Recent advances in BLV research

Autores
Barez, Pierre-Yves; De Brogniez, Alix; Carpentier, Alexandre; Gazon, Hélène; Gillet, Nicolas; Gutierrez, Gerónimo; Hamaidia, Malik; Jacques, Jean-Rock; Perike, Srikanth; Sriramareddy, Sathya Neelature; Renotte, Nathalie; Staumont, Bernard; Reichert, Michal; Trono, Karina Gabriela; Willems, Luc
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.
Instituto de Virología
Fil: Barez, Pierre-Yves. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: de Brogniez, Alix. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Carpentier, Alexandre. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Gillet, Nicolas. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Perike, Srikanth. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Sriramareddy, Sathya Neelature. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Staumont, Bernard. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Reichert, Michal. National Veterinary Research Institute; Polonia
Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fuente
Viruses 7 (11) : 6080-6088 (November 2015)
Materia
Enfermedades de los Animales
Virus Leucemia Bovina
Respuesta Inmunológica
Ganado Bovino
Vacuna
Animal Diseases
Bovine Leukaemia Virus
Immune Response
Cattle
Vaccines
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/5307
Acceder
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oai_identifier_str oai:localhost:20.500.12123/5307
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Recent advances in BLV researchBarez, Pierre-YvesDe Brogniez, AlixCarpentier, AlexandreGazon, HélèneGillet, NicolasGutierrez, GerónimoHamaidia, MalikJacques, Jean-RockPerike, SrikanthSriramareddy, Sathya NeelatureRenotte, NathalieStaumont, BernardReichert, MichalTrono, Karina GabrielaWillems, LucEnfermedades de los AnimalesVirus Leucemia BovinaRespuesta InmunológicaGanado BovinoVacunaAnimal DiseasesBovine Leukaemia VirusImmune ResponseCattleVaccinesDifferent animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.Instituto de VirologíaFil: Barez, Pierre-Yves. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: de Brogniez, Alix. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Carpentier, Alexandre. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Gillet, Nicolas. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Perike, Srikanth. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Sriramareddy, Sathya Neelature. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Staumont, Bernard. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaFil: Reichert, Michal. National Veterinary Research Institute; PoloniaFil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; BélgicaMDPI2019-06-13T12:09:52Z2019-06-13T12:09:52Z2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.mdpi.com/1999-4915/7/11/2929http://hdl.handle.net/20.500.12123/53071999-4915https://doi.org/10.3390/v7112929Viruses 7 (11) : 6080-6088 (November 2015)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-18T10:07:35Zoai:localhost:20.500.12123/5307instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-18 10:07:36.309INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Recent advances in BLV research
title Recent advances in BLV research
spellingShingle Recent advances in BLV research
Barez, Pierre-Yves
Enfermedades de los Animales
Virus Leucemia Bovina
Respuesta Inmunológica
Ganado Bovino
Vacuna
Animal Diseases
Bovine Leukaemia Virus
Immune Response
Cattle
Vaccines
title_short Recent advances in BLV research
title_full Recent advances in BLV research
title_fullStr Recent advances in BLV research
title_full_unstemmed Recent advances in BLV research
title_sort Recent advances in BLV research
dc.creator.none.fl_str_mv Barez, Pierre-Yves
De Brogniez, Alix
Carpentier, Alexandre
Gazon, Hélène
Gillet, Nicolas
Gutierrez, Gerónimo
Hamaidia, Malik
Jacques, Jean-Rock
Perike, Srikanth
Sriramareddy, Sathya Neelature
Renotte, Nathalie
Staumont, Bernard
Reichert, Michal
Trono, Karina Gabriela
Willems, Luc
author Barez, Pierre-Yves
author_facet Barez, Pierre-Yves
De Brogniez, Alix
Carpentier, Alexandre
Gazon, Hélène
Gillet, Nicolas
Gutierrez, Gerónimo
Hamaidia, Malik
Jacques, Jean-Rock
Perike, Srikanth
Sriramareddy, Sathya Neelature
Renotte, Nathalie
Staumont, Bernard
Reichert, Michal
Trono, Karina Gabriela
Willems, Luc
author_role author
author2 De Brogniez, Alix
Carpentier, Alexandre
Gazon, Hélène
Gillet, Nicolas
Gutierrez, Gerónimo
Hamaidia, Malik
Jacques, Jean-Rock
Perike, Srikanth
Sriramareddy, Sathya Neelature
Renotte, Nathalie
Staumont, Bernard
Reichert, Michal
Trono, Karina Gabriela
Willems, Luc
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedades de los Animales
Virus Leucemia Bovina
Respuesta Inmunológica
Ganado Bovino
Vacuna
Animal Diseases
Bovine Leukaemia Virus
Immune Response
Cattle
Vaccines
topic Enfermedades de los Animales
Virus Leucemia Bovina
Respuesta Inmunológica
Ganado Bovino
Vacuna
Animal Diseases
Bovine Leukaemia Virus
Immune Response
Cattle
Vaccines
dc.description.none.fl_txt_mv Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.
Instituto de Virología
Fil: Barez, Pierre-Yves. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: de Brogniez, Alix. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Carpentier, Alexandre. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Gazon, Hélène. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Gillet, Nicolas. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Gutierrez, Gerónimo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Hamaidia, Malik. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Jacques, Jean-Rock. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Perike, Srikanth. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Sriramareddy, Sathya Neelature. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Renotte, Nathalie. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Staumont, Bernard. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
Fil: Reichert, Michal. National Veterinary Research Institute; Polonia
Fil: Trono, Karina Gabriela. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Willems, Luc. University of Liège. Molecular and Cellular Epigenetics; Bélgica. University of Liège. Molecular and Cellular Biology, Gembloux Agro-Bio Tech; Bélgica
description Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
2019-06-13T12:09:52Z
2019-06-13T12:09:52Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.mdpi.com/1999-4915/7/11/2929
http://hdl.handle.net/20.500.12123/5307
1999-4915
https://doi.org/10.3390/v7112929
url https://www.mdpi.com/1999-4915/7/11/2929
http://hdl.handle.net/20.500.12123/5307
https://doi.org/10.3390/v7112929
identifier_str_mv 1999-4915
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Viruses 7 (11) : 6080-6088 (November 2015)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 13.001348

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