Tuberculosis vaccine candidates based on mycobacterial cell envelope components

Autores
Sarmiento, M.E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado, Y.; García, M.A.; Anis, F.Z.; Norazmi, M.N.; Acosta, A.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
Fil: Sarmiento, M.E.. Universiti Sains Malaysia; Malasia
Fil: Alvarez, N.. Public Health Research Institute; Estados Unidos
Fil: Chin, K.L.. Universiti Sains Malaysia; Malasia
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Tirado, Y.. No especifíca;
Fil: García, M.A.. No especifíca;
Fil: Anis, F.Z.. Universiti Sains Malaysia; Malasia
Fil: Norazmi, M.N.. Universiti Sains Malaysia; Malasia
Fil: Acosta, A.. Universiti Sains Malaysia; Malasia
Materia
CELL WALL
MEMBRANE
MYCOBACTERIUM TUBERCULOSIS
VACCINES
VESICLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/149159
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/149159
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tuberculosis vaccine candidates based on mycobacterial cell envelope componentsSarmiento, M.E.Alvarez, N.Chin, K.L.Bigi, FabianaTirado, Y.García, M.A.Anis, F.Z.Norazmi, M.N.Acosta, A.CELL WALLMEMBRANEMYCOBACTERIUM TUBERCULOSISVACCINESVESICLEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.Fil: Sarmiento, M.E.. Universiti Sains Malaysia; MalasiaFil: Alvarez, N.. Public Health Research Institute; Estados UnidosFil: Chin, K.L.. Universiti Sains Malaysia; MalasiaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Tirado, Y.. No especifíca;Fil: García, M.A.. No especifíca;Fil: Anis, F.Z.. Universiti Sains Malaysia; MalasiaFil: Norazmi, M.N.. Universiti Sains Malaysia; MalasiaFil: Acosta, A.. Universiti Sains Malaysia; MalasiaChurchill Livingstone2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149159Sarmiento, M.E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado, Y.; et al.; Tuberculosis vaccine candidates based on mycobacterial cell envelope components; Churchill Livingstone; Tuberculosis (Edinb); 115; 3-2019; 26-411472-9792CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1472979218304943info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tube.2019.01.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:03Zoai:ri.conicet.gov.ar:11336/149159instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:04.15CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title Tuberculosis vaccine candidates based on mycobacterial cell envelope components
spellingShingle Tuberculosis vaccine candidates based on mycobacterial cell envelope components
Sarmiento, M.E.
CELL WALL
MEMBRANE
MYCOBACTERIUM TUBERCULOSIS
VACCINES
VESICLES
title_short Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_full Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_fullStr Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_full_unstemmed Tuberculosis vaccine candidates based on mycobacterial cell envelope components
title_sort Tuberculosis vaccine candidates based on mycobacterial cell envelope components
dc.creator.none.fl_str_mv Sarmiento, M.E.
Alvarez, N.
Chin, K.L.
Bigi, Fabiana
Tirado, Y.
García, M.A.
Anis, F.Z.
Norazmi, M.N.
Acosta, A.
author Sarmiento, M.E.
author_facet Sarmiento, M.E.
Alvarez, N.
Chin, K.L.
Bigi, Fabiana
Tirado, Y.
García, M.A.
Anis, F.Z.
Norazmi, M.N.
Acosta, A.
author_role author
author2 Alvarez, N.
Chin, K.L.
Bigi, Fabiana
Tirado, Y.
García, M.A.
Anis, F.Z.
Norazmi, M.N.
Acosta, A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CELL WALL
MEMBRANE
MYCOBACTERIUM TUBERCULOSIS
VACCINES
VESICLES
topic CELL WALL
MEMBRANE
MYCOBACTERIUM TUBERCULOSIS
VACCINES
VESICLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
Fil: Sarmiento, M.E.. Universiti Sains Malaysia; Malasia
Fil: Alvarez, N.. Public Health Research Institute; Estados Unidos
Fil: Chin, K.L.. Universiti Sains Malaysia; Malasia
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Tirado, Y.. No especifíca;
Fil: García, M.A.. No especifíca;
Fil: Anis, F.Z.. Universiti Sains Malaysia; Malasia
Fil: Norazmi, M.N.. Universiti Sains Malaysia; Malasia
Fil: Acosta, A.. Universiti Sains Malaysia; Malasia
description Even after decades searching for a new and more effective vaccine against tuberculosis, the scientific community is still pursuing this goal due to the complexity of its causative agent, Mycobacterium tuberculosis (Mtb). Mtb is a microorganism with a robust variety of survival mechanisms that allow it to remain in the host for years. The structure and nature of the Mtb envelope play a leading role in its resistance and survival. Mtb has a perfect machinery that allows it to modulate the immune response in its favor and to adapt to the host's environmental conditions in order to remain alive until the moment to reactivate its normal growing state. Mtb cell envelope protein, carbohydrate and lipid components have been the subject of interest for developing new vaccines because most of them are responsible for the pathogenicity and virulence of the bacteria. Many indirect evidences, mainly derived from the use of monoclonal antibodies, support the potential protective role of Mtb envelope components. Subunit and DNA vaccines, lipid extracts, liposomes and membrane vesicle formulations are some examples of technologies used, with encouraging results, to evaluate the potential of these antigens in the protective response against Mtb.
publishDate 2019
dc.date.none.fl_str_mv 2019-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149159
Sarmiento, M.E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado, Y.; et al.; Tuberculosis vaccine candidates based on mycobacterial cell envelope components; Churchill Livingstone; Tuberculosis (Edinb); 115; 3-2019; 26-41
1472-9792
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149159
identifier_str_mv Sarmiento, M.E.; Alvarez, N.; Chin, K.L.; Bigi, Fabiana; Tirado, Y.; et al.; Tuberculosis vaccine candidates based on mycobacterial cell envelope components; Churchill Livingstone; Tuberculosis (Edinb); 115; 3-2019; 26-41
1472-9792
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1472979218304943
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tube.2019.01.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Churchill Livingstone
publisher.none.fl_str_mv Churchill Livingstone
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613545482780672
score 13.070432

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