Tuberculosis vaccine candidates based on mycobacterial cell envelope components
- Autores
- Sarmiento, María E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado Hernández, Yanely; García, M.A.; Anis, F.Z.; Norazmi, Mohd Nor; Acosta, Armando
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
Instituto de Biotecnología
Fil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados Unidos
Fil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; Malasia
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; Cuba
Fil: García, M.A. Instituto Finlay de Vacunas; Cuba
Fil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; Malasia
Fil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; Malasia - Fuente
- Tuberculosis 115 : 26-41. (March 2019)
- Materia
-
Mycobacterium tuberculosis
Vacuna
Pared Celular
Membrana
Tuberculosis
Vaccines
Cell Walls
Membranes - Nivel de accesibilidad
- acceso restringido
- Condiciones de uso
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/4520
Ver los metadatos del registro completo
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Tuberculosis vaccine candidates based on mycobacterial cell envelope componentsSarmiento, María E.Alvarez, N.Chin, K.L.Bigi, FabianaTirado Hernández, YanelyGarcía, M.A.Anis, F.Z.Norazmi, Mohd NorAcosta, ArmandoMycobacterium tuberculosisVacunaPared CelularMembranaTuberculosisVaccinesCell WallsMembranesEven after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.Instituto de BiotecnologíaFil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; MalasiaFil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados UnidosFil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; MalasiaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; ArgentinaFil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; CubaFil: García, M.A. Instituto Finlay de Vacunas; CubaFil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; MalasiaFil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; MalasiaFil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; MalasiaElsevier2019-02-28T16:47:34Z2019-02-28T16:47:34Z2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/4520https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub1472-9792https://doi.org/10.1016/j.tube.2019.01.003Tuberculosis 115 : 26-41. (March 2019)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccess2025-09-29T13:44:35Zoai:localhost:20.500.12123/4520instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-29 13:44:35.715INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
title |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
spellingShingle |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components Sarmiento, María E. Mycobacterium tuberculosis Vacuna Pared Celular Membrana Tuberculosis Vaccines Cell Walls Membranes |
title_short |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
title_full |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
title_fullStr |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
title_full_unstemmed |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
title_sort |
Tuberculosis vaccine candidates based on mycobacterial cell envelope components |
dc.creator.none.fl_str_mv |
Sarmiento, María E. Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando |
author |
Sarmiento, María E. |
author_facet |
Sarmiento, María E. Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando |
author_role |
author |
author2 |
Alvarez, N. Chin, K.L. Bigi, Fabiana Tirado Hernández, Yanely García, M.A. Anis, F.Z. Norazmi, Mohd Nor Acosta, Armando |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Mycobacterium tuberculosis Vacuna Pared Celular Membrana Tuberculosis Vaccines Cell Walls Membranes |
topic |
Mycobacterium tuberculosis Vacuna Pared Celular Membrana Tuberculosis Vaccines Cell Walls Membranes |
dc.description.none.fl_txt_mv |
Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb. Instituto de Biotecnología Fil: Sarmiento, María E. Universiti Sains Malaysia. School of Health Sciences; Malasia Fil: Alvarez, N. Public Health Research Institute. Rutgers New Jersey Medical School; Estados Unidos Fil: Chin, K.L. Universiti Malaysia Sabah. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences and Therapeutic; Malasia Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina Fil: Tirado Hernández, Yanely. Instituto Finlay de Vacunas; Cuba Fil: García, M.A. Instituto Finlay de Vacunas; Cuba Fil: Anis, F.Z. Universiti Sains Malaysia. School of Health Sciences; Malasia Fil: Norazmi, Mohd Nor. Universiti Sains Malaysia. School of Health Sciences; Malasia Fil: Acosta, Armando. Universiti Sains Malaysia. School of Health Sciences; Malasia |
description |
Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-28T16:47:34Z 2019-02-28T16:47:34Z 2019-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/4520 https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub 1472-9792 https://doi.org/10.1016/j.tube.2019.01.003 |
url |
http://hdl.handle.net/20.500.12123/4520 https://www.sciencedirect.com/science/article/pii/S1472979218304943?via%3Dihub https://doi.org/10.1016/j.tube.2019.01.003 |
identifier_str_mv |
1472-9792 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/restrictedAccess |
eu_rights_str_mv |
restrictedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
Tuberculosis 115 : 26-41. (March 2019) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
collection |
INTA Digital (INTA) |
instname_str |
Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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1844619131054194688 |
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12.559606 |