Tuberculosis vaccine candidates based on mycobacterial cell envelope components

Autores
Sarmiento, María E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado Hernández, Yanely; García, M.A.; Anis, F.Z.; Norazmi, Mohd Nor; Acosta, Armando
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
Instituto de Biotecnología
Fil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados Unidos
Fil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; Malasia
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; Cuba
Fil: García, M.A. Instituto Finlay de Vacunas; Cuba
Fil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fuente
Tuberculosis 115 : 26-41. (March 2019)
Materia
Mycobacterium tuberculosis
Vacuna
Pared Celular
Membrana
Tuberculosis
Vaccines
Cell Walls
Membranes
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/4520
Acceder
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spelling Tuberculosis vaccine candidates based on mycobacterial cell envelope componentsSarmiento, María E.Alvarez, N.Chin, K.L.Bigi, FabianaTirado Hernández, YanelyGarcía, M.A.Anis, F.Z.Norazmi, Mohd NorAcosta, ArmandoMycobacterium tuberculosisVacunaPared CelularMembranaTuberculosisVaccinesCell WallsMembranesEven after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.Instituto de BiotecnologíaFil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; MalasiaFil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados UnidosFil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; MalasiaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; CubaFil: García, M.A. Instituto Finlay de Vacunas; CubaFil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; MalasiaFil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; MalasiaFil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; MalasiaElsevier2019-02-28T16:47:34Z2019-02-28T16:47:34Z2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/4520https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub1472-9792https://doi.org/10.1016/j.tube.2019.01.003Tuberculosis 115 : 26-41. (March 2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-10-16T09:29:27Zoai:localhost:20.500.12123/4520instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:29:27.919INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title Tuberculosis vaccine candidates based on mycobacterial cell envelope components
spellingShingle Tuberculosis vaccine candidates based on mycobacterial cell envelope components
Sarmiento, María E.
Mycobacterium tuberculosis
Vacuna
Pared Celular
Membrana
Tuberculosis
Vaccines
Cell Walls
Membranes
title_short Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_full Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_fullStr Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_full_unstemmed Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_sort Tuberculosis vaccine candidates based on mycobacterial cell envelope components
dc.creator.none.fl_str_mv Sarmiento, María E.
Alvarez, N.
Chin, K.L.
Bigi, Fabiana
Tirado Hernández, Yanely
García, M.A.
Anis, F.Z.
Norazmi, Mohd Nor
Acosta, Armando
author Sarmiento, María E.
author_facet Sarmiento, María E.
Alvarez, N.
Chin, K.L.
Bigi, Fabiana
Tirado Hernández, Yanely
García, M.A.
Anis, F.Z.
Norazmi, Mohd Nor
Acosta, Armando
author_role author
author2 Alvarez, N.
Chin, K.L.
Bigi, Fabiana
Tirado Hernández, Yanely
García, M.A.
Anis, F.Z.
Norazmi, Mohd Nor
Acosta, Armando
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mycobacterium tuberculosis
Vacuna
Pared Celular
Membrana
Tuberculosis
Vaccines
Cell Walls
Membranes
topic Mycobacterium tuberculosis
Vacuna
Pared Celular
Membrana
Tuberculosis
Vaccines
Cell Walls
Membranes
dc.description.none.fl_txt_mv Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
Instituto de Biotecnología
Fil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados Unidos
Fil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; Malasia
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; Cuba
Fil: García, M.A. Instituto Finlay de Vacunas; Cuba
Fil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; Malasia
description Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-28T16:47:34Z
2019-02-28T16:47:34Z
2019-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/4520
https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub
1472-9792
https://doi.org/10.1016/j.tube.2019.01.003
url http://hdl.handle.net/20.500.12123/4520
https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub
https://doi.org/10.1016/j.tube.2019.01.003
identifier_str_mv 1472-9792
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Tuberculosis 115 : 26-41. (March 2019)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.712165

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