Genetic resistance to gastrointestinal parasites in sheep

Autores
Poli, Mario Andres; Donzelli, María Valeria; Caffaro, María Eugenia; Raschia, Maria Agustina; Papaleo Mazzucco, Juliana; Rossi, Ursula Amaranta
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, and indiscriminate use of these drugs has led to the emergence and spread of strains of parasites resistant to the major chemical compounds used. This situation has led to considering alternative strategies for worm control. One of them is the selection of individuals for greater resistance to GINs. A number of phenotypic traits have been reported in the bibliography, including parasitological, biochemical, hematological, and immunological traits, but fecal egg count (FEC) is considered the primary and most practical measure of resistance. Genomic studies have reported polymorphisms associated with GIN resistance traits on almost all sheep chromosomes. Among other loci, FEC has been associated with the major histocompatibility complex (MHC) through quantitative trait loci (QTL) analysis and genome-wide association studies (GWAS). This review covers the principal aspects reported in the literature on several parameters considered to evaluate the resistance status of sheep to nematodes, mainly Haemonchus contortus, the correlation between resistance markers with economically important production traits, and the main genomic regions identified as relevant in determining the phenotype for resistance or susceptibility to GINs.
Instituto de Genética
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; Argentina
Fil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Donzelli, María Valeria. Universidad Nacional de Lomas de Zamora. Facultad de Ciencias Agrarias; Argentina
Fil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Raschia, Maria Agustina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fuente
CABI Reviews 18 : 1 (Junio 2023)
Materia
Nematodes
Resistencia Genética
Genes Candidatos
Sistema mhc
Respuesta Inmunológica
Ovinos
Enfermedades Gastrointestinales
Genetic Resistance
Candidate Genes
Major Histocompatibility Complex
Immune Response
Sheep
Gastrointestinal Diseases
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/15198
Acceder
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oai_identifier_str oai:localhost:20.500.12123/15198
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network_name_str INTA Digital (INTA)
spelling Genetic resistance to gastrointestinal parasites in sheepPoli, Mario AndresDonzelli, María ValeriaCaffaro, María EugeniaRaschia, Maria AgustinaPapaleo Mazzucco, JulianaRossi, Ursula AmarantaNematodesResistencia GenéticaGenes CandidatosSistema mhcRespuesta InmunológicaOvinosEnfermedades GastrointestinalesGenetic ResistanceCandidate GenesMajor Histocompatibility ComplexImmune ResponseSheepGastrointestinal DiseasesGastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, and indiscriminate use of these drugs has led to the emergence and spread of strains of parasites resistant to the major chemical compounds used. This situation has led to considering alternative strategies for worm control. One of them is the selection of individuals for greater resistance to GINs. A number of phenotypic traits have been reported in the bibliography, including parasitological, biochemical, hematological, and immunological traits, but fecal egg count (FEC) is considered the primary and most practical measure of resistance. Genomic studies have reported polymorphisms associated with GIN resistance traits on almost all sheep chromosomes. Among other loci, FEC has been associated with the major histocompatibility complex (MHC) through quantitative trait loci (QTL) analysis and genome-wide association studies (GWAS). This review covers the principal aspects reported in the literature on several parameters considered to evaluate the resistance status of sheep to nematodes, mainly Haemonchus contortus, the correlation between resistance markers with economically important production traits, and the main genomic regions identified as relevant in determining the phenotype for resistance or susceptibility to GINs.Instituto de GenéticaFil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; ArgentinaFil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Donzelli, María Valeria. Universidad Nacional de Lomas de Zamora. Facultad de Ciencias Agrarias; ArgentinaFil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; ArgentinaFil: Raschia, Maria Agustina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaCAB International2023-09-13T13:02:56Z2023-09-13T13:02:56Z2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/15198https://www.cabidigitallibrary.org/doi/10.1079/cabireviews.2023.00191749-8848https://doi.org/10.1079/cabireviews.2023.0019CABI Reviews 18 : 1 (Junio 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticasinfo:eu-repograntAgreement/INTA/2019-PE-E6-I114-001, Caracterización de la diversidad genética de plantas, animales y microorganismos mediante herramientas de genómica aplicada.info:eu-repograntAgreement/INTA/2019-PE-E6-I145-001, Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animal.info:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:31:16Zoai:localhost:20.500.12123/15198instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:31:17.187INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Genetic resistance to gastrointestinal parasites in sheep
title Genetic resistance to gastrointestinal parasites in sheep
spellingShingle Genetic resistance to gastrointestinal parasites in sheep
Poli, Mario Andres
Nematodes
Resistencia Genética
Genes Candidatos
Sistema mhc
Respuesta Inmunológica
Ovinos
Enfermedades Gastrointestinales
Genetic Resistance
Candidate Genes
Major Histocompatibility Complex
Immune Response
Sheep
Gastrointestinal Diseases
title_short Genetic resistance to gastrointestinal parasites in sheep
title_full Genetic resistance to gastrointestinal parasites in sheep
title_fullStr Genetic resistance to gastrointestinal parasites in sheep
title_full_unstemmed Genetic resistance to gastrointestinal parasites in sheep
title_sort Genetic resistance to gastrointestinal parasites in sheep
dc.creator.none.fl_str_mv Poli, Mario Andres
Donzelli, María Valeria
Caffaro, María Eugenia
Raschia, Maria Agustina
Papaleo Mazzucco, Juliana
Rossi, Ursula Amaranta
author Poli, Mario Andres
author_facet Poli, Mario Andres
Donzelli, María Valeria
Caffaro, María Eugenia
Raschia, Maria Agustina
Papaleo Mazzucco, Juliana
Rossi, Ursula Amaranta
author_role author
author2 Donzelli, María Valeria
Caffaro, María Eugenia
Raschia, Maria Agustina
Papaleo Mazzucco, Juliana
Rossi, Ursula Amaranta
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nematodes
Resistencia Genética
Genes Candidatos
Sistema mhc
Respuesta Inmunológica
Ovinos
Enfermedades Gastrointestinales
Genetic Resistance
Candidate Genes
Major Histocompatibility Complex
Immune Response
Sheep
Gastrointestinal Diseases
topic Nematodes
Resistencia Genética
Genes Candidatos
Sistema mhc
Respuesta Inmunológica
Ovinos
Enfermedades Gastrointestinales
Genetic Resistance
Candidate Genes
Major Histocompatibility Complex
Immune Response
Sheep
Gastrointestinal Diseases
dc.description.none.fl_txt_mv Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, and indiscriminate use of these drugs has led to the emergence and spread of strains of parasites resistant to the major chemical compounds used. This situation has led to considering alternative strategies for worm control. One of them is the selection of individuals for greater resistance to GINs. A number of phenotypic traits have been reported in the bibliography, including parasitological, biochemical, hematological, and immunological traits, but fecal egg count (FEC) is considered the primary and most practical measure of resistance. Genomic studies have reported polymorphisms associated with GIN resistance traits on almost all sheep chromosomes. Among other loci, FEC has been associated with the major histocompatibility complex (MHC) through quantitative trait loci (QTL) analysis and genome-wide association studies (GWAS). This review covers the principal aspects reported in the literature on several parameters considered to evaluate the resistance status of sheep to nematodes, mainly Haemonchus contortus, the correlation between resistance markers with economically important production traits, and the main genomic regions identified as relevant in determining the phenotype for resistance or susceptibility to GINs.
Instituto de Genética
Fil: Poli, Mario Andres. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Poli, Mario Andres. Universidad del Salvador. Facultad de Ciencias Agrarias y Veterinaria; Argentina
Fil: Donzelli, María Valeria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Donzelli, María Valeria. Universidad Nacional de Lomas de Zamora. Facultad de Ciencias Agrarias; Argentina
Fil: Caffaro, Marí­a Eugenia. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Raschia, Maria Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Genética; Argentina
Fil: Raschia, Maria Agustina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Rossi, Ursula Amaranta. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
description Gastrointestinal nematode (GIN) infection is the most common disease affecting sheep production systems throughout the world, causing significant productive and economic losses. The control of these parasites was traditionally based on the use of anthelmintic drugs. However, continuous, extensive, and indiscriminate use of these drugs has led to the emergence and spread of strains of parasites resistant to the major chemical compounds used. This situation has led to considering alternative strategies for worm control. One of them is the selection of individuals for greater resistance to GINs. A number of phenotypic traits have been reported in the bibliography, including parasitological, biochemical, hematological, and immunological traits, but fecal egg count (FEC) is considered the primary and most practical measure of resistance. Genomic studies have reported polymorphisms associated with GIN resistance traits on almost all sheep chromosomes. Among other loci, FEC has been associated with the major histocompatibility complex (MHC) through quantitative trait loci (QTL) analysis and genome-wide association studies (GWAS). This review covers the principal aspects reported in the literature on several parameters considered to evaluate the resistance status of sheep to nematodes, mainly Haemonchus contortus, the correlation between resistance markers with economically important production traits, and the main genomic regions identified as relevant in determining the phenotype for resistance or susceptibility to GINs.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-13T13:02:56Z
2023-09-13T13:02:56Z
2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/15198
https://www.cabidigitallibrary.org/doi/10.1079/cabireviews.2023.0019
1749-8848
https://doi.org/10.1079/cabireviews.2023.0019
url http://hdl.handle.net/20.500.12123/15198
https://www.cabidigitallibrary.org/doi/10.1079/cabireviews.2023.0019
https://doi.org/10.1079/cabireviews.2023.0019
identifier_str_mv 1749-8848
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001, Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas
info:eu-repograntAgreement/INTA/2019-PE-E6-I114-001, Caracterización de la diversidad genética de plantas, animales y microorganismos mediante herramientas de genómica aplicada.
info:eu-repograntAgreement/INTA/2019-PE-E6-I145-001, Mejora genética objetiva para aumentar la eficiencia de los sistemas de producción animal.
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CAB International
publisher.none.fl_str_mv CAB International
dc.source.none.fl_str_mv CABI Reviews 18 : 1 (Junio 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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