The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus

Autores
Caspe, Sergio Gaston; Palarea-Albaladejo, Javier; Livingstone, Morag; Wattegedera, Sean Ranjan; Milne, Elspeth; Sargison, Neil Donald; Longbottom, David
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases, such as ovine enzootic abortion (OEA), impact on foetal viability due to the reduction in the functional area for maternofoetal exchange. This study aimed to consider the impact of pathological features of OEA placental lesions on lamb birth weight and indirectly on foetal viability. To investigate the relationship between birth weight and various OEA-related parameters, data from 562 lambs/foetuses from animals experimentally challenged with Chlamydia abortus strain S26/3 and from uninfected animals were analysed. The parameters investigated included the number of foetuses/lambs delivered (single/multiple), foetus/lamb sex, length of gestation, the proportion of placentas affected by lesions (percentage of gross placental pathology), foetal viability (live/aborted) and the number of C. abortus organisms shed in post-parturition vaginal excretions. The results suggest that the length of gestation and the proportion of placentas affected by lesions are the main contributors to birth weight variability, whereas the other factors, including foetal viability (live or aborted outcomes), were found to be less relevant co-variables. The study determined the strongest positive and negative correlations between birth weight were with the length of gestation and the extent of placental pathology, respectively. These results may indicate that economic losses associated with OEA infections result not only from aborted foetuses but also from the surviving lambs that are born weaker and consequently are more susceptible to diseases.
EEA Mercedes
Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido
Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Palarea-Albaladejo, Javier. University of Girona. Deparment of Computer Sciences, Applied Mathematics and Statistics; España
Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido
Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido
Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Longbottom, David. Moredun Research Institute; Reino Unido
Fuente
Small Ruminant Research : 107029 (Available online 28 June 2023)
Materia
Chlamydophila abortus
Ewes
Birth Weight
Placenta
Animal Diseases
Abortion
Oveja
Peso al Nacimiento
Enfermedades de los Animales
Aborto
Chlamydia abortus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/14679
Acceder
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oai_identifier_str oai:localhost:20.500.12123/14679
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortusCaspe, Sergio GastonPalarea-Albaladejo, JavierLivingstone, MoragWattegedera, Sean RanjanMilne, ElspethSargison, Neil DonaldLongbottom, DavidChlamydophila abortusEwesBirth WeightPlacentaAnimal DiseasesAbortionOvejaPeso al NacimientoEnfermedades de los AnimalesAbortoChlamydia abortusThe placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases, such as ovine enzootic abortion (OEA), impact on foetal viability due to the reduction in the functional area for maternofoetal exchange. This study aimed to consider the impact of pathological features of OEA placental lesions on lamb birth weight and indirectly on foetal viability. To investigate the relationship between birth weight and various OEA-related parameters, data from 562 lambs/foetuses from animals experimentally challenged with Chlamydia abortus strain S26/3 and from uninfected animals were analysed. The parameters investigated included the number of foetuses/lambs delivered (single/multiple), foetus/lamb sex, length of gestation, the proportion of placentas affected by lesions (percentage of gross placental pathology), foetal viability (live/aborted) and the number of C. abortus organisms shed in post-parturition vaginal excretions. The results suggest that the length of gestation and the proportion of placentas affected by lesions are the main contributors to birth weight variability, whereas the other factors, including foetal viability (live or aborted outcomes), were found to be less relevant co-variables. The study determined the strongest positive and negative correlations between birth weight were with the length of gestation and the extent of placental pathology, respectively. These results may indicate that economic losses associated with OEA infections result not only from aborted foetuses but also from the surviving lambs that are born weaker and consequently are more susceptible to diseases.EEA MercedesFil: Caspe, Sergio Gaston. Moredun Research Institute; Reino UnidoFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino UnidoFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino UnidoFil: Palarea-Albaladejo, Javier. University of Girona. Deparment of Computer Sciences, Applied Mathematics and Statistics; EspañaFil: Livingstone, Morag. Moredun Research Institute; Reino UnidoFil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino UnidoFil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino UnidoFil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino UnidoFil: Longbottom, David. Moredun Research Institute; Reino UnidoElsevier2023-07-03T10:39:41Z2023-07-03T10:39:41Z2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/14679https://www.sciencedirect.com/science/article/pii/S09214488230012560921-44881879-0941https://doi.org/10.1016/j.smallrumres.2023.107029Small Ruminant Research : 107029 (Available online 28 June 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-29T13:45:59Zoai:localhost:20.500.12123/14679instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:45:59.972INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
title The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
spellingShingle The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
Caspe, Sergio Gaston
Chlamydophila abortus
Ewes
Birth Weight
Placenta
Animal Diseases
Abortion
Oveja
Peso al Nacimiento
Enfermedades de los Animales
Aborto
Chlamydia abortus
title_short The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
title_full The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
title_fullStr The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
title_full_unstemmed The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
title_sort The extent of placental pathology is negatively correlated to birth weight in ewes infected with the wild-type strain of Chlamydia abortus
dc.creator.none.fl_str_mv Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Livingstone, Morag
Wattegedera, Sean Ranjan
Milne, Elspeth
Sargison, Neil Donald
Longbottom, David
author Caspe, Sergio Gaston
author_facet Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Livingstone, Morag
Wattegedera, Sean Ranjan
Milne, Elspeth
Sargison, Neil Donald
Longbottom, David
author_role author
author2 Palarea-Albaladejo, Javier
Livingstone, Morag
Wattegedera, Sean Ranjan
Milne, Elspeth
Sargison, Neil Donald
Longbottom, David
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Chlamydophila abortus
Ewes
Birth Weight
Placenta
Animal Diseases
Abortion
Oveja
Peso al Nacimiento
Enfermedades de los Animales
Aborto
Chlamydia abortus
topic Chlamydophila abortus
Ewes
Birth Weight
Placenta
Animal Diseases
Abortion
Oveja
Peso al Nacimiento
Enfermedades de los Animales
Aborto
Chlamydia abortus
dc.description.none.fl_txt_mv The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases, such as ovine enzootic abortion (OEA), impact on foetal viability due to the reduction in the functional area for maternofoetal exchange. This study aimed to consider the impact of pathological features of OEA placental lesions on lamb birth weight and indirectly on foetal viability. To investigate the relationship between birth weight and various OEA-related parameters, data from 562 lambs/foetuses from animals experimentally challenged with Chlamydia abortus strain S26/3 and from uninfected animals were analysed. The parameters investigated included the number of foetuses/lambs delivered (single/multiple), foetus/lamb sex, length of gestation, the proportion of placentas affected by lesions (percentage of gross placental pathology), foetal viability (live/aborted) and the number of C. abortus organisms shed in post-parturition vaginal excretions. The results suggest that the length of gestation and the proportion of placentas affected by lesions are the main contributors to birth weight variability, whereas the other factors, including foetal viability (live or aborted outcomes), were found to be less relevant co-variables. The study determined the strongest positive and negative correlations between birth weight were with the length of gestation and the extent of placental pathology, respectively. These results may indicate that economic losses associated with OEA infections result not only from aborted foetuses but also from the surviving lambs that are born weaker and consequently are more susceptible to diseases.
EEA Mercedes
Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido
Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Palarea-Albaladejo, Javier. University of Girona. Deparment of Computer Sciences, Applied Mathematics and Statistics; España
Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido
Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido
Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Longbottom, David. Moredun Research Institute; Reino Unido
description The placenta is the organ that allows the exchange of oxygen and nutrients between maternal and foetal blood, supplying the requirements of the growing foetus. Consequently, any factor that alters placental integrity may affect foetal nutrition, viability and lamb birth weight. Reproductive diseases, such as ovine enzootic abortion (OEA), impact on foetal viability due to the reduction in the functional area for maternofoetal exchange. This study aimed to consider the impact of pathological features of OEA placental lesions on lamb birth weight and indirectly on foetal viability. To investigate the relationship between birth weight and various OEA-related parameters, data from 562 lambs/foetuses from animals experimentally challenged with Chlamydia abortus strain S26/3 and from uninfected animals were analysed. The parameters investigated included the number of foetuses/lambs delivered (single/multiple), foetus/lamb sex, length of gestation, the proportion of placentas affected by lesions (percentage of gross placental pathology), foetal viability (live/aborted) and the number of C. abortus organisms shed in post-parturition vaginal excretions. The results suggest that the length of gestation and the proportion of placentas affected by lesions are the main contributors to birth weight variability, whereas the other factors, including foetal viability (live or aborted outcomes), were found to be less relevant co-variables. The study determined the strongest positive and negative correlations between birth weight were with the length of gestation and the extent of placental pathology, respectively. These results may indicate that economic losses associated with OEA infections result not only from aborted foetuses but also from the surviving lambs that are born weaker and consequently are more susceptible to diseases.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-03T10:39:41Z
2023-07-03T10:39:41Z
2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/14679
https://www.sciencedirect.com/science/article/pii/S0921448823001256
0921-4488
1879-0941
https://doi.org/10.1016/j.smallrumres.2023.107029
url http://hdl.handle.net/20.500.12123/14679
https://www.sciencedirect.com/science/article/pii/S0921448823001256
https://doi.org/10.1016/j.smallrumres.2023.107029
identifier_str_mv 0921-4488
1879-0941
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Small Ruminant Research : 107029 (Available online 28 June 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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