Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case

Autores
Poli, Mario Andres; Caffaro, María Eugenia; Cetra, Bibiana Maria; Pichler, Rudolf; Raschia, Maria Agustina; Medus, Pablo Daniel; Maizon, Daniel Omar; Garcia Podesta, Mario; Donzelli, María Valeria; Bonelli, Rita; Periasamy, Kathiravan
Año de publicación
2023
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Gastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding and management practices aimed at an integrated control of parasites, such as raising parasiteresistant sheep, are required. This study focused on the genetic variation underlying parasite resistance in sheep, for potential use in breeding programmes. An artificial challenge with infectious H. contortus L3 was carried out in the northeast region of Argentina for more than 10 years in 1 072 Corriedale lambs with an average age of 5.6 months. Body weight, faecal egg count, packed cell volume, and FAMACHA© score were recorded at different time points post-challenge and their heritability and phenotypic and genetic correlations were estimated. Animals were genotyped on 173 single nucleotide polymorphisms belonging to 77 candidate genes for immune response. The results indicate that there is sufficient genetic variability for the four traits studied, which presented moderate heritabilities (in the range 0.29 to 0.44) and increased along the challenge period, with the exception of the hematocrit, which decreased. Association analyses identified seven markers associated with estimated breeding values for faecal egg count, located in genes involved in different stages of the pathogen-host interaction process. The information obtained supports the potential of markerassisted breeding schemes to enable profitable and sustainable sheep production.
Instituto de Genética
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; Argentina
Fil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Cetra, Bibiana Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Medus, Pablo Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; Argentina
Fil: Maizon, Daniel Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; Argentina
Fil: Garcia Podesta, Mario. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; Austria
Fil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Bonelli, Rita. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; Argentina
Fil: Periasamy, Kathiravan. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; Austria
Fuente
International Symposium on Sustainable Animal Production and Health : Current status and way forward, Viena, 28 June to 2 July 2021
Materia
Nematodes
Disease Resistance
Resilience
Candidate Genes
Sheep
Gastrointestinal Diseases
Parasites
Nematodos
Resistencia a la Enfermedad
Resiliencia
Genes Candidatos
Ovinos
Enfermedades Gastrointestinales
Parásitos
Argentina
Raza Corriedale
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean casePoli, Mario AndresCaffaro, María EugeniaCetra, Bibiana MariaPichler, RudolfRaschia, Maria AgustinaMedus, Pablo DanielMaizon, Daniel OmarGarcia Podesta, MarioDonzelli, María ValeriaBonelli, RitaPeriasamy, KathiravanNematodesDisease ResistanceResilienceCandidate GenesSheepGastrointestinal DiseasesParasitesNematodosResistencia a la EnfermedadResilienciaGenes CandidatosOvinosEnfermedades GastrointestinalesParásitosArgentinaRaza CorriedaleGastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding and management practices aimed at an integrated control of parasites, such as raising parasiteresistant sheep, are required. This study focused on the genetic variation underlying parasite resistance in sheep, for potential use in breeding programmes. An artificial challenge with infectious H. contortus L3 was carried out in the northeast region of Argentina for more than 10 years in 1 072 Corriedale lambs with an average age of 5.6 months. Body weight, faecal egg count, packed cell volume, and FAMACHA© score were recorded at different time points post-challenge and their heritability and phenotypic and genetic correlations were estimated. Animals were genotyped on 173 single nucleotide polymorphisms belonging to 77 candidate genes for immune response. The results indicate that there is sufficient genetic variability for the four traits studied, which presented moderate heritabilities (in the range 0.29 to 0.44) and increased along the challenge period, with the exception of the hematocrit, which decreased. Association analyses identified seven markers associated with estimated breeding values for faecal egg count, located in genes involved in different stages of the pathogen-host interaction process. The information obtained supports the potential of markerassisted breeding schemes to enable profitable and sustainable sheep production.Instituto de GenéticaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; ArgentinaFil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Cetra, Bibiana Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Medus, Pablo Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; ArgentinaFil: Maizon, Daniel Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; ArgentinaFil: Garcia Podesta, Mario. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; AustriaFil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Bonelli, Rita. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; ArgentinaFil: Periasamy, Kathiravan. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; AustriaFAO2023-12-05T10:26:57Z2023-12-05T10:26:57Z2023info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/20.500.12123/16120978-92-5-137052-0International Symposium on Sustainable Animal Production and Health : Current status and way forward, Viena, 28 June to 2 July 2021reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticasinfo:eu-repograntAgreement/INTA/2019-PE-E6-I114-001, Caracterización de la diversidad genética de plantas, animales y microorganismos mediante herramientas de genómica aplicadainfo:eu-repograntAgreement/INTA/2019-PE-E6-I145-001, Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:31:24Zoai:localhost:20.500.12123/16120instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:31:24.69INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
title Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
spellingShingle Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
Poli, Mario Andres
Nematodes
Disease Resistance
Resilience
Candidate Genes
Sheep
Gastrointestinal Diseases
Parasites
Nematodos
Resistencia a la Enfermedad
Resiliencia
Genes Candidatos
Ovinos
Enfermedades Gastrointestinales
Parásitos
Argentina
Raza Corriedale
title_short Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
title_full Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
title_fullStr Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
title_full_unstemmed Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
title_sort Integrating technologies for the sustainable control of gastrointestinal parasites in sheep : The Argentinean case
dc.creator.none.fl_str_mv Poli, Mario Andres
Caffaro, María Eugenia
Cetra, Bibiana Maria
Pichler, Rudolf
Raschia, Maria Agustina
Medus, Pablo Daniel
Maizon, Daniel Omar
Garcia Podesta, Mario
Donzelli, María Valeria
Bonelli, Rita
Periasamy, Kathiravan
author Poli, Mario Andres
author_facet Poli, Mario Andres
Caffaro, María Eugenia
Cetra, Bibiana Maria
Pichler, Rudolf
Raschia, Maria Agustina
Medus, Pablo Daniel
Maizon, Daniel Omar
Garcia Podesta, Mario
Donzelli, María Valeria
Bonelli, Rita
Periasamy, Kathiravan
author_role author
author2 Caffaro, María Eugenia
Cetra, Bibiana Maria
Pichler, Rudolf
Raschia, Maria Agustina
Medus, Pablo Daniel
Maizon, Daniel Omar
Garcia Podesta, Mario
Donzelli, María Valeria
Bonelli, Rita
Periasamy, Kathiravan
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nematodes
Disease Resistance
Resilience
Candidate Genes
Sheep
Gastrointestinal Diseases
Parasites
Nematodos
Resistencia a la Enfermedad
Resiliencia
Genes Candidatos
Ovinos
Enfermedades Gastrointestinales
Parásitos
Argentina
Raza Corriedale
topic Nematodes
Disease Resistance
Resilience
Candidate Genes
Sheep
Gastrointestinal Diseases
Parasites
Nematodos
Resistencia a la Enfermedad
Resiliencia
Genes Candidatos
Ovinos
Enfermedades Gastrointestinales
Parásitos
Argentina
Raza Corriedale
dc.description.none.fl_txt_mv Gastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding and management practices aimed at an integrated control of parasites, such as raising parasiteresistant sheep, are required. This study focused on the genetic variation underlying parasite resistance in sheep, for potential use in breeding programmes. An artificial challenge with infectious H. contortus L3 was carried out in the northeast region of Argentina for more than 10 years in 1 072 Corriedale lambs with an average age of 5.6 months. Body weight, faecal egg count, packed cell volume, and FAMACHA© score were recorded at different time points post-challenge and their heritability and phenotypic and genetic correlations were estimated. Animals were genotyped on 173 single nucleotide polymorphisms belonging to 77 candidate genes for immune response. The results indicate that there is sufficient genetic variability for the four traits studied, which presented moderate heritabilities (in the range 0.29 to 0.44) and increased along the challenge period, with the exception of the hematocrit, which decreased. Association analyses identified seven markers associated with estimated breeding values for faecal egg count, located in genes involved in different stages of the pathogen-host interaction process. The information obtained supports the potential of markerassisted breeding schemes to enable profitable and sustainable sheep production.
Instituto de Genética
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; Argentina
Fil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Cetra, Bibiana Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Medus, Pablo Daniel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; Argentina
Fil: Maizon, Daniel Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; Argentina
Fil: Garcia Podesta, Mario. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; Austria
Fil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Bonelli, Rita. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Concepción del Uruguay; Argentina
Fil: Periasamy, Kathiravan. Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency. Animal Production and Health Laboratory; Austria
description Gastrointestinal nematode infections in sheep are a major concern among breeders due to the economic losses they cause in terms of a reduction in both productivity and viability of animals. The situation worsens in face of the emergence of anthelmintic-resistant parasites. In this context, breeding and management practices aimed at an integrated control of parasites, such as raising parasiteresistant sheep, are required. This study focused on the genetic variation underlying parasite resistance in sheep, for potential use in breeding programmes. An artificial challenge with infectious H. contortus L3 was carried out in the northeast region of Argentina for more than 10 years in 1 072 Corriedale lambs with an average age of 5.6 months. Body weight, faecal egg count, packed cell volume, and FAMACHA© score were recorded at different time points post-challenge and their heritability and phenotypic and genetic correlations were estimated. Animals were genotyped on 173 single nucleotide polymorphisms belonging to 77 candidate genes for immune response. The results indicate that there is sufficient genetic variability for the four traits studied, which presented moderate heritabilities (in the range 0.29 to 0.44) and increased along the challenge period, with the exception of the hematocrit, which decreased. Association analyses identified seven markers associated with estimated breeding values for faecal egg count, located in genes involved in different stages of the pathogen-host interaction process. The information obtained supports the potential of markerassisted breeding schemes to enable profitable and sustainable sheep production.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-05T10:26:57Z
2023-12-05T10:26:57Z
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/16120
978-92-5-137052-0
url http://hdl.handle.net/20.500.12123/16120
identifier_str_mv 978-92-5-137052-0
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas
info:eu-repograntAgreement/INTA/2019-PE-E6-I114-001, Caracterización de la diversidad genética de plantas, animales y microorganismos mediante herramientas de genómica aplicada
info:eu-repograntAgreement/INTA/2019-PE-E6-I145-001, Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animal
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv FAO
publisher.none.fl_str_mv FAO
dc.source.none.fl_str_mv International Symposium on Sustainable Animal Production and Health : Current status and way forward, Viena, 28 June to 2 July 2021
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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