Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens

Autores
Joaquim, Patricia Estefania; Balbiani, Facundo; Socas, Maria Laura; Morales, Hernando; Casey, Marcos; Rubio, Jesus; Chacana, Pablo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Fowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical signs, and vertical or horizontal transmission. The aim of this work was to assess the protection against FT conferred by vaccines based on Salmonella Enteritidis (SE), SG, or a combination. Five experimental groups of birds, vaccinated with different live or inactivated SG and SE vaccines were included in the trial: 1) two doses of a SG-SE bivalent inactivated vaccine; 2) four doses of the live attenuated SE vaccine; 3) three doses of the live attenuated SE vaccine and two doses of the SG-SE bivalent inactivated vaccine; 4) two doses of the live attenuated SG9R vaccine; and 5) unvaccinated birds. At 28 wk of age, all hens were challenged with a virulent strain of SG, and mortality was recorded during the subsequent 15 days. The results showed that the plan that included only the inactivated vaccine did not show significant protection (P = 1), while the plan based on the administration of the attenuated strain of SE significantly reduced mortality in the group of birds (P = 0.0309). However, the highest levels of protection were obtained in the group of hens immunized with the combination of the inactivated vaccine and the live attenuated SE strain (P < 0.0001), which was statistically similar to the homologous protection conferred by the SG 9R strain, a vaccine used in many countries to control FT. These results demonstrate that the combination of existing vaccines together with strict biosecurity measures on farms may help improve the control of the pathogen in countries where FT in an emerging or reemerging disease.
Instituto de Patobiología
Fil: Joaquim, Patricia Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Joaquim, Patricia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balbiani, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Balbiani, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Socas, Maria Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Socas, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Morales, Hernando. CALIER; España
Fil: Casey, Marcos. CALIER; España
Fil: Rubio, Jesus. CALIER; España
Fil: Chacana, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Chacana, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Avian Diseases 68 (3) : 259-262 (September 2024)
Materia
Salmonella gallinarum
Tifosis Aviar
Vacuna
Gallina Ponedora
Protección
Fowl Typhoid
Vaccines
Layer Chickens
Protection
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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Acceder
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oai_identifier_str oai:localhost:20.500.12123/22998
network_acronym_str INTADig
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spelling Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hensJoaquim, Patricia EstefaniaBalbiani, FacundoSocas, Maria LauraMorales, HernandoCasey, MarcosRubio, JesusChacana, PabloSalmonella gallinarumTifosis AviarVacunaGallina PonedoraProtecciónFowl TyphoidVaccinesLayer ChickensProtectionFowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical signs, and vertical or horizontal transmission. The aim of this work was to assess the protection against FT conferred by vaccines based on Salmonella Enteritidis (SE), SG, or a combination. Five experimental groups of birds, vaccinated with different live or inactivated SG and SE vaccines were included in the trial: 1) two doses of a SG-SE bivalent inactivated vaccine; 2) four doses of the live attenuated SE vaccine; 3) three doses of the live attenuated SE vaccine and two doses of the SG-SE bivalent inactivated vaccine; 4) two doses of the live attenuated SG9R vaccine; and 5) unvaccinated birds. At 28 wk of age, all hens were challenged with a virulent strain of SG, and mortality was recorded during the subsequent 15 days. The results showed that the plan that included only the inactivated vaccine did not show significant protection (P = 1), while the plan based on the administration of the attenuated strain of SE significantly reduced mortality in the group of birds (P = 0.0309). However, the highest levels of protection were obtained in the group of hens immunized with the combination of the inactivated vaccine and the live attenuated SE strain (P < 0.0001), which was statistically similar to the homologous protection conferred by the SG 9R strain, a vaccine used in many countries to control FT. These results demonstrate that the combination of existing vaccines together with strict biosecurity measures on farms may help improve the control of the pathogen in countries where FT in an emerging or reemerging disease.Instituto de PatobiologíaFil: Joaquim, Patricia Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Joaquim, Patricia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balbiani, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Balbiani, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Socas, Maria Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Socas, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Morales, Hernando. CALIER; EspañaFil: Casey, Marcos. CALIER; EspañaFil: Rubio, Jesus. CALIER; EspañaFil: Chacana, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Chacana, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Association of Avian Pathologists2025-07-11T14:47:48Z2025-07-11T14:47:48Z2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/22998https://bioone.org/journals/avian-diseases/volume-68/issue-3/aviandiseases-D-24-00024/Combination-of-Live-and-Inactivated-Salmonella-Vaccines-to-Protect-Against/10.1637/aviandiseases-D-24-00024.short0005-20861938-4351https://doi.org/10.1637/aviandiseases-D-24-00024Avian Diseases 68 (3) : 259-262 (September 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:51:10Zoai:localhost:20.500.12123/22998instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:51:11.044INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
title Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
spellingShingle Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
Joaquim, Patricia Estefania
Salmonella gallinarum
Tifosis Aviar
Vacuna
Gallina Ponedora
Protección
Fowl Typhoid
Vaccines
Layer Chickens
Protection
title_short Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
title_full Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
title_fullStr Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
title_full_unstemmed Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
title_sort Combination of live and inactivated salmonella vaccines to protect against fowl typhoid in laying hens
dc.creator.none.fl_str_mv Joaquim, Patricia Estefania
Balbiani, Facundo
Socas, Maria Laura
Morales, Hernando
Casey, Marcos
Rubio, Jesus
Chacana, Pablo
author Joaquim, Patricia Estefania
author_facet Joaquim, Patricia Estefania
Balbiani, Facundo
Socas, Maria Laura
Morales, Hernando
Casey, Marcos
Rubio, Jesus
Chacana, Pablo
author_role author
author2 Balbiani, Facundo
Socas, Maria Laura
Morales, Hernando
Casey, Marcos
Rubio, Jesus
Chacana, Pablo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Salmonella gallinarum
Tifosis Aviar
Vacuna
Gallina Ponedora
Protección
Fowl Typhoid
Vaccines
Layer Chickens
Protection
topic Salmonella gallinarum
Tifosis Aviar
Vacuna
Gallina Ponedora
Protección
Fowl Typhoid
Vaccines
Layer Chickens
Protection
dc.description.none.fl_txt_mv Fowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical signs, and vertical or horizontal transmission. The aim of this work was to assess the protection against FT conferred by vaccines based on Salmonella Enteritidis (SE), SG, or a combination. Five experimental groups of birds, vaccinated with different live or inactivated SG and SE vaccines were included in the trial: 1) two doses of a SG-SE bivalent inactivated vaccine; 2) four doses of the live attenuated SE vaccine; 3) three doses of the live attenuated SE vaccine and two doses of the SG-SE bivalent inactivated vaccine; 4) two doses of the live attenuated SG9R vaccine; and 5) unvaccinated birds. At 28 wk of age, all hens were challenged with a virulent strain of SG, and mortality was recorded during the subsequent 15 days. The results showed that the plan that included only the inactivated vaccine did not show significant protection (P = 1), while the plan based on the administration of the attenuated strain of SE significantly reduced mortality in the group of birds (P = 0.0309). However, the highest levels of protection were obtained in the group of hens immunized with the combination of the inactivated vaccine and the live attenuated SE strain (P < 0.0001), which was statistically similar to the homologous protection conferred by the SG 9R strain, a vaccine used in many countries to control FT. These results demonstrate that the combination of existing vaccines together with strict biosecurity measures on farms may help improve the control of the pathogen in countries where FT in an emerging or reemerging disease.
Instituto de Patobiología
Fil: Joaquim, Patricia Estefania. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Joaquim, Patricia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Balbiani, Facundo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Balbiani, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Socas, Maria Laura. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Socas, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Morales, Hernando. CALIER; España
Fil: Casey, Marcos. CALIER; España
Fil: Rubio, Jesus. CALIER; España
Fil: Chacana, Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Chacana, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Fowl typhoid (FT) caused by Salmonella Gallinarum (SG) is a poultry disease distributed worldwide that has been eradicated in commercial production of many developed countries but still persists in many developing countries. Vaccination is one of the main strategies to reduce mortality, clinical signs, and vertical or horizontal transmission. The aim of this work was to assess the protection against FT conferred by vaccines based on Salmonella Enteritidis (SE), SG, or a combination. Five experimental groups of birds, vaccinated with different live or inactivated SG and SE vaccines were included in the trial: 1) two doses of a SG-SE bivalent inactivated vaccine; 2) four doses of the live attenuated SE vaccine; 3) three doses of the live attenuated SE vaccine and two doses of the SG-SE bivalent inactivated vaccine; 4) two doses of the live attenuated SG9R vaccine; and 5) unvaccinated birds. At 28 wk of age, all hens were challenged with a virulent strain of SG, and mortality was recorded during the subsequent 15 days. The results showed that the plan that included only the inactivated vaccine did not show significant protection (P = 1), while the plan based on the administration of the attenuated strain of SE significantly reduced mortality in the group of birds (P = 0.0309). However, the highest levels of protection were obtained in the group of hens immunized with the combination of the inactivated vaccine and the live attenuated SE strain (P < 0.0001), which was statistically similar to the homologous protection conferred by the SG 9R strain, a vaccine used in many countries to control FT. These results demonstrate that the combination of existing vaccines together with strict biosecurity measures on farms may help improve the control of the pathogen in countries where FT in an emerging or reemerging disease.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
2025-07-11T14:47:48Z
2025-07-11T14:47:48Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/22998
https://bioone.org/journals/avian-diseases/volume-68/issue-3/aviandiseases-D-24-00024/Combination-of-Live-and-Inactivated-Salmonella-Vaccines-to-Protect-Against/10.1637/aviandiseases-D-24-00024.short
0005-2086
1938-4351
https://doi.org/10.1637/aviandiseases-D-24-00024
url http://hdl.handle.net/20.500.12123/22998
https://bioone.org/journals/avian-diseases/volume-68/issue-3/aviandiseases-D-24-00024/Combination-of-Live-and-Inactivated-Salmonella-Vaccines-to-Protect-Against/10.1637/aviandiseases-D-24-00024.short
https://doi.org/10.1637/aviandiseases-D-24-00024
identifier_str_mv 0005-2086
1938-4351
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Association of Avian Pathologists
publisher.none.fl_str_mv American Association of Avian Pathologists
dc.source.none.fl_str_mv Avian Diseases 68 (3) : 259-262 (September 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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