Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis

Autores
Bellido, Demian; Wenz, Diego; Schang, Martin; Rubiolo, Facundo Tibaldo; Mangioni, Pablo; Gumina, Emanuel; Wigdorovitz, Andres; Parreño, Viviana
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: This study evaluated the effect of a novel subunit-targeted vaccine against BVDV in six dairy farms in Argentina. Methods: Reproductive, health, and production parameters—including conception and abortion rates, open days, calves born per insemination, as well as newborn and overall mortality, and milk production—were monitored over a ten-year period (2014–2023). Data were analyzed annually to assess trends and compare the periods before and after vaccine introduction. Results: All parameters showed significant improvement after vaccine incorporation, with an 11% increase in conception rate, a 5% reduction in abortion rate, a 12% increase in calves per insemination rate, and a decrease of 11 open days (8.4%). Additionally, newborn mortality and overall mortality decreased by 33% and 16%, respectively, while milk production increased by 9%. These data were also compared with eight non-vaccinated dairy farms, and significant differences were observed in health and reproductive parameters. Conclusions: These findings indicate that vaccination with an effective non-replicating subunit vaccine can successfully minimize the impact of BVDV in dairy farms.
Instituto de Virología
Fil: Bellido, Demian. Vetanco SA; Argentina
Fil: Bellido, Demian. Bioinnovo SA; Argentina
Fil: Wenz, Diego. Vetanco SA; Argentina
Fil: Schang, Martin. Vetanco SA; Argentina
Fil: Rubiolo, Facundo Tibaldo. Vetanco SA; Argentina
Fil: Mangioni, Pablo. Vetanco SA; Argentina
Fil: Gumina, Emanuel. Vetanco SA; Argentina
Fil: Wigdorovitz, Andres. Bioinnovo S.A.; Argentina
Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina
Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina
Fuente
Vaccines 13 (3) : 319. (March 2025)
Materia
Granjas Lecheras
Vacuna
Diarrea Viral Bovina
Pestivirus de la Diarrea Bovina
Vacunación
Dairy Farms
Vaccines
Bovine Viral Diarrhoea
Bovine Diarrhoea Pestivirus
Vaccination
Tambos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/21725
Acceder
id INTADig_30ff297db1e2c113ef48b64858029bfb
oai_identifier_str oai:localhost:20.500.12123/21725
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal AnalysisBellido, DemianWenz, DiegoSchang, MartinRubiolo, Facundo TibaldoMangioni, PabloGumina, EmanuelWigdorovitz, AndresParreño, VivianaGranjas LecherasVacunaDiarrea Viral BovinaPestivirus de la Diarrea BovinaVacunaciónDairy FarmsVaccinesBovine Viral DiarrhoeaBovine Diarrhoea PestivirusVaccinationTambosObjective: This study evaluated the effect of a novel subunit-targeted vaccine against BVDV in six dairy farms in Argentina. Methods: Reproductive, health, and production parameters—including conception and abortion rates, open days, calves born per insemination, as well as newborn and overall mortality, and milk production—were monitored over a ten-year period (2014–2023). Data were analyzed annually to assess trends and compare the periods before and after vaccine introduction. Results: All parameters showed significant improvement after vaccine incorporation, with an 11% increase in conception rate, a 5% reduction in abortion rate, a 12% increase in calves per insemination rate, and a decrease of 11 open days (8.4%). Additionally, newborn mortality and overall mortality decreased by 33% and 16%, respectively, while milk production increased by 9%. These data were also compared with eight non-vaccinated dairy farms, and significant differences were observed in health and reproductive parameters. Conclusions: These findings indicate that vaccination with an effective non-replicating subunit vaccine can successfully minimize the impact of BVDV in dairy farms.Instituto de VirologíaFil: Bellido, Demian. Vetanco SA; ArgentinaFil: Bellido, Demian. Bioinnovo SA; ArgentinaFil: Wenz, Diego. Vetanco SA; ArgentinaFil: Schang, Martin. Vetanco SA; ArgentinaFil: Rubiolo, Facundo Tibaldo. Vetanco SA; ArgentinaFil: Mangioni, Pablo. Vetanco SA; ArgentinaFil: Gumina, Emanuel. Vetanco SA; ArgentinaFil: Wigdorovitz, Andres. Bioinnovo S.A.; ArgentinaFil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; ArgentinaFil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; ArgentinaMDPI2025-03-19T11:46:57Z2025-03-19T11:46:57Z2025-03-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/21725https://www.mdpi.com/2076-393X/13/3/3192076-393Xhttps://doi.org/10.3390/vaccines13030319Vaccines 13 (3) : 319. (March 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:32:13Zoai:localhost:20.500.12123/21725instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:32:13.68INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
title Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
spellingShingle Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
Bellido, Demian
Granjas Lecheras
Vacuna
Diarrea Viral Bovina
Pestivirus de la Diarrea Bovina
Vacunación
Dairy Farms
Vaccines
Bovine Viral Diarrhoea
Bovine Diarrhoea Pestivirus
Vaccination
Tambos
title_short Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
title_full Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
title_fullStr Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
title_full_unstemmed Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
title_sort Impact of the Implementation of a Bovine Viral Diarrhea Virus Targeted Vaccine in Dairy Farms: Longitudinal Analysis
dc.creator.none.fl_str_mv Bellido, Demian
Wenz, Diego
Schang, Martin
Rubiolo, Facundo Tibaldo
Mangioni, Pablo
Gumina, Emanuel
Wigdorovitz, Andres
Parreño, Viviana
author Bellido, Demian
author_facet Bellido, Demian
Wenz, Diego
Schang, Martin
Rubiolo, Facundo Tibaldo
Mangioni, Pablo
Gumina, Emanuel
Wigdorovitz, Andres
Parreño, Viviana
author_role author
author2 Wenz, Diego
Schang, Martin
Rubiolo, Facundo Tibaldo
Mangioni, Pablo
Gumina, Emanuel
Wigdorovitz, Andres
Parreño, Viviana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Granjas Lecheras
Vacuna
Diarrea Viral Bovina
Pestivirus de la Diarrea Bovina
Vacunación
Dairy Farms
Vaccines
Bovine Viral Diarrhoea
Bovine Diarrhoea Pestivirus
Vaccination
Tambos
topic Granjas Lecheras
Vacuna
Diarrea Viral Bovina
Pestivirus de la Diarrea Bovina
Vacunación
Dairy Farms
Vaccines
Bovine Viral Diarrhoea
Bovine Diarrhoea Pestivirus
Vaccination
Tambos
dc.description.none.fl_txt_mv Objective: This study evaluated the effect of a novel subunit-targeted vaccine against BVDV in six dairy farms in Argentina. Methods: Reproductive, health, and production parameters—including conception and abortion rates, open days, calves born per insemination, as well as newborn and overall mortality, and milk production—were monitored over a ten-year period (2014–2023). Data were analyzed annually to assess trends and compare the periods before and after vaccine introduction. Results: All parameters showed significant improvement after vaccine incorporation, with an 11% increase in conception rate, a 5% reduction in abortion rate, a 12% increase in calves per insemination rate, and a decrease of 11 open days (8.4%). Additionally, newborn mortality and overall mortality decreased by 33% and 16%, respectively, while milk production increased by 9%. These data were also compared with eight non-vaccinated dairy farms, and significant differences were observed in health and reproductive parameters. Conclusions: These findings indicate that vaccination with an effective non-replicating subunit vaccine can successfully minimize the impact of BVDV in dairy farms.
Instituto de Virología
Fil: Bellido, Demian. Vetanco SA; Argentina
Fil: Bellido, Demian. Bioinnovo SA; Argentina
Fil: Wenz, Diego. Vetanco SA; Argentina
Fil: Schang, Martin. Vetanco SA; Argentina
Fil: Rubiolo, Facundo Tibaldo. Vetanco SA; Argentina
Fil: Mangioni, Pablo. Vetanco SA; Argentina
Fil: Gumina, Emanuel. Vetanco SA; Argentina
Fil: Wigdorovitz, Andres. Bioinnovo S.A.; Argentina
Fil: Wigdorovitz, Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina
Fil: Parreño, Viviana. Instituto Nacional de Tecnología Agropecuaria (INTA). Incuinta e Instituto de Virología; Argentina
description Objective: This study evaluated the effect of a novel subunit-targeted vaccine against BVDV in six dairy farms in Argentina. Methods: Reproductive, health, and production parameters—including conception and abortion rates, open days, calves born per insemination, as well as newborn and overall mortality, and milk production—were monitored over a ten-year period (2014–2023). Data were analyzed annually to assess trends and compare the periods before and after vaccine introduction. Results: All parameters showed significant improvement after vaccine incorporation, with an 11% increase in conception rate, a 5% reduction in abortion rate, a 12% increase in calves per insemination rate, and a decrease of 11 open days (8.4%). Additionally, newborn mortality and overall mortality decreased by 33% and 16%, respectively, while milk production increased by 9%. These data were also compared with eight non-vaccinated dairy farms, and significant differences were observed in health and reproductive parameters. Conclusions: These findings indicate that vaccination with an effective non-replicating subunit vaccine can successfully minimize the impact of BVDV in dairy farms.
publishDate 2025
dc.date.none.fl_str_mv 2025-03-19T11:46:57Z
2025-03-19T11:46:57Z
2025-03-17
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/21725
https://www.mdpi.com/2076-393X/13/3/319
2076-393X
https://doi.org/10.3390/vaccines13030319
url http://hdl.handle.net/20.500.12123/21725
https://www.mdpi.com/2076-393X/13/3/319
https://doi.org/10.3390/vaccines13030319
identifier_str_mv 2076-393X
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Vaccines 13 (3) : 319. (March 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.712165

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