Pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis

• Autores: Bos, Kirsten I.; Harkins, Kelly M.; Herbig, Alexander; Coscolla, Mireia; Weber, Nico; Comas, Iñaki; Forrest, Stephen A.; Bryant, Josephine M.; Harris, Simon R.; Schuenemann, Verena J.; Campbell, Tessa J.; Majander, Kerrtu; Wilbur, Alicia K.; Guichon, Ricardo A.; Steadman, Dawnie L. Wolfe; Cook, Della Collins; Niemann, Stefan; Behr, Marcel A.; Zumarraga, Martin Jose; Bastida, Ricardo; Huson, Daniel; Nieselt, Kay; Young, Douglas; Parkhill, Julian; Buikstra, Jane E.; Gagneux, Sebastien; Stone, Anne C.; Krause, Johannes
• Año de publicación: 2014
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Nature 514 : 494-497 (Agosto 2014)
• Materia: Tuberculosis; Infección Mycobacterium tuberculosis; Genomas; Enfermedades Humanas; Mycobacterium tuberculosis Infections; Genomes; Human Diseases
• Institución: Instituto Nacional de Tecnología Agropecuaria

Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those from Europe, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-old mycobacterial genomes from Peruvian human skeletons, revealing that a member of the M. tuberculosis complex caused human disease before contact. The ancient strains are distinct from known human-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.
Instituto de Biotecnología
Fil: Bos, Kirsten I. University of Tübingen. Department of Archaeological Sciences; Alemania
Fil: Harkins, Kelly M. Arizona State University. School of Human Evolution and Social Change; Estados Unidos
Fil: Herbig, Alexander. University of Tübingen. Department of Archaeological Sciences; Alemania
Fil: Coscolla, Mireia. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suiza
Fil: Weber, Nico. University of Tübingen. Center for Bioinformatics; Alemania
Fil: Comas, Iñaki. FISABIO-Public Health. Genomics and Health Unit; España. Centros de Investigación Biomédica en Red (CIBER) in Epidemiology and Public Health. Instituto de Salud Carlos III; España
Fil: Forrest, Stephen A. University of Tübingen. Department of Archaeological Sciences; Alemania
Fil: Bryant, Josephine M. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido
Fil: Harris, Simon R. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido
Fil: Schuenemann, Verena J. University of Tübingen. Department of Archaeological Sciences; Alemania
Fil: Campbell, Tessa J. University of Cape Town. Department of Archaeology; Sudáfrica
Fil: Majander, Kerrtu. University of Tübingen. Department of Archaeological Sciences; Alemania
Fil: Wilbur, Alicia K. Arizona State University. School of Human Evolution and Social Change; Estados Unidos
Fil: Guichon, Ricardo A. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Steadman, Dawnie L. Wolfe. University of Tennessee. Department of Anthropology; Estados Unidos
Fil: Cook, Della Collins. Indiana University. Department of Anthropology; Estados Unidos
Fil: Niemann, Stefan. Forschungszentrum Borste. Molecular Mycobacteriology; Alemania. Forschungszentrum Borstel. German Center for Infection Research; Alemania
Fil: Behr, Marcel A. McGill University. McGill International TB Centre; Canadá
Fil: Zumarraga, Martin Jose. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología; Argentina
Fil: Bastida, Ricardo. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Huson, Daniel. University of Tübingen. Center for Bioinformatics; Alemania
Fil: Nieselt, Kay. University of Tübingen. Center for Bioinformatics; Alemania
Fil: Young, Douglas. Imperial College. Department of Medicine; Reino Unido. MRC National Institute for Medical Research. Division of Mycobacterial Research; Reino Unido
Fil: Parkhill, Julian. The Wellcome Trust Sanger Institute. Pathogen Genomics; Reino Unido
Fil: Buikstra, Jane E. Arizona State University. School of Human Evolution and Social Change; Estados Unidos
Fil: Gagneux, Sebastien. Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology; Suiza. University of Basel; Suiza
Fil: Stone, Anne C. Arizona State University. School of Human Evolution and Social Change; Estados Unidos
Fil: Krause, Johannes. University of Tübingen. Senckenberg Centre for Human Evolution and Palaeoenvironment; Alemania. Max Planck Institute for Science and History; Alemania