118
Acceder
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oai_identifier_str oai:localhost:20.500.12123/6118
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling BLV: lessons on vaccine developmentAbdala, Alejandro ArielAlvarez, IreneBrossel, HélèneCalvinho, Luis FernandoCarignano, HugoFranco, Lautaro NahuelGazon, HélèneGillissen, ChristelleHamaidia, MalikHoyos, ClotildeJacques, Jean-RockJoris, ThomasLaval, FlorentPetersen, Marcos IvánPorquet, FlorentPorta, Natalia GabrielaRuiz, VanesaSafari, RogaiyehSuarez Archilla, Guillermo AlejandroTrono, Karina GabrielaWillems, LucVacunaVacunaciónRetroviridaeVirus Leucemia BovinaVaccinesVaccinationBovine Leukaemia VirusVaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.EEA RafaelaFil: Abdala, Alejandro Ariel. INTA. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Alvarez, Irene. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Brossel, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Calvinho, Luis Fernando. INTA. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Carignano, Hugo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Franco, Lautaro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Gillissen, Christelle. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Hoyos, Clotilde. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Joris, Thomas. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Laval, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Petersen, Marcos Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Porquet, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Porta, Natalia Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; ArgentinaFil: Safari, Rogaiyeh. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaFil: Suarez Archilla, Guillermo Alejandro. INTA. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); BélgicaBMC2019-10-16T11:40:42Z2019-10-16T11:40:42Z2019-10-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0488-8http://hdl.handle.net/20.500.12123/61181742-4690https://doi.org/10.1186/s12977-019-0488-8Retrovirology 16 : article number: 26 (2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:48:13Zoai:localhost:20.500.12123/6118instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:48:13.45INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv BLV: lessons on vaccine development
title BLV: lessons on vaccine development
spellingShingle BLV: lessons on vaccine development
Abdala, Alejandro Ariel
Vacuna
Vacunación
Retroviridae
Virus Leucemia Bovina
Vaccines
Vaccination
Bovine Leukaemia Virus
title_short BLV: lessons on vaccine development
title_full BLV: lessons on vaccine development
title_fullStr BLV: lessons on vaccine development
title_full_unstemmed BLV: lessons on vaccine development
title_sort BLV: lessons on vaccine development
dc.creator.none.fl_str_mv Abdala, Alejandro Ariel
Alvarez, Irene
Brossel, Hélène
Calvinho, Luis Fernando
Carignano, Hugo
Franco, Lautaro Nahuel
Gazon, Hélène
Gillissen, Christelle
Hamaidia, Malik
Hoyos, Clotilde
Jacques, Jean-Rock
Joris, Thomas
Laval, Florent
Petersen, Marcos Iván
Porquet, Florent
Porta, Natalia Gabriela
Ruiz, Vanesa
Safari, Rogaiyeh
Suarez Archilla, Guillermo Alejandro
Trono, Karina Gabriela
Willems, Luc
author Abdala, Alejandro Ariel
author_facet Abdala, Alejandro Ariel
Alvarez, Irene
Brossel, Hélène
Calvinho, Luis Fernando
Carignano, Hugo
Franco, Lautaro Nahuel
Gazon, Hélène
Gillissen, Christelle
Hamaidia, Malik
Hoyos, Clotilde
Jacques, Jean-Rock
Joris, Thomas
Laval, Florent
Petersen, Marcos Iván
Porquet, Florent
Porta, Natalia Gabriela
Ruiz, Vanesa
Safari, Rogaiyeh
Suarez Archilla, Guillermo Alejandro
Trono, Karina Gabriela
Willems, Luc
author_role author
author2 Alvarez, Irene
Brossel, Hélène
Calvinho, Luis Fernando
Carignano, Hugo
Franco, Lautaro Nahuel
Gazon, Hélène
Gillissen, Christelle
Hamaidia, Malik
Hoyos, Clotilde
Jacques, Jean-Rock
Joris, Thomas
Laval, Florent
Petersen, Marcos Iván
Porquet, Florent
Porta, Natalia Gabriela
Ruiz, Vanesa
Safari, Rogaiyeh
Suarez Archilla, Guillermo Alejandro
Trono, Karina Gabriela
Willems, Luc
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Vacuna
Vacunación
Retroviridae
Virus Leucemia Bovina
Vaccines
Vaccination
Bovine Leukaemia Virus
topic Vacuna
Vacunación
Retroviridae
Virus Leucemia Bovina
Vaccines
Vaccination
Bovine Leukaemia Virus
dc.description.none.fl_txt_mv Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.
EEA Rafaela
Fil: Abdala, Alejandro Ariel. INTA. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Alvarez, Irene. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Brossel, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Calvinho, Luis Fernando. INTA. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Carignano, Hugo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Franco, Lautaro. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Gillissen, Christelle. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Hoyos, Clotilde. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Joris, Thomas. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Laval, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Petersen, Marcos Iván. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Porquet, Florent. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Porta, Natalia Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Ruiz, Vanesa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Safari, Rogaiyeh. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
Fil: Suarez Archilla, Guillermo Alejandro. INTA. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA); Bélgica
description Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response. Since clearance of the virus is almost impossible once infection is established, the primary goal is to achieve sterilizing immunity. Besides efficacy, safety is the major issue since vaccination has been associated with increased infection or reversion to pathogenicity. In this review, we discuss the different issues that we faced during the development of an efficient vaccine against bovine leukemia virus (BLV). We summarize the historical failures of inactivated vaccines, the efficacy and safety of a live-attenuated vaccine and the economical constraints of further industrial development.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-16T11:40:42Z
2019-10-16T11:40:42Z
2019-10-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0488-8
http://hdl.handle.net/20.500.12123/6118
1742-4690
https://doi.org/10.1186/s12977-019-0488-8
url https://retrovirology.biomedcentral.com/articles/10.1186/s12977-019-0488-8
http://hdl.handle.net/20.500.12123/6118
https://doi.org/10.1186/s12977-019-0488-8
identifier_str_mv 1742-4690
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Retrovirology 16 : article number: 26 (2019)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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