Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes

Autores
Caspe, Sergio Gaston; Palarea-Albaladejo, Javier; Underwood, Clare; Livingstone, Morag; Wattegedera, Sean Ranjan; Milne, Elspeth; Sargison, Neil Donald; Chianini, Francesca; Longbottom, David
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens.
EEA Mercedes
Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido
Fil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Underwood, Clare. Moredun Research Institute; Reino Unido
Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido
Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido
Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
Fil: Longbottom, David. Moredun Research Institute; Reino Unido
Fuente
Pathogens 10 (5) : 543 (April 2021)
Materia
Oveja
Enfermedades de los Animales
Chlamydophila abortus
Vacuna
Placenta
Chlamydia
Control de Enfermedades
Ewes
Animal Diseases
Vaccines
Diseases Control
Chlamydia abortus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/9561
Acceder
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oai_identifier_str oai:localhost:20.500.12123/9561
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spelling Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated EwesCaspe, Sergio GastonPalarea-Albaladejo, JavierUnderwood, ClareLivingstone, MoragWattegedera, Sean RanjanMilne, ElspethSargison, Neil DonaldChianini, FrancescaLongbottom, DavidOvejaEnfermedades de los AnimalesChlamydophila abortusVacunaPlacentaChlamydiaControl de EnfermedadesEwesAnimal DiseasesVaccinesDiseases ControlChlamydia abortusChlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens.EEA MercedesFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Caspe, Sergio Gaston. Moredun Research Institute; Reino UnidoFil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino UnidoFil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino UnidoFil: Underwood, Clare. Moredun Research Institute; Reino UnidoFil: Livingstone, Morag. Moredun Research Institute; Reino UnidoFil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino UnidoFil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino UnidoFil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino UnidoFil: Chianini, Francesca. Moredun Research Institute; Reino UnidoFil: Longbottom, David. Moredun Research Institute; Reino UnidoMDPI2021-06-11T11:59:10Z2021-06-11T11:59:10Z2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/9561https://www.mdpi.com/2076-0817/10/5/5432076-0817https://doi.org/10.3390/pathogens10050543Pathogens 10 (5) : 543 (April 2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:30:07Zoai:localhost:20.500.12123/9561instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:30:07.845INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
title Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
spellingShingle Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
Caspe, Sergio Gaston
Oveja
Enfermedades de los Animales
Chlamydophila abortus
Vacuna
Placenta
Chlamydia
Control de Enfermedades
Ewes
Animal Diseases
Vaccines
Diseases Control
Chlamydia abortus
title_short Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
title_full Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
title_fullStr Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
title_full_unstemmed Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
title_sort Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
dc.creator.none.fl_str_mv Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Underwood, Clare
Livingstone, Morag
Wattegedera, Sean Ranjan
Milne, Elspeth
Sargison, Neil Donald
Chianini, Francesca
Longbottom, David
author Caspe, Sergio Gaston
author_facet Caspe, Sergio Gaston
Palarea-Albaladejo, Javier
Underwood, Clare
Livingstone, Morag
Wattegedera, Sean Ranjan
Milne, Elspeth
Sargison, Neil Donald
Chianini, Francesca
Longbottom, David
author_role author
author2 Palarea-Albaladejo, Javier
Underwood, Clare
Livingstone, Morag
Wattegedera, Sean Ranjan
Milne, Elspeth
Sargison, Neil Donald
Chianini, Francesca
Longbottom, David
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oveja
Enfermedades de los Animales
Chlamydophila abortus
Vacuna
Placenta
Chlamydia
Control de Enfermedades
Ewes
Animal Diseases
Vaccines
Diseases Control
Chlamydia abortus
topic Oveja
Enfermedades de los Animales
Chlamydophila abortus
Vacuna
Placenta
Chlamydia
Control de Enfermedades
Ewes
Animal Diseases
Vaccines
Diseases Control
Chlamydia abortus
dc.description.none.fl_txt_mv Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens.
EEA Mercedes
Fil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Caspe, Sergio Gaston. Moredun Research Institute; Reino Unido
Fil: Caspe, Sergio Gaston. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Underwood, Clare. Moredun Research Institute; Reino Unido
Fil: Livingstone, Morag. Moredun Research Institute; Reino Unido
Fil: Wattegedera, Sean Ranjan. Moredun Research Institute; Reino Unido
Fil: Milne, Elspeth. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Sargison, Neil Donald. University of Edinburgh. Royal (Dick) School of Veterinary Studies; Reino Unido
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
Fil: Longbottom, David. Moredun Research Institute; Reino Unido
description Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-11T11:59:10Z
2021-06-11T11:59:10Z
2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/9561
https://www.mdpi.com/2076-0817/10/5/543
2076-0817
https://doi.org/10.3390/pathogens10050543
url http://hdl.handle.net/20.500.12123/9561
https://www.mdpi.com/2076-0817/10/5/543
https://doi.org/10.3390/pathogens10050543
identifier_str_mv 2076-0817
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Pathogens 10 (5) : 543 (April 2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.712165

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